Zobrazeno 1 - 10
of 363
pro vyhledávání: '"Kenneth A, Howard"'
Autor:
Oana Hangiu, Marta Compte, Anders Dinesen, Rocio Navarro, Antonio Tapia-Galisteo, Ole A. Mandrup, Ainhoa Erce-Llamazares, Rodrigo Lázaro-Gorines, Daniel Nehme-Álvarez, Carmen Domínguez-Alonso, Seandean L. Harwood, Carlos Alfonso, Belen Blanco, Laura Rubio-Pérez, Anaïs Jiménez-Reinoso, Laura Díez-Alonso, Francisco J. Blanco, Laura Sanz, Kenneth A. Howard, Luis Álvarez-Vallina
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104958- (2022)
Summary: Costimulation of tumor-infiltrating T lymphocytes by anti-4-1BB monoclonal antibodies (mAbs) has shown anti-tumor activity in human trials, but can be associated with significant off-tumor toxicities involving FcγR interactions. Here, we in
Externí odkaz:
https://doaj.org/article/c486f101097e4624bed914bc95a337c3
Autor:
Ole A. Mandrup, Sui Ching Ong, Simon Lykkemark, Anders Dinesen, Imke Rudnik-Jansen, Niels Frederik Dagnæs-Hansen, Jan Terje Andersen, Luis Alvarez-Vallina, Kenneth A. Howard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Mandrup et al. describe a panel of recombinant albumin fusions, engineered with different affinities to the human neonatal Fc receptor to program the half-life extension of a bispecific (EGFR/CD3) T-cell engager. They show that this approach generate
Externí odkaz:
https://doaj.org/article/8e9de18872a44db2b4a88a0afeac0789
Autor:
Elisabeth Fuchs, Imke Rudnik-Jansen, Anders Dinesen, Denis Selnihhin, Ole Aalund Mandrup, Kader Thiam, Jørgen Kjems, Finn Skou Pedersen, Kenneth A. Howard
Publikováno v:
Fuchs, E, Rudnik-Jansen, I, Dinesen, A, Selnihhin, D, Mandrup, O A, Thiam, K, Kjems, J, Pedersen, F S & Howard, K A 2022, ' An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension ', Acta Biomaterialia, vol. 153, pp. 411-418 . https://doi.org/10.1016/j.actbio.2022.09.048
Fuchs, E, Rudnik-Jansen, I, Dinesen, A, Selnihhin, D, Mandrup, O A, Thiam, K, Kjems, J, Pedersen, F S & Howard, K A 2022, ' An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension ', Acta Biomaterialia . https://doi.org/10.1016/j.actbio.2022.09.048
Fuchs, E, Rudnik-Jansen, I, Dinesen, A, Selnihhin, D, Mandrup, O A, Thiam, K, Kjems, J, Pedersen, F S & Howard, K A 2022, ' An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension ', Acta Biomaterialia . https://doi.org/10.1016/j.actbio.2022.09.048
The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutants and breakthrough infections despite available coronavirus disease 2019 (COVID-19) vaccines calls for antiviral therapeutics. The application of soluble angioten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae37760440459ab869708ad2e060897
https://doi.org/10.1016/j.actbio.2022.09.048
https://doi.org/10.1016/j.actbio.2022.09.048
Autor:
Matthias Kuhlmann, Jonas B.R. Hamming, Anders Voldum, Georgia Tsakiridou, Maja T. Larsen, Julie S. Schmøkel, Emil Sohn, Konrad Bienk, David Schaffert, Esben S. Sørensen, Jesper Wengel, Daniel M. Dupont, Kenneth A. Howard
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 284-293 (2017)
The long blood circulatory property of human serum albumin, due to engagement with the cellular recycling neonatal Fc receptor (FcRn), is an attractive drug half-life extension enabling technology. This work describes a novel site-specific albumin do
Externí odkaz:
https://doaj.org/article/51d4e0deff5046be96587b3e4baa4f58
Publikováno v:
Artificial Intelligence for the Earth Systems. 2
The Multi-Radar Multi-Sensor (MRMS) system produces a suite of hydrometeorological products that are widely used for applications such as flash flood warning operations, water resource management, and climatological studies. The MRMS radar-based quan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a15b6a76cb8e891d74f682d0fa835843
https://doi.org/10.1175/aies-d-22-0053.1
