Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Kenneth C. Keiler"'
Autor:
Neeraja Marathe, Ha An Nguyen, John N. Alumasa, Alexandra B. Kuzmishin Nagy, Michael Vazquez, Christine M. Dunham, Kenneth C. Keiler
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT trans-Translation is conserved throughout bacteria and is essential in many species. High-throughput screening identified a tetrazole-based trans-translation inhibitor, KKL-55, that has broad-spectrum antibiotic activity. A biotinylated vers
Externí odkaz:
https://doaj.org/article/3798d2a02c844a40a0b3917376c78437
Autor:
Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, Kristie L. Connolly, Pooja Srinivas, Matthew C. Torhan, John N. Alumasa, Mynthia Cabrera, Divya Hosangadi, Jay S. Barbor, Steven C. Cardinale, Steven M. Kwasny, Lucas R. Morin, Michelle M. Butler, Timothy J. Opperman, Terry L. Bowlin, Ann Jerse, Scott M. Stagg, Christine M. Dunham, Kenneth C. Keiler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Antibiotic-resistant bacterial pathogens pose a substantial threat to human health. Here, aided by structural analyses, the authors describe the molecular mechanism behind the activity of a series of compounds that inhibit trans-translation and are e
Externí odkaz:
https://doaj.org/article/65f0e506e42e4cd09c551a4db2d7e630
Autor:
Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth C. Keiler, Anthony D. Baughn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism of action remains unresolved. Recently, it was proposed that the active form of PZA, pyrazinoic acid (POA), disrupts the ribosome rescue process of trans-transla
Externí odkaz:
https://doaj.org/article/4da58e057f364be4a086d7bff82b17a5
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Bacterial ribosomes frequently translate to the 3′ end of an mRNA without terminating at an in-frame stop codon. In all bacteria studied to date, these “nonstop” ribosomes are rescued using trans-translation. Genes required for trans-t
Externí odkaz:
https://doaj.org/article/60f46cf7423c4dac9874bbae57cd928f
Publikováno v:
PLoS Biology, Vol 15, Iss 3, p e2001318 (2017)
Science plays an important role in most aspects of society, and scientists face ethical decisions as a routine part of their work, but science education frequently omits or segregates content related to ethics and broader impacts of science. Undergra
Externí odkaz:
https://doaj.org/article/eb75d5eabcd34781ae10621cc39f30f2
Publikováno v:
Bioessays
Bacteria use trans-translation to rescue stalled ribosomes and target incomplete proteins for proteolysis. Despite similarities between tRNAs and transfer-messenger RNA (tmRNA), the key molecule for trans-translation, new structural and biochemical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a715a5c46d827bcdd8602200c388fecc
https://europepmc.org/articles/PMC9308750/
https://europepmc.org/articles/PMC9308750/
Autor:
Stephanie L. Leedom, Kenneth C. Keiler
Publikováno v:
Nature
Curr Biol
Curr Biol
Ribosome stalling during translation is detrimental to cellular fitness, but how this is sensed and elicits recycling of ribosomal subunits and quality control of associated mRNA and incomplete nascent-chains is poorly understood(1,2). Here we uncove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fe7ec9000eeda95dddd21ecaa95633
https://pubmed.ncbi.nlm.nih.gov/35264791
https://pubmed.ncbi.nlm.nih.gov/35264791
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005964 (2016)
Bacteria use trans-translation and the alternative rescue factors ArfA (P36675) and ArfB (Q9A8Y3) to hydrolyze peptidyl-tRNA on ribosomes that stall near the 3' end of an mRNA during protein synthesis. The eukaryotic protein ICT1 (Q14197) is homologo
Externí odkaz:
https://doaj.org/article/443dbf7924674974a870c5d3df674158
Autor:
John N. Alumasa, Kenneth C. Keiler
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Externí odkaz:
https://doaj.org/article/8492dbd696334bd68a2a9867010f84e8
Publikováno v:
mBio, Vol 5, Iss 6 (2014)
ABSTRACT Bacterial ribosomes frequently translate to the 3′ end of an mRNA without terminating at a stop codon. Almost all bacteria use the transfer-messenger RNA (tmRNA)-based trans-translation pathway to release these “nonstop” ribosomes and
Externí odkaz:
https://doaj.org/article/fe1580f287ca4df3820ac24585f70590