Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kenneth Burnside Ramsay Ewan"'
Autor:
Ana Jimenez-Pascual, Iestyn Pope, Florian A. Siebzehnrubl, Kenneth Burnside Ramsay Ewan, Wolfgang Werner Langbein, Paola Borri, Trevor Clive Dale, Francesco Masia
Publikováno v:
The Analyst
Quantitative hyperspectral coherent Raman scattering microscopy merges imaging with spectroscopy and utilises quantitative data analysis algorithms to extract physically meaningful chemical components, spectrally and spatially-resolved, with sub-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f14b420776ef6c2a40b93f4075761b2
https://doi.org/10.1039/d0an02381g
https://doi.org/10.1039/d0an02381g
Autor:
Kuan Yan, Bahar Ramezanpour, Leo S. Price, Christina Esdar, Mairian Thomas, Hans-Peter Buchstaller, Marc Naven, Trevor Clive Dale, Jennifer R. Shone, Paul Shaw, Kenneth Burnside Ramsay Ewan, Luned Badder, J. Mark Treherne, Delyth A. Badder, Sylvia F. Boj, Kevin E. Ashelford, Rachel Hargest, Bram Herpers, Andrew John Hollins, Dirk Wienke, Alan Richard Clarke
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235319 (2020)
PLoS ONE
PLoS ONE
Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of inhibitors of Wnt signalling has been the focus of multiple drug discovery programs targeting c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf18a324f5b253e614df4ccc90f0b7b
https://orca.cardiff.ac.uk/id/eprint/135946/1/journal.pone.0235319.pdf
https://orca.cardiff.ac.uk/id/eprint/135946/1/journal.pone.0235319.pdf
Autor:
Josephine Bradley, John L. Harwood, Arnica Karuna, Iestyn Pope, Paola Borri, Lukas M. Payne, Wolfgang Werner Langbein, Peter Duncan Watson, Francesco Masia, Kenneth Burnside Ramsay Ewan, Irina A. Guschina, Trevor Clive Dale, Karl Swann
Publikováno v:
ICTON
Optical microscopy is an indispensable tool that is driving progress in cell biology, and is still the only practical means of obtaining spatial and temporal resolution within living cells and tissues. Coherent Raman Scattering (CRS) microscopy has e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcf9ab5a21d243cd9b260ae3ee8157e
Autor:
Alexis De Haven Brandon, Paul Workman, Aurélie Mallinger, Elizabeth Fraser, Mark Stubbs, Paul Czodrowski, Andree Blaukat, Richard Schneider, Julian Blagg, Djordje Musil, Melanie Valenti, Daniel Schwarz, Rahul S. Samant, Klaus Schneider, Kai Schiemann, Sharon Gowan, Christina Esdar, Florence I. Raynaud, Suzanne A. Eccles, Robert TePoele, Dennis Waalboer, Gary Box, Dirk Wienke, Oliver Poeschke, Paul A. Clarke, Maria-Jesus Ortiz-Ruiz, Kenneth Burnside Ramsay Ewan, Trevor Clive Dale, Felix Rohdich, Olajumoke Adeniji-Popoola, Will Court
Publikováno v:
Nature chemical biology
There is unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545, a small-molecule inhibitor of the WNT pathway discovered through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5843c8e5265bc355469118273fb45d0b
https://doi.org/10.1038/nchembio.1952
https://doi.org/10.1038/nchembio.1952
Autor:
Laura Dietrich, Tom N. Grossmann, Bernd Rathmer, Stefan Heinrichs, Kenneth Burnside Ramsay Ewan, Tanja Bange, Trevor Clive Dale, Dennis Schade
Publikováno v:
Cell Chemical Biology, 24(8). Elsevier Inc.
