Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kenneth C. Bonanno"'
Autor:
William P. Taylor, Mark Edward Bunnage, Hardwin O'dowd, Michael P. Clark, Dan Crawford, Sanjay Shivayogi Magavi, Bin Song, Jianglin Liang, Timothy J. Senter, Tal Kramer, Juntyma J. Engtrakul, Arun K. Mohanty, Fan Lu, Hong Gao, Yulin Huang, Swett Rebecca Jane, Bryan W. Vought, Ray Winquist, Tony Considine, Ganesh Iyer, Kenneth C. Bonanno, Elisabeth Doyle, Suganthini Nanthakumar, Raymond Kemper, Elaine Krueger, Cameron Stuver Moody, Joyce T. Coll, Paul S. Charifson, John J. Court, Wenxin Gu, Francois Maltais, Gale-Day Zachary, Ananthisrinivas Chakilam, Jon H. Come, John L. Andreassi, Morris Mark A, Brinley Furey, Christina Boucher, Martin Sanders, Harmon J. Zuccola, Gagnon Kevin James, Katrina L. Jackson, Lu Gan, Jonathan A. Phillips
Publikováno v:
Journal of Medicinal Chemistry. 64:17753-17776
Accumulation of very long chain fatty acids (VLCFAs) due to defects in ATP binding cassette protein D1 (ABCD1) is thought to underlie the pathologies observed in adrenoleukodystrophy (ALD). Pursuing a substrate reduction approach based on the inhibit
Autor:
Joshua R. Leeman, Joyce T. Coll, Upul K. Bandarage, Derek B. Lowe, Alex Aronov, Christine Memmott, Jacque Zwahlen, Kenneth C. Bonanno, Emanuele Perola, William P. Taylor, Christopher A. Lepre, Dean M. Wilson, Yi Zhou, Rene Rijnbrand, Dominique Bonafoux, Fan Lu, Bhisetti Govinda Rao, Ernst ter Haar, Suganthini Nanthakumar
Publikováno v:
Journal of Medicinal Chemistry. 59:7138-7151
There are currently no treatments for life-threatening infections caused by human polyomaviruses JCV and BKV. We therefore report herein the first crystal structure of the hexameric helicase of JCV large T antigen (apo) and its use to drive the struc