Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Kenneth C. Keiler"'
Autor:
Neeraja Marathe, Ha An Nguyen, John N. Alumasa, Alexandra B. Kuzmishin Nagy, Michael Vazquez, Christine M. Dunham, Kenneth C. Keiler
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT trans-Translation is conserved throughout bacteria and is essential in many species. High-throughput screening identified a tetrazole-based trans-translation inhibitor, KKL-55, that has broad-spectrum antibiotic activity. A biotinylated vers
Externí odkaz:
https://doaj.org/article/3798d2a02c844a40a0b3917376c78437
Autor:
Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are e
Externí odkaz:
https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e630
Autor:
Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth C. Keiler, Anthony D. Baughn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism of action remains unresolved. Recently, it was proposed that the active form of PZA, pyrazinoic acid (POA), disrupts the ribosome rescue process of trans-transla
Externí odkaz:
https://doaj.org/article/4da58e057f364be4a086d7bff82b17a5
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Bacterial ribosomes frequently translate to the 3′ end of an mRNA without terminating at an in-frame stop codon. In all bacteria studied to date, these “nonstop” ribosomes are rescued using trans-translation. Genes required for trans-t
Externí odkaz:
https://doaj.org/article/60f46cf7423c4dac9874bbae57cd928f
Autor:
John N. Alumasa, Kenneth C. Keiler
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Externí odkaz:
https://doaj.org/article/8492dbd696334bd68a2a9867010f84e8
Publikováno v:
mBio, Vol 5, Iss 6 (2014)
ABSTRACT Bacterial ribosomes frequently translate to the 3′ end of an mRNA without terminating at a stop codon. Almost all bacteria use the transfer-messenger RNA (tmRNA)-based trans-translation pathway to release these “nonstop” ribosomes and
Externí odkaz:
https://doaj.org/article/fe1580f287ca4df3820ac24585f70590
Publikováno v:
Bioessays
Bacteria use trans-translation to rescue stalled ribosomes and target incomplete proteins for proteolysis. Despite similarities between tRNAs and transfer-messenger RNA (tmRNA), the key molecule for trans-translation, new structural and biochemical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a715a5c46d827bcdd8602200c388fecc
https://europepmc.org/articles/PMC9308750/
https://europepmc.org/articles/PMC9308750/
Autor:
Stephanie L. Leedom, Kenneth C. Keiler
Publikováno v:
Nature
Curr Biol
Curr Biol
Ribosome stalling during translation is detrimental to cellular fitness, but how this is sensed and elicits recycling of ribosomal subunits and quality control of associated mRNA and incomplete nascent-chains is poorly understood(1,2). Here we uncove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fe7ec9000eeda95dddd21ecaa95633
https://pubmed.ncbi.nlm.nih.gov/35264791
https://pubmed.ncbi.nlm.nih.gov/35264791
Autor:
Andrew W. Simonson, Kenneth C. Keiler, Scott H. Medina, Atip Lawanprasert, Tyler D. P. Goralski
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 17:391-400
We report the design, synthesis and efficacy of a new class of gel-like nano-carrier, or 'nanogel', prepared via templated electrostatic assembly of anionic hyaluronic acid (HA) polysaccharides with the cationic peptide amphiphile poly-L-lysine (PLL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbf91f768b6fa90018482c31f7dd529
https://doi.org/10.1016/j.nano.2018.10.008
https://doi.org/10.1016/j.nano.2018.10.008
Autor:
Atousa Mehrani, Mynthia Cabrera, Kenneth C. Keiler, Michelle M. Butler, Steven M. Kwasny, Pooja Srinivas, Lucas R. Morin, Divya Hosangadi, John N. Alumasa, Jay S. Barbor, Steven C. Cardinale, Scott M. Stagg, Zachary D. Aron, Christine M. Dunham, Ann E. Jerse, Matthew C. Torhan, Timothy J. Opperman, Eric D. Hoffer, Terry L. Bowlin, Kristie L. Connolly
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411f83145a0e100fbdf1e585bbf3dfa6
https://doi.org/10.1038/s41467-021-22012-7
https://doi.org/10.1038/s41467-021-22012-7