Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Kenneth A Matreyek"'
Autor:
Nidhi Shukla, Sarah M Roelle, John C Snell, Olivia DelSignore, Anna M Bruchez, Kenneth A Matreyek
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012044 (2024)
Pairwise compatibility between virus and host proteins can dictate the outcome of infection. During transmission, both inter- and intraspecies variabilities in receptor protein sequences can impact cell susceptibility. Many viruses possess mutable vi
Externí odkaz:
https://doaj.org/article/67489a10be4e47bcb742e81b6191bf36
Publikováno v:
PLoS Biology, Vol 20, Iss 7, p e3001738 (2022)
Viral spillover from animal reservoirs can trigger public health crises and cripple the world economy. Knowing which viruses are primed for zoonotic transmission can focus surveillance efforts and mitigation strategies for future pandemics. Successfu
Externí odkaz:
https://doaj.org/article/6e470d8c7ab040b4aa6dbc362e480cd1
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009715 (2021)
SARS-CoV and SARS-CoV-2 encode spike proteins that bind human ACE2 on the cell surface to enter target cells during infection. A small fraction of humans encode variants of ACE2, thus altering the biochemical properties at the protein interaction int
Externí odkaz:
https://doaj.org/article/b24b1b17e9394e79b3edd58c9a75cd92
Autor:
Melissa A Chiasson, Nathan J Rollins, Jason J Stephany, Katherine A Sitko, Kenneth A Matreyek, Marta Verby, Song Sun, Frederick P Roth, Daniel DeSloover, Debora S Marks, Allan E Rettie, Douglas M Fowler
Publikováno v:
eLife, Vol 9 (2020)
Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant drug, warfarin. Despite VKOR’s pivotal role in coagulation, its structure
Externí odkaz:
https://doaj.org/article/36b421f0fd264b0f97e516ab449e0b61
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003693 (2013)
Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide crucial functions for lentiviral nuclear entry and integration. We previously showed that the viral capsid (CA) protein mediated the dependency on cellular nu
Externí odkaz:
https://doaj.org/article/35e2d4e6a99d4c6c99a3bec7f47fce89
Autor:
Tyler N. Starr, Allison J. Greaney, William W. Hannon, Andrea N. Loes, Kevin Hauser, Josh R. Dillen, Elena Ferri, Ariana Ghez Farrell, Bernadeta Dadonaite, Matthew McCallum, Kenneth A. Matreyek, Davide Corti, David Veesler, Gyorgy Snell, Jesse D. Bloom
Publikováno v:
Science. 377:420-424
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin-converting enzyme 2 (ACE2) receptor and recognition by antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1c8a39dffec354987cb14b4eeb5686
https://doi.org/10.1126/science.abo7896
https://doi.org/10.1126/science.abo7896
Autor:
Ayesha Muhammad, Maria E. Calandranis, Bian Li, Tao Yang, Daniel J. Blackwell, M. Lorena Harvey, Jeremy E. Smith, Ashli E. Chew, John A. Capra, Kenneth A. Matreyek, Douglas M. Fowler, Dan M. Roden, Andrew M. Glazer
Publikováno v:
bioRxiv
BackgroundKCNE1encodes a 129-residue cardiac potassium channel (IKs) subunit. KCNE1 variants are associated with long QT syndrome and atrial fibrillation. However, most variants have insufficient evidence of clinical consequences and thus limited cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9295df36fc7c8321c5c4fd825255bb6
https://europepmc.org/articles/PMC10168370/
https://europepmc.org/articles/PMC10168370/
Autor:
Timothy J. C. Tan, Zongjun Mou, Ruipeng Lei, Wenhao O. Ouyang, Meng Yuan, Ge Song, Raiees Andrabi, Ian A. Wilson, Collin Kieffer, Xinghong Dai, Kenneth A. Matreyek, Nicholas C. Wu
Publikováno v:
bioRxiv
Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to stabilize its prefusion conformation. However, contemporary methods on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ca81e5509569d603e225ab7b2fd64b
https://doi.org/10.1038/s41467-023-37786-1
https://doi.org/10.1038/s41467-023-37786-1
Autor:
Christopher J.R. Loewen, Calvin D. Roskelley, Kurt Haas, Douglas M. Fowler, Pamela Dean, Kenneth A. Matreyek, Fabian Meili, Warren M. Meyers, Rocio Hollman, Jesse T. Chao
Table S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773650e003ac15aa4e5007f3034f8caa
https://doi.org/10.1158/0008-5472.22424944
https://doi.org/10.1158/0008-5472.22424944
Autor:
Christopher J.R. Loewen, Calvin D. Roskelley, Kurt Haas, Douglas M. Fowler, Pamela Dean, Kenneth A. Matreyek, Fabian Meili, Warren M. Meyers, Rocio Hollman, Jesse T. Chao
Supplemental Figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a20b96d1d0a21d2f013575b1cb049e
https://doi.org/10.1158/0008-5472.22424950.v1
https://doi.org/10.1158/0008-5472.22424950.v1