Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kenneth C, Cassidy"'
Autor:
Graeme C. Young, Douglas K. Spracklin, Alexander D. James, Mette G. Hvenegaard, Graeme Scarfe, David S. Wagner, Katrin Georgi, Hanno Schieferstein, Inga Bjornsdottir, Bianca van Groen, Andrea A. Romeo, Kenneth C. Cassidy, Georges Da‐violante, Bojan Bister, Stefan Blech, Ramaswamy Lyer, Simone I. Schulz, Filip Cuyckens, Patricia Moliner
Publikováno v:
Clinical pharmacology and therapeutics.
The human absorption, distribution, metabolism, and excretion (hADME) study is the cornerstone of the clinical pharmacology package for small molecule drugs, providing comprehensive information on the rates and routes of disposition and elimination o
Publikováno v:
Drug Metabolism and Disposition. 48:698-707
The mass balance, excretion, and metabolism of LY3202626 were determined in healthy subjects after oral administration of a single dose of 10 mg of (approximately 100 μCi) [14C]LY3202626. Excretion of radioactivity was slow and incomplete, with appr
Autor:
Kenneth C. Cassidy, Christopher D. Payne, Scott M. Hynes, Enaksha R Wickremsinhe, Yingying Guo
Publikováno v:
Xenobiotica. 50:793-804
The disposition and metabolism of prexasertib, a CHK-1 inhibitor was characterised over a 120 h period following a single 170-mg intravenous dose of [14C]prexasertib (50 µCi) to 6 patients with adv...
Autor:
Jeff Alberts, Jennifer Martin, Kenneth C. Cassidy, Yanbin Lao, Jennifer Gluff, Andrea M. Niedenthal, Boris A. Czeskis
Publikováno v:
Diabetes. 69
Novel dual GIP and GLP-1 receptor agonist, tirzepatide (TZP), is being developed as a potential weekly treatment for type 2 diabetes (T2DM), weight management and nonalcoholic steatohepatitis. The absorption, metabolism and excretion of a single subc
Autor:
Enaksha R, Wickremsinhe, Scott M, Hynes, Christopher D, Payne, Yingying, Guo, Kenneth C, Cassidy
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 50(7)
The disposition and metabolism of prexasertib, a CHK-1 inhibitor was characterised over a 120 h period following a single 170-mg intravenous dose of [
Autor:
Boris A. Czeskis, Bryan H. Norman, Norman Earle Hughes, Kenneth C. Cassidy, Kuklish Steven Lee, Debra Luffer-Atlas, Matthew Fisher, Trent L. Abraham, Matthew Allen Schiffler, Jeffrey J. Alberts
Publikováno v:
Journal of Medicinal Chemistry. 61:2041-2051
Two 2-aminoimidazole-based inhibitors, LY3031207 (1) and LY3023703 (2), of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme were found to cause drug-induced liver injury (DILI) in humans. We studied imidazole ring substitutions to successfu
Autor:
Michael A. Mohutsky, Junliang Hao, Xin Zhou, Kenneth C. Cassidy, Loyd R. Hudson, Geri A. Sawada
Publikováno v:
Pharmacology Research & Perspectives
The enterohepatic circulation (EHC) of drugs is often the result of the direct glucuronidation, excretion of the metabolite into bile, followed by hydrolysis to the aglycone by the gut microbiome and finally reabsorption of drug into the systemic cir
Autor:
David W. Bedwell, Luc Rougée, Jeff W Cramer, Nathan A Calvert, Nathan Yumibe, Kenneth J. Ruterbories, Kenneth C. Cassidy, Richard Moulton, Michael A. Mohutsky, Lisa A. Adams, Xin Zhou
Publikováno v:
Drug Metabolism and Disposition. 44:1184-1192
The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic changes resemble human type 2 diabetes associated with obesity a
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S39
Autor:
Kenneth C, Cassidy, Ivelina, Gueorguieva, Colin, Miles, Jessica, Rehmel, Ping, Yi, William J, Ehlhardt
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(4)
1. The disposition and metabolism of galunisertib (LY2157299 monohydrate, a TGF-βRI Kinase/ALK5 Inhibitor) was characterized following a single oral dose of 150 mg of [