https://doi.org/10.1175/aies-d-22-0053.1
Autor:
Torben Falck Ørntoft, Lars Dyrskjøt, Kenneth A. Howard, Michael Borre, Dan Theodorescu, Martin Beck, Jakob S. Pedersen, Jørgen B. Jensen, Jens P. Morth, Iver Nordentoft, Erik I. Christensen, Niels Fristrup, Khan H. Bui, Mads H. Rasmussen, Frederik Dagnaes-Hansen, Philippe Lamy, An Hendrix, Bjarke Primdal-Bengtson, Jesper B. Bramsen, Anders T. Boysen, Jens R. Laurberg, Dennis K. Jeppesen, Marie Stampe Ostenfeld
Lists of A)Quantitative mass spectrometry results of RNA-binding proteins in exosomes, B) Selected miRNAs for further analysis, and C) Downregulated mRNA transcripts (selected) upon RAB27B knockdown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0201e60ae53e47956a1b0504f767830e
https://doi.org/10.1158/0008-5472.22402931
https://doi.org/10.1158/0008-5472.22402931
Autor:
Torben Falck Ørntoft, Lars Dyrskjøt, Kenneth A. Howard, Michael Borre, Dan Theodorescu, Martin Beck, Jakob S. Pedersen, Jørgen B. Jensen, Jens P. Morth, Iver Nordentoft, Erik I. Christensen, Niels Fristrup, Khan H. Bui, Mads H. Rasmussen, Frederik Dagnaes-Hansen, Philippe Lamy, An Hendrix, Bjarke Primdal-Bengtson, Jesper B. Bramsen, Anders T. Boysen, Jens R. Laurberg, Dennis K. Jeppesen, Marie Stampe Ostenfeld
NTA analysis, STR analysis, Pearson correlation values of miRNA expression in exosomes, correlation of miRNA and mRNA target abundance in cells vs. exosomes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83463fce8feecd35c816ca51c4b5ab83
https://doi.org/10.1158/0008-5472.22402949
https://doi.org/10.1158/0008-5472.22402949
Autor:
Torben Falck Ørntoft, Lars Dyrskjøt, Kenneth A. Howard, Michael Borre, Dan Theodorescu, Martin Beck, Jakob S. Pedersen, Jørgen B. Jensen, Jens P. Morth, Iver Nordentoft, Erik I. Christensen, Niels Fristrup, Khan H. Bui, Mads H. Rasmussen, Frederik Dagnaes-Hansen, Philippe Lamy, An Hendrix, Bjarke Primdal-Bengtson, Jesper B. Bramsen, Anders T. Boysen, Jens R. Laurberg, Dennis K. Jeppesen, Marie Stampe Ostenfeld
Supplementary materials&methods and figure legends for supplementary figures and tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3540f2026fafb2411c1f321a74746054
https://doi.org/10.1158/0008-5472.22402928
https://doi.org/10.1158/0008-5472.22402928
Autor:
Torben Falck Ørntoft, Lars Dyrskjøt, Kenneth A. Howard, Michael Borre, Dan Theodorescu, Martin Beck, Jakob S. Pedersen, Jørgen B. Jensen, Jens P. Morth, Iver Nordentoft, Erik I. Christensen, Niels Fristrup, Khan H. Bui, Mads H. Rasmussen, Frederik Dagnaes-Hansen, Philippe Lamy, An Hendrix, Bjarke Primdal-Bengtson, Jesper B. Bramsen, Anders T. Boysen, Jens R. Laurberg, Dennis K. Jeppesen, Marie Stampe Ostenfeld
Analysis of RAB27A and RAB27B expression and genomic alterations in clinical samples. Effect of Rab27b knockdown on cell morphology and long-term growth kinetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464eaee8b37c470383ee7ee359b36d8b
https://doi.org/10.1158/0008-5472.22402943.v1
https://doi.org/10.1158/0008-5472.22402943.v1
Autor:
Torben Falck Ørntoft, Lars Dyrskjøt, Kenneth A. Howard, Michael Borre, Dan Theodorescu, Martin Beck, Jakob S. Pedersen, Jørgen B. Jensen, Jens P. Morth, Iver Nordentoft, Erik I. Christensen, Niels Fristrup, Khan H. Bui, Mads H. Rasmussen, Frederik Dagnaes-Hansen, Philippe Lamy, An Hendrix, Bjarke Primdal-Bengtson, Jesper B. Bramsen, Anders T. Boysen, Jens R. Laurberg, Dennis K. Jeppesen, Marie Stampe Ostenfeld
Effect of RAB27A, RAB27B, and NSMASE2 inhibition on cellular migration and invasion. Bioinformatic analysis of mRNA target sites, AGO2 immunoprecipitation. Analysis of genomic alterations in the miR23b locus and correlation between expression and met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c01ed1d864b25ea1d92990d140a2fa
https://doi.org/10.1158/0008-5472.22402940
https://doi.org/10.1158/0008-5472.22402940