Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kenneth B Hoehn"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1009885 (2022)
B cells undergo rapid mutation and selection for antibody binding affinity when producing antibodies capable of neutralizing pathogens. This evolutionary process can be intermixed with migration between tissues, differentiation between cellular subse
Externí odkaz:
https://doaj.org/article/f80d9eb2b1eb4157a215631796834c95
Autor:
Kenneth B Hoehn, Jackson S Turner, Frederick I Miller, Ruoyi Jiang, Oliver G Pybus, Ali H Ellebedy, Steven H Kleinstein
Publikováno v:
eLife, Vol 10 (2021)
The poor efficacy of seasonal influenza virus vaccines is often attributed to pre-existing immunity interfering with the persistence and maturation of vaccine-induced B cell responses. We previously showed that a subset of vaccine-induced B cell line
Externí odkaz:
https://doaj.org/article/a02d4d2d2cdd46088337aeb5a30242a5
Autor:
Felipe Lopes de Assis, Kenneth B. Hoehn, Xiaozhen Zhang, Lela Kardava, Connor D. Smith, Omar El Merhebi, Clarisa M. Buckner, Krittin Trihemasava, Wei Wang, Catherine A. Seamon, Vicky Chen, Paul Schaughency, Foo Cheung, Andrew J. Martins, Chi-I Chiang, Yuxing Li, John S. Tsang, Tae-Wook Chun, Steven H. Kleinstein, Susan Moir
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112780- (2023)
Summary: Protective immunity following vaccination is sustained by long-lived antibody-secreting cells and resting memory B cells (MBCs). Responses to two-dose SARS-CoV-2 mRNA-1273 vaccination are evaluated longitudinally by multimodal single-cell an
Externí odkaz:
https://doaj.org/article/0741d21fc63c4181b8b82bf41955424e
Autor:
Avraham Unterman, Tomokazu S. Sumida, Nima Nouri, Xiting Yan, Amy Y. Zhao, Victor Gasque, Jonas C. Schupp, Hiromitsu Asashima, Yunqing Liu, Carlos Cosme, Wenxuan Deng, Ming Chen, Micha Sam Brickman Raredon, Kenneth B. Hoehn, Guilin Wang, Zuoheng Wang, Giuseppe DeIuliis, Neal G. Ravindra, Ningshan Li, Christopher Castaldi, Patrick Wong, John Fournier, Santos Bermejo, Lokesh Sharma, Arnau Casanovas-Massana, Chantal B. F. Vogels, Anne L. Wyllie, Nathan D. Grubaugh, Anthony Melillo, Hailong Meng, Yan Stein, Maksym Minasyan, Subhasis Mohanty, William E. Ruff, Inessa Cohen, Khadir Raddassi, The Yale IMPACT Research Team, Laura E. Niklason, Albert I. Ko, Ruth R. Montgomery, Shelli F. Farhadian, Akiko Iwasaki, Albert C. Shaw, David van Dijk, Hongyu Zhao, Steven H. Kleinstein, David A. Hafler, Naftali Kaminski, Charles S. Dela Cruz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
SARS-CoV-2 infection can lead to progressive pathology in patients with COVID-19, but information for this disease progression is sparse. Here the authors use multi-omics approach to profile the immune responses of patients, assessing immune repertoi
Externí odkaz:
https://doaj.org/article/071dfec07b41418ab54ed9c36dc0d83e
Autor:
Line Ohm-Laursen, Hailong Meng, Kenneth B. Hoehn, Nima Nouri, Yue Jiang, Chris Clouser, Timothy G. Johnstone, Ron Hause, Balraj S. Sandhar, Nadine E. G. Upton, Elfy B. Chevretton, Raj Lakhani, Chris J. Corrigan, Steven H. Kleinstein, Hannah J. Gould
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In order to better understand how the immune system interacts with environmental triggers to produce organ-specific disease, we here address the hypothesis that B and plasma cells are free to migrate through the mucosal surfaces of the upper and lowe
