Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kenneth Alves"'
Autor:
Kelly M. Treonze, Russell B. Lingham, Richard A. Mumford, Kenneth Alves, Benito Munoz, Weichao Chen, Joyce P. James, Jasmine Zunic, Nicholas D. Smith, Thomas S. Reger, Bowei Wang, Michael F. Gardner, Nicholas Stock, Mitchell D. Green, Qian Si
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1173-1176
A variety of N-linked tertiary amines and heteroarylamines were examined at the 4-position of sulfonylated proline dipeptides in order to improve VLA-4 receptor off-rates and overcome the issue of CYP3A4 time-dependent inhibition of ester prodrugs. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418233da95288470cb2c8fbb4c8b2413
https://doi.org/10.1016/j.bmcl.2009.12.009
https://doi.org/10.1016/j.bmcl.2009.12.009
Autor:
Salony Maniar, Russell B. Lingham, Benito Munoz, Michael F. Gardner, Kenneth Alves, Alec D. Lebsack, Shankar Venkatraman, Joyce K. James, Qian Si, Bowei Wang, Richard A. Mumford, Nicholas Stock, Kelly M. Treonze, Jasmine Zunic
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5803-5806
A series of prolyl-N-isonicotinoyl-(L)-4-aminophenylalanine derivatives substituted at the proline 4-position with cyclic amines was evaluated as VLA-4 antagonists. The ring size and presence or absence of fluorine affected potency and receptor occup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab26f3bff50ff8e8ec08ba0ecbfbcc77
https://doi.org/10.1016/j.bmcl.2009.07.111
https://doi.org/10.1016/j.bmcl.2009.07.111
Autor:
Kenneth Alves, Thomas S. Reger, Kelly M. Treonze, Susan Nicolich, Patricia Kellerhouse, Salony Maniar, Paul A. Fischer, Donald W. Nicholson, Jasmine Zunic, Russell B. Lingham, Donald F. Hora, Peppi Prasit, Nicholas D. Smith, Richard A. Mumford, Keith Judd, Alison A. Kulick, Donald Thompson, Qian Si, William K. Hagmann, Benito Munoz, Ken Vakerich
Publikováno v:
Veterinary Immunology and Immunopathology. 130:79-87
The purpose of this study was to characterize the alpha(4)beta(1) receptor (CD49d/CD29, very late antigen-4, VLA-4) on circulating equine leukocytes and to evaluate the intrinsic potency of an alpha(4)beta(1) receptor antagonist (Compound B) in the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2519d0b2f73ce500e2d2ca3d32c8e1
https://doi.org/10.1016/j.vetimm.2009.01.011
https://doi.org/10.1016/j.vetimm.2009.01.011
Autor:
Benito Munoz, Jongwon Lim, Shankar Venkatraman, Russell B. Lingham, Merryl Cramer, Richard A. Mumford, Michael F. Gardner, Joyce K. James, Kenneth Alves
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4053-4056
A series of VLA-4 antagonist were synthesized wherein carboxylic acid was replaced by various acid surrogates. The effect of these acid surrogates toward potency was evaluated in a binding assay. A number of acid surrogates were potent antagonist of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1e886282db3d7c92bc83ac7e0d29cb
https://doi.org/10.1016/j.bmcl.2005.06.034
https://doi.org/10.1016/j.bmcl.2005.06.034
Autor:
Jwu-Sheng Tung, Kathryn L. Jones, Christine P. Chan, Gregory F. Hollis, David L. Williams, Kenneth Alves
Publikováno v:
Life Sciences. 53:407-414
Two subtypes of human endothelin receptors, ET A and ET B , have been cloned and stably expressed in Chinese Hamster Ovary cells. These receptors have been characterized by [ 125 I]-endothelin-1 binding and phosphatidyl inositol hydrolysis using the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145d7be01cf106446707c9b8c1cbe72a
https://doi.org/10.1016/0024-3205(93)90644-i
https://doi.org/10.1016/0024-3205(93)90644-i
Autor:
Beth Junker, D. Jain, K. Ramasubramanyan, Albert B. Lenny, Jwu-Sheng Tung, Gregory C. Cuca, Michael R. Tota, Catherine D. Strader, M R Candelore, Kenneth Alves, Sandra L. Gould, G. Hunt, Melvin Silberklang, Barry C. Buckland
We have used the recombinant baculovirus expression vector system, based on Autographa californica Nuclear Polyhedrosis Virus (AcMNPV) grown in Spodoptera frugiperda (Sf9) insect cells, to produce three proteins: antistasin, half-antistasin, and β-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cbe353d72eff4ea1074fae434ab8534
https://doi.org/10.1016/b978-0-7506-1103-9.50068-8
https://doi.org/10.1016/b978-0-7506-1103-9.50068-8
