Zobrazeno 1 - 10
of 798
pro vyhledávání: '"Kenneth A. Wilson"'
Autor:
Tyler A. U. Hilsabeck, Vikram P. Narayan, Kenneth A. Wilson, Enrique M. Carrera, Daniel Raftery, Daniel Promislow, Rachel B. Brem, Judith Campisi, Pankaj Kapahi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Dietary restriction (DR) is a potent method to enhance lifespan and healthspan, but individual responses are influenced by genetic variations. Understanding how metabolism-related genetic differences impact longevity and healthspan are uncle
Externí odkaz:
https://doaj.org/article/1269ea70807c4fd9a21d7ad062523697
Autor:
Kenneth A. Wilson, Sudipta Bar, Eric B. Dammer, Enrique M. Carrera, Brian A. Hodge, Tyler A. U. Hilsabeck, Joanna Bons, George W. Brownridge, Jennifer N. Beck, Jacob Rose, Melia Granath-Panelo, Christopher S. Nelson, Grace Qi, Akos A. Gerencser, Jianfeng Lan, Alexandra Afenjar, Geetanjali Chawla, Rachel B. Brem, Philippe M. Campeau, Hugo J. Bellen, Birgit Schilling, Nicholas T. Seyfried, Lisa M. Ellerby, Pankaj Kapahi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediat
Externí odkaz:
https://doaj.org/article/3db7a1cee89643b094c27462834817ac
Autor:
Maria Esteban-Lopez, Kenneth J. Wilson, Courtney Myhr, Elena M. Kaftanovskaya, Mark J. Henderson, Noel T. Southall, Xin Xu, Amy Wang, Xin Hu, Elena Barnaeva, Wenjuan Ye, Emmett R. George, John T. Sherrill, Marc Ferrer, Roy Morello, Irina U. Agoulnik, Juan J. Marugan, Alexander I. Agoulnik
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Specific small molecule RXFP2 agonists with favorable pharmacokinetic properties induce gubernacular invagination in mouse embryos, increase mineralization activity in human osteoblasts in vitro, and improve bone trabecular parameters in adult mice.
Externí odkaz:
https://doaj.org/article/50c86baebeb04e3ebabf87beea0be0a0
Autor:
Kelly Jin, Kenneth A Wilson, Jennifer N Beck, Christopher S Nelson, George W Brownridge, Benjamin R Harrison, Danijel Djukovic, Daniel Raftery, Rachel B Brem, Shiqing Yu, Mathias Drton, Ali Shojaie, Pankaj Kapahi, Daniel Promislow
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010199 (2022)
[This corrects the article DOI: 10.1371/journal.pgen.1008835.].
Externí odkaz:
https://doaj.org/article/ad329b2a6af542fbad06457516131dc0
Autor:
Nicola Karen Abram, Hong Ye Lim, Casey Keat-Chuan Ng, Sylvia Yorath, Mohamed Haleem Mohamed Razi, Cynthia Gaik Suan Ong, Kok-On Chen, Kenneth Brockington Wilson
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269890 (2022)
Road and highway development can provide multiple benefits to society, but without careful planning, this development can result in negative social and environmental impacts. The 1,200 km Pan Borneo Highway project (PBH) in Sabah, Malaysian Borneo, i
Externí odkaz:
https://doaj.org/article/837dc8f3f2d5412c9fba7c64a4cae2a4
Autor:
Hooi Hooi Ng, Mariluz Soula, Bryan Rivas, Kenneth J. Wilson, Juan J. Marugan, Alexander I. Agoulnik
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Diseases, such as diabetes and hypertension, often lead to chronic kidney failure. The peptide hormone relaxin has been shown to have therapeutic effects in various organs. In the present study, we tested the hypothesis that ML290, a small molecule a
Externí odkaz:
https://doaj.org/article/586332c3834942cb94cf7cf198c3c572
Autor:
Lisa B. E. Shields, Paula Fowler, Diane M. Siemens, Douglas J. Lorenz, Kenneth C. Wilson, Steven T. Hester, Joshua T. Honaker
Publikováno v:
BMC Family Practice, Vol 20, Iss 1, Pp 1-7 (2019)
Abstract Background While warfarin is the most commonly prescribed medication to prevent thromboembolic disorders, the risk of adverse drug reactions (ADR) poses a serious concern. This prospective study evaluated how primary care providers (PCP) and
Externí odkaz:
https://doaj.org/article/88492afb71114628924a17ed3174395b
Autor:
Tareq Maraqa, Mohamed A. T. Mohamed, Kenneth L. Wilson, Vinu Perinjelil, Gul R. Sachwani-Daswani, Leo Mercer
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 14, Iss 1, Pp 1-7 (2019)
Abstract Background Isolated right atrial rupture (IRAR) from blunt chest trauma is rare. There are no physical exam findings and non-invasive testing specific to the condition, which result in diagnostic delays and poor outcomes. We present a case o
Externí odkaz:
https://doaj.org/article/e3ed122e33f342668e8afb23feb2fcd6
Autor:
Rachel C. Newsome, Josee Gauthier, Maria C. Hernandez, George E. Abraham, Tanya O. Robinson, Haley B. Williams, Meredith Sloan, Anna Owings, Hannah Laird, Taylor Christian, Yilianys Pride, Kenneth J. Wilson, Mohammad Hasan, Adam Parker, Michal Senitko, Sarah C. Glover, Raad Z. Gharaibeh, Christian Jobin
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
To investigate the relationship between intestinal microbiota and SARS-CoV-2-mediated pathogenicity in a United States, majority African American cohort. We prospectively collected fecal samples from 50 SARS-CoV-2 infected patients, 9 SARS-CoV-2 reco
Externí odkaz:
https://doaj.org/article/96685b2fdf614995a7d3332aa38157fb
Autor:
Kelly Jin, Kenneth A Wilson, Jennifer N Beck, Christopher S Nelson, George W Brownridge, Benjamin R Harrison, Danijel Djukovic, Daniel Raftery, Rachel B Brem, Shiqing Yu, Mathias Drton, Ali Shojaie, Pankaj Kapahi, Daniel Promislow
Publikováno v:
PLoS Genetics, Vol 16, Iss 7, p e1008835 (2020)
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbr
Externí odkaz:
https://doaj.org/article/6d326a104228454ab46f83d17100e162