Zobrazeno 1 - 10 of 145 pro vyhledávání: '"Kenneth C McCullough"'
1
Akademický článek
Sensing of porcine reproductive and respiratory syndrome virus-infected macrophages by plasmacytoid dendritic cells
Autor: Obdulio eGarcía-Nicolás, Gaël eAuray, Carmen Alexandra Sautter, Julie eRappe, Kenneth C McCullough, Nicolas eRuggli, Artur eSummerfield
Publikováno v: Frontiers in Microbiology, Vol 7 (2016)
Porcine reproductive and respiratory syndrome virus (PRRSV) represents a macrophage (MØ)-tropic virus which is unable to induce interferon (IFN) type I in its target cells. Nevertheless, infected pigs show a short but prominent systemic IFN alpha (I
Externí odkaz: https://doaj.org/article/db605805df1a40b5bcc286508e3b2707
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2
Akademický článek
Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo
Autor: Kenneth C McCullough, Isabelle Bassi, Panagiota Milona, Rolf Suter, Lisa Thomann-Harwood, Pavlos Englezou, Thomas Démoulins, Nicolas Ruggli
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Self-amplifying replicon RNA (RepRNA) possesses high potential for increasing antigen load within dendritic cells (DCs). The major aim of the present work was to define how RepRNA delivered by biodegradable, chitosan-based nanoparticulate delivery ve
Externí odkaz: https://doaj.org/article/5a224979cb0c41f395b0bcaf8cec7b56
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3
Akademický článek
Synthetic virus-like particles target dendritic cell lipid rafts for rapid endocytosis primarily but not exclusively by macropinocytosis.
Autor: Rajni Sharma, Arin Ghasparian, John A Robinson, Kenneth C McCullough
Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43248 (2012)
DC employ several endocytic routes for processing antigens, driving forward adaptive immunity. Recent advances in synthetic biology have created small (20-30 nm) virus-like particles based on lipopeptides containing a virus-derived coiled coil sequen
Externí odkaz: https://doaj.org/article/0bcf0f7b35514432b4102224627a6079
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4
Akademický článek
Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs
Autor: Thomas Démoulins, Nicolas Ruggli, Markus Gerber, Lisa J. Thomann-Harwood, Thomas Ebensen, Kai Schulze, Carlos A. Guzmán, Kenneth C. McCullough
Publikováno v: Frontiers in Immunology, Vol 11 (2021)
Self-amplifying replicon RNA (RepRNA) promotes expansion of mRNA templates encoding genes of interest through their replicative nature, thus providing increased antigen payloads. RepRNA derived from the non-cytopathogenic classical swine fever virus
Externí odkaz: https://doaj.org/article/72c33a18d5aa4e0e9c09ca14e4a06c82
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5
Glycan-binding profile of DC-like cells
Autor: Sergey V. Khaidukov, Svetlana V. Tsygankova, Eugenia M. Rapoport, Nicolai V. Bovin, Kenneth C. McCullough, E.V. Moiseeva, Galina V. Pazynina, Ivan M. Belyanchikov, Tatiana V. Tyrtysh, Ivan M. Ryzhov, D.A. Aronov
Publikováno v: Glycoconjugate Journal. 37:129-138
Modification of vaccine carriers by decoration with glycans can enhance binding to and even targeting of dendritic cells (DCs), thus augmenting vaccine efficacy. To find a specific glycan-“vector” it is necessary to know glycan-binding profile of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257f6e9caad68c6996245c673bacd662
https://doi.org/10.1007/s10719-019-09897-9
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6
Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs
Autor: Thomas Démoulins, Nicolas Ruggli, Markus Gerber, Lisa J. Thomann-Harwood, Thomas Ebensen, Kai Schulze, Carlos A. Guzmán, Kenneth C. McCullough
Publikováno v: Frontiers in immunology
Switzerland
Frontiers in Immunology, Vol 11 (2021)
Frontiers in Immunology
Démoulins, Thomas; Ruggli, Nicolas; Gerber, Markus; Thomann-Harwood, Lisa J; Ebensen, Thomas; Schulze, Kai; Guzmán, Carlos A; McCullough, Kenneth C (2021). Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs. Frontiers in immunology, 11, p. 622385. Frontiers Research Foundation 10.3389/fimmu.2020.622385
Self-amplifying replicon RNA (RepRNA) promotes expansion of mRNA templates encoding genes of interest through their replicative nature, thus providing increased antigen payloads. RepRNA derived from the non-cytopathogenic classical swine fever virus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba0afa7741b5ce14e7753219293b9fc
https://pubmed.ncbi.nlm.nih.gov/33584723
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7
Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure
Autor: Kenneth C. McCullough, Nicolas Ruggli, Thomas Ebensen, Carlos Guzmán, Maria Pelliccia, Pavlos C. Englezou, Kai Schulze, Thomas Démoulins
Publikováno v: Journal of Controlled Release. 266:256-271
The major limitations with large and complex self-amplifying RNA vaccines (RepRNA) are RNase-sensitivity and inefficient translation in dendritic cells (DCs). Condensing RepRNA with polyethylenimine (PEI) gave positive in vitro readouts, but was larg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b6f58ef30851001f0e1a773e635ea7
https://doi.org/10.1016/j.jconrel.2017.09.018
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8
Dendritic Cell Sensing of Hydrophobic Di- and Triacylated Lipopeptides Self-Assembled within Synthetic Virus-like Particles
Autor: Arin Ghasparian, Kenneth C. McCullough, Rajni Sharma, John A. Robinson
Publikováno v: The Journal of Immunology. 199:734-749
Dendritic cells (DCs) play critical roles in developing immune defenses. One important aspect is interaction with pathogen-associated molecular patterns (PAMPs)/danger-associated molecular patterns, including di- and triacylated lipopeptides. Isolate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a49a26f60954064e3e708c6b6b5ab04
https://doi.org/10.4049/jimmunol.1600521
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10
Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids
Autor: Panagiota Milona, Florent Poulhes, Pavlos C. Englezou, Kai Schulze, Olivier Zelphati, Thomas Démoulins, Thomas Ebensen, Cédric Sapet, Kenneth C. McCullough, Nicolas Ruggli, Carlos-Alberto Guzman
Publikováno v: Molecular Therapy-Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 12, Iss, Pp 118-134 (2018)
Molecular Therapy. Nucleic Acids
Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications. Cytosolic delivery is essential for the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a80cf18a8e180baaebc12d8f47a81a0
https://hdl.handle.net/10033/621415
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