Externí odkaz:
https://doaj.org/article/90d33209b9f84a22be9d4bd2b0aa8407
Autor:
Ruoyi Jiang, Hailong Meng, Khadir Raddassi, Ira Fleming, Kenneth B. Hoehn, Kenneth R. Dardick, Alexia A. Belperron, Ruth R. Montgomery, Alex K. Shalek, David A. Hafler, Steven H. Kleinstein, Linda K. Bockenstedt
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
The skin lesion erythema migrans (EM) is an initial sign of the Ixodes tick–transmitted Borreliella spirochetal infection known as Lyme disease. T cells and innate immune cells have previously been shown to predominate the EM lesion and promote the
Externí odkaz:
https://doaj.org/article/f707b263da164abface756aa19cc0bb0
Autor:
Kevin M. Nickerson, Shuchi Smita, Kenneth B. Hoehn, Anthony D. Marinov, Kayla B. Thomas, Justin T. Kos, Yi Yang, Sheldon I. Bastacky, Corey T. Watson, Steven H. Kleinstein, Mark J. Shlomchik
Publikováno v:
Journal of Experimental Medicine. 220
Age-associated B cells (ABCs) are formed under inflammatory conditions and are considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE, ABC frequency is correlated with disease, and they are thought to be the source
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31f4cf0433df6f2565b6ee8acd6a8f47
https://doi.org/10.1084/jem.20221346
https://doi.org/10.1084/jem.20221346
Autor:
Miyo Ota, Kenneth B. Hoehn, Takayuki Ota, Carlos J. Aranda, Sara Friedman, Weslley F. Braga, Alefiyah Malbari, Steven H. Kleinstein, Scott H. Sicherer, Maria A. Curotto de Lafaille
Publikováno v:
bioRxiv
Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23+IgG1+memory B cells arising in type 2 responses that contain p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593f4f5308c2746ec5b20a966bf36ab3
https://europepmc.org/articles/PMC9900782/
https://europepmc.org/articles/PMC9900782/
Autor:
Coraline Mlynarczyk, Matt Teater, Juhee Pae, Christopher R. Chin, Ling Wang, Theinmozhi Arulraj, Darko Barisic, Antonin Papin, Kenneth B. Hoehn, Ekaterina Kots, Jonatan Ersching, Arnab Bandyopadhyay, Ersilia Barin, Hui Xian Poh, Chiara M. Evans, Amy Chadburn, Zhengming Chen, Hao Shen, Hannah M. Isles, Benedikt Pelzer, Ioanna Tsialta, Ashley S. Doane, Huimin Geng, Muhammad Hassan Rehman, Jonah Melnick, Wyatt Morgan, Diu T. T. Nguyen, Olivier Elemento, Michael G. Kharas, Samie R. Jaffrey, David W. Scott, George Khelashvili, Michael Meyer-Hermann, Gabriel D. Victora, Ari Melnick
Publikováno v:
Science. 379
Multicellular life requires altruistic cooperation between cells. The adaptive immune system is a notable exception, wherein germinal center B cells compete vigorously for limiting positive selection signals. Studying primary human lymphomas and deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89af1728240b964263f280725c1cf48f
https://doi.org/10.1126/science.abj7412
https://doi.org/10.1126/science.abj7412
Autor:
Hiromitsu Asashima, Subhasis Mohanty, Michela Comi, William E. Ruff, Kenneth B. Hoehn, Patrick Wong, Jon Klein, Carolina Lucas, Inessa Cohen, Sarah Coffey, Nikhil Lele, Leissa Greta, Khadir Raddassi, Omkar Chaudhary, Avraham Unterman, Brinda Emu, Steven H. Kleinstein, Ruth R. Montgomery, Akiko Iwasaki, Charles S. Dela Cruz, Naftali Kaminski, Albert C. Shaw, David A. Hafler, Tomokazu S. Sumida
Publikováno v:
Cell Reports. 42:111895
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49077e4649404726487e7dc262a650cf
https://doi.org/10.1016/j.celrep.2022.111895
https://doi.org/10.1016/j.celrep.2022.111895