Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kenneth A, Newlander"'
Autor:
Christine Thompson, Daryl A. Scherzer, Ryan G. Kruger, Steven D. Knight, Louis V. LaFrance, Heidi M. Ott, Dashyant Dhanak, Stuart Paul Romeril, Celine Duquenne, Dominic Suarez, William H. Miller, Art Shu, Seth W. Grant, Carl A. Machutta, Joelle Lorraine Burgess, Brackley James, Caretha L. Creasy, Xinrong Tian, Yong Jiang, Sharad K. Verma, Peter J. Tummino, Alan P. Graves, Glenn S. Van Aller, Elsie Diaz, Kenneth A. Newlander, Johnson Neil W, Michael T. McCabe
Publikováno v:
ACS Medicinal Chemistry Letters. 3:1091-1096
The histone H3-lysine 27 (H3K27) methyltransferase EZH2 plays a critical role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. As part of a drug discovery program targeting EZH2, we have ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09381bbf91f7d5cc9197b3635203cdfa
https://doi.org/10.1021/ml3003346
https://doi.org/10.1021/ml3003346
Autor:
William H. Miller, Frank Fan, Nicola G. Wallis, Mark A. Seefeld, Walter E. DeWolf, Martha S. Head, David J. Payne, Damien McDevitt, Jianzhong Huang, Terrance D. Moore, Dalia R. Jakas, Kenneth A. Newlander, Kang Yan, Stephen Rittenhouse, Shannon L. Reed
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:3343-3347
The MICs of triclosan for 31 clinical isolates of Staphylococcus aureus were 0.016 μg/ml (24 strains), 1 to 2 μg/ml (6 strains), and 0.25 μg/ml (1 strain). All the strains for which triclosan MICs were elevated (>0.016 μg/ml) showed three- to fiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879a7942d797b09906006e82d2eceb24
https://doi.org/10.1128/aac.46.11.3343-3347.2002
https://doi.org/10.1128/aac.46.11.3343-3347.2002
Autor:
William H. Miller, Catherine C.K. Yuan, Kalindi Vaidya, Brian J. Polizzi, Dennis T. Takata, Rebecca Claire Greenwood, Dirk A. Heerding, Mark A. Seefeld, Scott B. Winram, Valerie Berry, Martha S. Head, Walter J. Burgess, Andrew P. Fosberry, Nicola G. Wallis, David J. Payne, Stephen Rittenhouse, William F. Huffman, Paul M. Keller, Kevin L. Salyers, Manley Peter J, Kenneth A. Newlander, Deborah Dee Jaworski, Courtney Slater-Radosti, Cheryl A. Janson, Walter E. DeWolf, Irene N. Uzinskas, John Brosky, Stewart C. Pearson, Xiayang Qiu, Emile Chen, Terrance D. Moore, Martin G. Smyth
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:3118-3124
Bacterial enoyl-acyl carrier protein (ACP) reductase (FabI) catalyzes the final step in each elongation cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. High-throughput screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997a68e3d46cb5b0dd9196003827969e
https://doi.org/10.1128/aac.46.10.3118-3124.2002
https://doi.org/10.1128/aac.46.10.3118-3124.2002
Autor:
William F. Huffman, Paul M. Keller, Valerie Berry, Walter E. DeWolf, William H. Miller, Catherine C.K. Yuan, Mark A. Seefeld, Stephen Rittenhouse, Brian J. Polizzi, Stewart C. Pearson, Cheryl A. Janson, Dirk A. Heerding, Walter J. Burgess, Martha S. Head, Terrance D. Moore, Kenneth A. Newlander, Xiayang Qiu, Irene N. Uzinskas, David J. Payne
Publikováno v:
Journal of Medicinal Chemistry. 45:3246-3256
Bacterial enoyl-ACP reductase (FabI) catalyzes the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. Our eff...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac5be10717eef2aed6ee5bf83df2f1ef
https://doi.org/10.1021/jm020050+
https://doi.org/10.1021/jm020050+
Autor:
Kenneth A. Newlander, Kalindi Vaidya, William F. Huffman, William H. Miller, Paul M. Keller, Walter E. DeWolf, Terrance D. Moore, Xiayang Qiu, Courtney Slater-Radosti, Cheryl A. Janson, Mark A. Seefeld, Martin G. Smyth, David J. Payne, Deborah Dee Jaworski, Andrew P. Fosberry, Walter J. Burgess, Stephen Rittenhouse
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2241-2244
