Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kenneth B. Rank"'
Autor:
Jennifer M Atkinson, Kenneth B Rank, Yi Zeng, Andrew Capen, Vipin Yadav, Jason R Manro, Thomas A Engler, Marcio Chedid
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125028 (2015)
It has previously been observed that a loss of β-catenin expression occurs with melanoma progression and that nuclear β-catenin levels are inversely proportional to cellular proliferation, suggesting that activation of the Wnt/β-catenin pathway ma
Externí odkaz:
https://doaj.org/article/1800f53a19f846dd955aa441443164bd
Autor:
Jennifer M. Atkinson, Jason Manro, Andrew Capen, Vipin Yadav, Thomas A. Engler, Yi Zeng, Kenneth B. Rank, Marcio Chedid
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0125028 (2015)
PLoS ONE, Vol 10, Iss 4, p e0125028 (2015)
It has previously been observed that a loss of β-catenin expression occurs with melanoma progression and that nuclear β-catenin levels are inversely proportional to cellular proliferation, suggesting that activation of the Wnt/β-catenin pathway ma
Autor:
David B. Evans, Adele M. Pauley, Keshab Bhattacharya, Zhigang Wang, Jennifer A Johnston, Satish K. Sharma, Kenneth B. Rank, Timothy J. Fleck
Publikováno v:
FEBS Letters. 514:263-268
We report here that aggregated beta-amyloid (Abeta) 1-42 promotes tau aggregation in vitro in a dose-dependent manner. When Abeta-mediated aggregated tau was used as a substrate for tau protein kinase II (TPK II), an 8-fold increase in the rate of TP
Publikováno v:
Biochemical and Biophysical Research Communications. 285:20-26
Filamentous tau pathology is central to a large number of dementing disorders, including Alzheimer's disease in which polymerized tau is hyperphosphorylated. Previous studies on heparin-dependent tau polymerization, using recombinant tau isoforms lac
Publikováno v:
Biochemical and Biophysical Research Communications. 271:469-473
It has been suggested that binding of p27 and p21 kinase inhibitory proteins (KIPs) to cyclin-dependent kinases (cdks) render them inaccessible to cdk-activating kinase (CAK), presumably by steric hindrance by the C-terminal residues. However, this c
Publikováno v:
Antiviral Research. 36:27-33
The human immunodeficiency virus-1 (HIV-1) integrase catalyzes the specific removal of two nucleotides at either 3′ end of each long terminal repeat (LTR) sequence of the proviral DNA duplex. The most commonly used in vitro assays for integrase emp
Autor:
Satish K. Sharma, Kenneth B. Rank, Carol A. Bannow, Joseph W. Leone, Alfredo G. Tomasselli, Donna J. Rothrock, Robert L. Heinrikson, Clark W. Smith, Susan M. Poppe, David B. Evans, Naisheng Fan, W. Gary Tarpley
Publikováno v:
Journal of Biological Chemistry. 270:13573-13579
Active, recombinant p68 reverse transcriptase (RT) from human immunodeficiency virus type 2 (HIV-2), with an NH2-terminal extension containing a hexahisti-dine sequence was isolated from extracts of Escherichia coli by immobilized metal affinity chro
Autor:
Kenneth B. Rank, Satish K. Sharma, Richard C. Thomas, Naisheng Fan, W. Gary Tarpley, David B. Evans
Publikováno v:
FEBS Letters. 359:233-238
Bisheteroarylpiperazines (BHAPs) are highly specific inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). BHAP-resistant HIV-1 is sensitized to other classes of nonnucleoside RT inhibitors and this has been primarily
Publikováno v:
Journal of biochemical and biophysical methods. 50(2-3)
Dysregulation of the brain-specific tau protein kinase II (TPK II)/cdk5 is reported to play an important role in the pathogenesis of Alzheimer's disease. We report here a quantitative scintillation proximity assay (SPA), which is suitable for determi
Autor:
Kenneth B. Rank, Kenneth A. Koeplinger, Joseph W. Leone, Ana M. Mildner, Kuo-Chen Chou, Alfredo G. Tomasselli, Satish K. Sharma, Robert L. Heinrikson
Publikováno v:
Protein expression and purification. 22(2)
We report here the cloning and high-level expression of a soluble proform of human caspase 3 (Ser(24)-H(277)) engineered to contain a short stretch of N-terminal sequence (MTISDSPREQD) from the prosegment of procaspase 8 and a C-terminal heptahistidi