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pro vyhledávání: '"Kenneth A. Laderman"'
Publikováno v:
Somatic Cell and Molecular Genetics. 25:333-342
Previous work had shown a large accumulation (up to 50% of mtDNA) of a noninherited T414G transversion at a critical control site for mtDNA replication in skin fibroblasts from the majority of human subjects above 65 years old, and its absence in you
Autor:
Franca Mazzucchelli, Guglielmo Scarlato, Kenneth A. Laderman, Giuseppe Attardi, Nereo Bresolin, James R. Penny
Publikováno v:
The Journal of biological chemistry. 271(27)
To investigate the role that aging-dependent accumulation of mitochondrial DNA (mtDNA) mutations plays in the senescence processes, mitochondria from fibroblasts of 21 normal human individuals between 20 weeks (fetal) and 103 years of age were introd