An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as inhibitors of Staphylococcus aureus enoyl acyl carrier protein reductase (FabI).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7905df83251b089a15bd4bfe57170a3f
https://doi.org/10.1016/s0960-894x(01)00405-x
https://doi.org/10.1016/s0960-894x(01)00405-x
Autor:
Irene N. Uzinskas, Kyung O. Johanson, William F. Huffman, R. D. Cousins, William E. Bondinell, Stephen T. Ross, M.W. Lark, Keith W. Ward, Chuan-Kui Yuan, Kevin L. Salyers, Dirk A. Heerding, S M Hwang, Joseph W. Venslavsky, J. Samanen, Karl F. Erhard, Raul R. Calvo, M. Gowen, Pradip K. Bhatnagar, James F. Callahan, Manley Peter J, Doreen Alberts, Brian R. Smith, Kenneth A. Newlander, W.H. Miller, R. C. Haltiwanger, Richard M. Keenan, George B. Stroup, David J. Rieman, Chet Kwon, Leonard M. Azzarano, Ian E. James
Publikováno v:
Journal of Medicinal Chemistry. 43:22-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921ed25c145b5edbd1b8a614916fc7cc
https://doi.org/10.1021/jm990446u
https://doi.org/10.1021/jm990446u
Autor:
David J. Rieman, William F. Huffaman, Kevin L. Salyers, Richard M. Keenan, Michael W. Lark, Janice A. Vasko-Moser, Thomas W. Ku, Maxine Gowen, Leonard M. Azzarano, Karl F. Erhard, Stephen T. Ross, Denise Zembryki, Bradbeer Jeremy N, Bondinell William E, Shing-Mei Hwang, William H. Miller, Kenneth A. Newlander, George B. Stroup, Beata Lechowska, Fred H. Drake, Keith W. Ward, Kyung O. Johanson, Brian R. Smith, Paula C. Adams, Ian E. James, R. Curtis Haltiwanger, Russell D. Cousins, Dalia R. Jakas, Sandra J. Hoffman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1807-1812
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bebe15e69e0b6c6398f79a6e04504c
https://doi.org/10.1016/s0960-894x(99)00283-8
https://doi.org/10.1016/s0960-894x(99)00283-8
Publikováno v:
The Journal of Organic Chemistry. 62:6726-6732
We have designed a simple (dimethylsilyl)propionic acid linker for the solid phase synthesis of aryl-containing organic compounds. The linker is cleaved smoothly with trifluoroacetic acid either in solution or in the vapor phase to release the unsubs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69b18786cb0498a3d94b1fc9c0fafcd4
https://doi.org/10.1021/jo9620472
https://doi.org/10.1021/jo9620472
Autor:
Philip L. Smith, Andrew J. Nichols, Tobias Oregon Yellin, Kenneth A. Newlander, Raul R. Calvo, James Samanen, Irene N. Uzinskas, Bondinell William E, Chao-Pin Lee, Michael W. Parker, Dalia R. Jakas
Publikováno v:
Advanced Drug Delivery Reviews. 23:133-142
A series of potent, high affinity GPIIb/IIIa antagonists were evaluated for intestinal permeability in vitro using rabbit intestinal strips mounted in the Ussing Chamber. In this series of compounds, structural modifications were found to impact inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::350bdbddf76768ec56b4c8776c870467
https://doi.org/10.1016/s0169-409x(96)00431-0
https://doi.org/10.1016/s0169-409x(96)00431-0
Autor:
Angela S. Wong, James F. Callahan, William H. Miller, Catherine C.K. Yuan, Raul R. Calvo, Janice A. Vasko-Moser, Thomas W. Ku, Richard E. Valocik, Dennis T. Takata, Richard M. Keenan, Drake S. Eggleston, Michael F. Parker, Southall Linda Sue, S M Hwang, Paul F. Koster, William F. Huffman, Tobias Oregon Yellin, Chet Kwon, Irene N. Uzinskas, Bondinell William E, Fadia E. Ali, Dalia R. Jakas, Andrew J. Nichols, James Samanen, R. Curtis Haltiwanger, Kenneth A. Newlander
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2481-2486
In an investigation of the contribution of N-1 to the binding, antiaggregatory, and oral activity in 3-oxo-1,4-benzodiazepine-2-acetic acid based GPIIb/IIIa antagonists, a series of 2-benzazepine analogs, wherein N-1 of the 1,4-benzodiazepine nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef79983c86eb17cdad500249ba3114f
https://doi.org/10.1016/0960-894x(96)00432-5
https://doi.org/10.1016/0960-894x(96)00432-5