Cell Chemical Biology
Dietrich, L, Rathmer, B, Ewan, K, Bange, T, Heinrichs, S, Dale, T C, Schade, D & Grossmann, T N 2017, ' Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions ', Cell Chemical Biology, vol. 24, no. 8, pp. 958–968 . https://doi.org/10.1016/j.chembiol.2017.06.013
Cell Chemical Biology
Dietrich, L, Rathmer, B, Ewan, K, Bange, T, Heinrichs, S, Dale, T C, Schade, D & Grossmann, T N 2017, ' Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions ', Cell Chemical Biology, vol. 24, no. 8, pp. 958–968 . https://doi.org/10.1016/j.chembiol.2017.06.013
The Wnt signaling pathway plays a critical role in cell proliferation and differentiation, thus it is often associated with diseases such as cancers. Unfortunately, although attractive, developing anti-cancer strategy targeting Wnt signaling has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed89a8e497dadd833adfe23fd93c5449
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85026256851
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85026256851
Autor:
Toby Roe, Will Court, Felix Rohdich, Julian Blagg, Wolfgang Kaufmann, Stefan Hecht, Richard Schneider, Stephen M. Hobbs, Christina Esdar, Alexis De Haven Brandon, Samer El Bawab, Phllip Hewitt, Suzanne A. Eccles, Kai Schiemann, Trevor Clive Dale, Paul Workman, Aurélie Mallinger, Stefan Weigt, Klaus Urbahns, Olajumoke Adeniji-Popoola, Andree Blaukat, Stephanie Simon, Robert TePoele, Melanie Valenti, Sharon Gowan, Stefanie Czasch, Paul A. Clarke, Gary Box, Dirk Wienke, Kenneth Burnside Ramsay Ewan, Maria-Jesus Ortiz-Ruiz, Florence I. Raynaud
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Mediator-associated kinases CDK8/19 are context-dependent drivers or suppressors of tumorigenesis. Their inhibition is predicted to have pleiotropic effects, but it is unclear whether this will impact on the clinical utility of CDK8/19 inhibitors. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320a3dd4067dcc727c7a6157a8004c42
http://europepmc.org/articles/PMC5224920
http://europepmc.org/articles/PMC5224920
Autor:
Andree Blaukat, Sharon Gowan, Richard Schneider, Suzanne A. Eccles, Gary Box, Dirk Wienke, Paul Workman, Robert TePoele, Stefan Hecht, Kai Schiemann, Trevor Clive Dale, Paul A. Clarke, Melanie Valenti, Toby Roe, Felix Rohdich, Wolfgang Kaufmann, Stephanie Czasch, Maria-Jesus Ortiz-Ruiz, Christina Esdar, Stefan Weigt, Kenneth Burnside Ramsay Ewan, Aurélie Mallinger, Alexis De Haven Brandon, Phillip Hewitt, Olajumoke Adeniji-Popoola, Will Court, Florence I. Raynaud, Stephen M. Hobbs, Stephanie Simon, Julian Blagg, Samer El Bawab, Klaus Urbahns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fdc132145578e222df38589324159b5
https://doi.org/10.7554/elife.20722.047
https://doi.org/10.7554/elife.20722.047
Publikováno v:
Current Drug Targets. 9:532-547
There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or dif- ferentiation. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::039e7241c1746e45ba5c1df4942074c2
https://doi.org/10.2174/138945008784911787
https://doi.org/10.2174/138945008784911787
Autor:
Nathalie Signoret, Kenneth Burnside Ramsay Ewan, Hugh Paterson, David Robertson, Matthew J. Smalley, Trevor Clive Dale, A. C. Hann, Alan Tilley, Yanning Ding
Publikováno v:
Journal of Cell Science. 118:5279-5289
Dishevelled family proteins are multidomain intracellular transducers of Wnt signals. Ectopically expressed mammalian Dishevelled 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta. It has been suggested that these Dvl-2-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d304e83ea6da86c70a8c48465f2a0c42
https://doi.org/10.1242/jcs.02647
https://doi.org/10.1242/jcs.02647
Autor:
Shradda A. Ravani, G. Shyamala, Mary Helen Barcellos-Hoff, Kenneth Burnside Ramsay Ewan, Rosemary J. Akhurst, Lalage M. Wakefield, Yang Tang
Publikováno v:
The American Journal of Pathology. 160:2081-2093
Transforming growth factor-beta1 (TGF-beta 1) is a pluripotent cytokine that can inhibit epithelial proliferation and induce apoptosis, but is also widely implicated in breast cancer progression. Understanding its biological action in mammary develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb8adc2f72cfc3313fb5b441bce0c7f
https://doi.org/10.1016/s0002-9440(10)61158-3
https://doi.org/10.1016/s0002-9440(10)61158-3