Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Kenneth A, Platt"'
Autor:
Christopher M. DaCosta, Robert Brommage, Isaac Van Sligtenhorst, Zhi-Ming Ding, Gwenn M. Hansen, Kenneth A. Platt, Jean-Pierre Revelli, Deon Doree, David R. Powell
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:2641-2652
Purpose In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1241da8071ecf353792b00269b89ba
https://doi.org/10.2147/dmso.s259546
https://doi.org/10.2147/dmso.s259546
Autor:
David R Powell, Deon D Doree, Christopher M DaCosta, Kenneth A Platt, Robert Brommage, Lindsey Buhring, Jean-Pierre Revelli, Melanie K Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.
David R Powell,1 Deon D Doree,1 Christopher M DaCosta,1 Kenneth A Platt,2 Robert Brommage,1 Lindsey Buhring,1 Jean-Pierre Revelli,1 Melanie K Shadoan1 1Department of Pharmaceutical Biology, Lexicon Pharmaceuticals, Inc, The Woodlands, TX, USA; 2Depar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33643fb27a8877ae6bb4e8757ee67c5
https://www.dovepress.com/mice-lacking-gpr75-are-hypophagic-and-thin-peer-reviewed-fulltext-article-DMSO
https://www.dovepress.com/mice-lacking-gpr75-are-hypophagic-and-thin-peer-reviewed-fulltext-article-DMSO
Autor:
David R, Powell, Deon D, Doree, Christopher M, DaCosta, Kenneth A, Platt, Robert, Brommage, Lindsey, Buhring, Jean-Pierre, Revelli, Melanie K, Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Purpose Humans with haploinsufficiency of GPR75, an orphan GPCR, are thin. Gpr75 knockout (KO) mice are also thin with improved glucose homeostasis. We wanted to confirm these findings in Gpr75 KO mice and determine whether decreased energy intake an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::297a542c63b91289d72014b3b34f4748
https://pubmed.ncbi.nlm.nih.gov/35023939
https://pubmed.ncbi.nlm.nih.gov/35023939
Autor:
Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://doaj.org/article/1dff52e3692941429b8b20d7536589fd
Autor:
David R, Powell, Deon D, Doree, Christopher M, DaCosta, Kenneth A, Platt, Gwenn M, Hansen, Isaac, van Sligtenhorst, Zhi-Ming, Ding, Jean-Pierre, Revelli, Robert, Brommage
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Purpose In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11ad3ff60e157b814ea6ccc362bf14f8
https://pubmed.ncbi.nlm.nih.gov/32801815
https://pubmed.ncbi.nlm.nih.gov/32801815
Autor:
Wandong Zhang, Katerina V Savelieva, David T Tran, Vladimir M Pogorelov, Emily B Cullinan, Kevin B Baker, Kenneth A Platt, Sean Hu, Indrani Rajan, Nianhua Xu, Thomas H Lanthorn
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45500 (2012)
Receptor tyrosine phosphatase gamma (PTPRG, or RPTPγ) is a mammalian receptor-like tyrosine phosphatase which is highly expressed in the nervous system as well as other tissues. Its function and biochemical characteristics remain largely unknown. We
Externí odkaz:
https://doaj.org/article/49ec46596bfb4c59a97152346a0796f2
Autor:
Kristen E. Syring, Kayla A. Boortz, James K. Oeser, David W. Piston, Owen P. McGuinness, Melanie K. Shadoan, Richard M. O'Brien, David R. Powell, Kenneth A. Platt, Alessandro Ustione
Publikováno v:
Endocrinology. 157:4534-4541
Polymorphisms in the SLC30A8 gene, which encodes the ZnT8 zinc transporter, are associated with altered susceptibility to type 2 diabetes (T2D), and SLC30A8 haploinsufficiency is protective against the development of T2D in obese humans. SLC30A8 is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde0820ca2641d0119bb7c5e64311bc3
https://doi.org/10.1210/en.2016-1573
https://doi.org/10.1210/en.2016-1573
Autor:
Kenneth B. Platt, Bradley J. Tucker, Patrick G. Halbur, Sonthaya Tiawsirisup, Bradley J. Blitvich, Flor G. Fabiosa, Lyric C. Bartholomay, Wayne A. Rowley
Publikováno v:
Emerging Infectious Diseases, Vol 13, Iss 6, Pp 831-831 (2007)
In eastern chipmunks (Tamias striatus) inoculated intramuscularly with 101.5 to 105.7 PFU of West Nile virus (WNV), serum titers developed sufficient to infect Aedes triseriatus (Say), Ae. vexans (Meigen), and Culex pipiens (L.). Mean titers (95% con
Externí odkaz:
https://doaj.org/article/41344cb4e91649ed871120ffc35b64ea
Autor:
Takahiro Masuda, Timo Rieg, David R. Powell, Eric Mayoux, Hermann Koepsell, Kenneth A. Platt, Maria Gerasimova, Scott C. Thomson, Volker Vallon
Publikováno v:
American Journal of Physiology-Renal Physiology. 306:F188-F193
In the kidney, the sodium-glucose cotransporters SGLT2 and SGLT1 are thought to account for >90 and ∼3% of fractional glucose reabsorption (FGR), respectively. However, euglycemic humans treated with an SGLT2 inhibitor maintain an FGR of 40–50%,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0877a1a19b54edc7cedc5de18081f2b6
https://doi.org/10.1152/ajprenal.00518.2013
https://doi.org/10.1152/ajprenal.00518.2013