Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Kenneth A, Pelkey"'
Autor:
Chad R. Camp, Anna Vlachos, Chiara Klöckner, Ilona Krey, Tue G. Banke, Nima Shariatzadeh, Sarah M. Ruggiero, Peter Galer, Kristen L. Park, Adam Caccavano, Sarah Kimmel, Xiaoqing Yuan, Hongjie Yuan, Ingo Helbig, Tim A. Benke, Johannes R. Lemke, Kenneth A. Pelkey, Chris J. McBain, Stephen F. Traynelis
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate a calcium-permeable component to fast excitatory neurotransmission. NMDARs are heterotetrameric assemblies of two obligate GluN1 subunits (G
Externí odkaz:
https://doaj.org/article/cf7691bd122c40aa8eaf85252a89fb91
Autor:
Connie A. Mackenzie-Gray Scott, Kenneth A. Pelkey, Adam P. Caccavano, Daniel Abebe, Mandy Lai, Khayla N. Black, Nicolette D. Brown, Andrew J. Trevelyan, Chris J. McBain
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN) function as a precipitating factor underlying abnormalities in network synchrony, oscillatory rhythms, and cognition associated with Alzheimer’s disease (AD). Howev
Externí odkaz:
https://doaj.org/article/66eb1801a57143f6b4eb79122b3f5186
Autor:
Vivek Mahadevan, Apratim Mitra, Yajun Zhang, Xiaoqing Yuan, Areg Peltekian, Ramesh Chittajallu, Caroline Esnault, Dragan Maric, Christopher Rhodes, Kenneth A. Pelkey, Ryan Dale, Timothy J. Petros, Chris J. McBain
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Medial ganglionic eminence (MGE)-derived parvalbumin (PV)+, somatostatin (SST)+and Neurogliaform (NGFC)-type cortical and hippocampal interneurons, have distinct molecular, anatomical, and physiological properties. However, the molecular mechanisms r
Externí odkaz:
https://doaj.org/article/34105da8a8c34caa8b97c6a66402c331
Autor:
Ramesh Chittajallu, Kurt Auville, Vivek Mahadevan, Mandy Lai, Steven Hunt, Daniela Calvigioni, Kenneth A Pelkey, Kareem A Zaghloul, Chris J McBain
Publikováno v:
eLife, Vol 9 (2020)
The ability to modulate the efficacy of synaptic communication between neurons constitutes an essential property critical for normal brain function. Animal models have proved invaluable in revealing a wealth of diverse cellular mechanisms underlying
Externí odkaz:
https://doaj.org/article/dca55f11b3904168b078fc32d3305771
Autor:
Kenneth A Pelkey, Daniela Calvigioni, Calvin Fang, Geoffrey Vargish, Tyler Ekins, Kurt Auville, Jason C Wester, Mandy Lai, Connie Mackenzie-Gray Scott, Xiaoqing Yuan, Steven Hunt, Daniel Abebe, Qing Xu, Jordane Dimidschstein, Gordon Fishell, Ramesh Chittajallu, Chris J McBain
Publikováno v:
eLife, Vol 9 (2020)
In violation of Dale’s principle several neuronal subtypes utilize more than one classical neurotransmitter. Molecular identification of vesicular glutamate transporter three and cholecystokinin expressing cortical interneurons (CCK+VGluT3+INTs) ha
Externí odkaz:
https://doaj.org/article/2d6dd0a8319a4710bdf70792ee91be46
Autor:
Megan S. Wyeth, Kenneth A. Pelkey, Xiaoqing Yuan, Geoffrey Vargish, April D. Johnston, Steven Hunt, Calvin Fang, Daniel Abebe, Vivek Mahadevan, André Fisahn, Michael W. Salter, Roderick R. McInnes, Ramesh Chittajallu, Chris J. McBain
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2156-2168 (2017)
Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited. Because Neto KAR regulation is GluK subunit/Neto isoform specific, such regulation must be
Externí odkaz:
https://doaj.org/article/7da6c7288bdf4d1f9ddc05359a142310
Autor:
Emmie Banks, Claire-Anne Gutekunst, Geoffrey A. Vargish, Anna Eaton, Kenneth A. Pelkey, Chris J. McBain, James Q. Zheng, Viktor Janos Oláh, Matthew JM Rowan
Publikováno v:
bioRxiv
SummaryThe mammalian brain contains the most diverse array of cell types of any organ, including dozens of neuronal subtypes with distinct anatomical and functional characteristics. The brain leverages these neuron-type-specializations to perform div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4500cb092b7201be8b0254aff475ab0
https://doi.org/10.1101/2023.02.03.527045
https://doi.org/10.1101/2023.02.03.527045
Autor:
Kenneth A. Pelkey, Geoffrey Vargish, Leonardo Pellegrini, Daniela Calvigioni, Julio Chapeton, Xiaoqing Yuan, Steven Hunt, Alexander Cummins, Mark Eldridge, James Pickel, Ramesh Chittajallu, Bruno Averbeck, Katalin Toth, Kareem Zaghloul, Chris McBain, Sneak Peek Administrator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d66a46052145fc19d8e7af3b7eda7c71
https://doi.org/10.2139/ssrn.4354091
https://doi.org/10.2139/ssrn.4354091
Autor:
Mei-Fang Xiao, Desheng Xu, Michael T Craig, Kenneth A Pelkey, Chun-Che Chien, Yang Shi, Juhong Zhang, Susan Resnick, Olga Pletnikova, David Salmon, James Brewer, Steven Edland, Jerzy Wegiel, Benjamin Tycko, Alena Savonenko, Roger H Reeves, Juan C Troncoso, Chris J McBain, Douglas Galasko, Paul F Worley
Publikováno v:
eLife, Vol 6 (2017)
Memory loss in Alzheimer’s disease (AD) is attributed to pervasive weakening and loss of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons of the hippocampus and cortex with fast-spik
Externí odkaz:
https://doaj.org/article/c08345d0049e4dd1b942103924533d4a
Autor:
Douglas Vormstein-Schneider, John V. Reynolds, Zhanyan Fu, Xiaoqing Yuan, Qiangge Zhang, Jared B. Smith, Giuseppe A. Saldi, Vanessa Sanchez, Jitendra Sharma, Gates Schneider, Renata Batista-Brito, Josselyn Vergara, Kareem A. Zaghloul, Jessica Lin, Orrin Devinsky, Timothy Burbridge, Kathryn C. Allaway, Leena A. Ibrahim, Sofia Sakopoulos, Guoping Feng, Emilia Favuzzi, Jordane Dimidschstein, Bram L. Gorissen, Tom P. Franken, Baolin Guo, Gord Fishell, Mario A. Arias-Garcia, Shuhan Huang, Bernardo L. Sabatini, Ramesh Chittajallu, Olivia Stevenson, Kenneth A. Pelkey, Chris J. McBain, Ian Vogel, Qing Xu, Ehsan Sabri, Lihua Guo, Kevin J. M astro
Publikováno v:
Nature Neuroscience. 23:1629-1636
Recent success in identifying gene-regulatory elements in the context of recombinant adeno-associated virus vectors has enabled cell-type-restricted gene expression. However, within the cerebral cortex these tools are largely limited to broad classes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffd8a5ada95002017685b74815a0c1da
https://doi.org/10.1038/s41593-020-0692-9
https://doi.org/10.1038/s41593-020-0692-9