Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kenneth P. Karey"'
Autor:
James M. Murray, John M. McPherson, Allison Vitsky, Joshua Pacheco, Michael L. Hawes, Anne Marie Thompson, Wei-Lien Chuang, Laura Andrews, Beth L. Thurberg, Kenneth P. Karey, Stephen Wilson
Publikováno v:
Molecular Genetics and Metabolism. 114:217-225
Recombinant human acid sphingomyelinase (rhASM) is being developed as an enzyme replacement therapy for patients with acid sphingomyelinase deficiency (Niemann-Pick disease types A and B), which causes sphingomyelin to accumulate in lysosomes. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b2e8e7b2d94befa29a68cc405a0b65
https://doi.org/10.1016/j.ymgme.2014.07.005
https://doi.org/10.1016/j.ymgme.2014.07.005
Autor:
Francis Poulin, Victor R. Cairns, Jin Zhang, Jose Sancho, Christine Demaria, Juanita Campos-Rivera, Scott Estes, Ping Liu, Kenneth P. Karey
Publikováno v:
Biotechnology and Bioengineering. 108:2611-2622
Here we describe a method that couples flow cytometric detection with the attenuated translation of a reporter protein to enable efficient selection of CHO clones producing high levels of recombinant proteins. In this system, a small cell surface rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699975d522d4ef3714aef515ac53a848
https://doi.org/10.1002/bit.23219
https://doi.org/10.1002/bit.23219
Autor:
John M. McPherson, Anne Marie D’Angona, Robin J. Ziegler, Beth L. Thurberg, Seng H. Cheng, Laura Andrews, Christine M. Barbon, Edward H. Schuchman, Claire Brown, Kenneth P. Karey
Publikováno v:
Molecular Genetics and Metabolism. 97:35-42
Systemic administration of recombinant acid sphingomyelinase (rhASM) into ASM deficient mice (ASMKO) results in hydrolysis of the abnormal storage of sphingomyelin in lysosomes of the liver, spleen and lung. However, the efficiency with which the sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd475140e16892f1bda0177ae0da196d
https://doi.org/10.1016/j.ymgme.2009.01.008
https://doi.org/10.1016/j.ymgme.2009.01.008
Autor:
Seng H. Cheng, Edward H. Schuchman, Jonathan A. Fidler, Christopher M. Treleaven, Marco A. Passini, Kenneth P. Karey, Denise Griffiths, Wendy Yang, Tatyana V. Taksir, Lamya S. Shihabuddin, James Dodge, Jennifer Clarke
Publikováno v:
Experimental Neurology. 215:349-357
Niemann-Pick A (NPA) disease is a lysosomal storage disorder (LSD) caused by a deficiency in acid sphingomyelinase (ASM) activity. Previously, we showed that the storage pathology in the ASM knockout (ASMKO) mouse brain could be corrected by intracer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90be1695519f0d90b468493266c95301
https://doi.org/10.1016/j.expneurol.2008.10.021
https://doi.org/10.1016/j.expneurol.2008.10.021
Autor:
Huawei Qiu, Tim Edmunds, Heather Hughes, Scott Estes, Kenneth P. Karey, Cordula Schwarz, Jennifer Baker-Malcolm, Scott M. Van Patten
Publikováno v:
The Journal of biological chemistry. 278(35)
One form of Niemann-Pick disease is caused by a deficiency in the enzymatic activity of acid sphingomyelinase. During efforts to develop an enzyme replacement therapy based on a recombinant form of human acid sphingomyelinase (rhASM), purified prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb0ef5a1facfef26dd4ebd9c70c498f
https://pubmed.ncbi.nlm.nih.gov/12801930
https://pubmed.ncbi.nlm.nih.gov/12801930
Autor:
Christine T. DeMaria, Victor Cairns, Cordula Schwarz, Jin Zhang, Megan Guerin, Erin Zuena, Scott Estes, Kenneth P. Karey
Publikováno v:
Biotechnology Progress; Apr2007, Vol. 23 Issue 2, p465-472, 8p
Autor:
David Danielpour, Masami Ogasawara, Terry L. Riss, Kenneth P. Karey, David A. Sirbasku, Betty H. Stewart
Publikováno v:
Journal of Tissue Culture Methods. 10:133-150
Serum-free defined media have been developed for assay of the mitogenic effects of growth factors on human MCF-7, human T-47D, and mouse COMMA-D mammary cells as well as for identification of mitogens and inhibitors of GH4C1 rat pituitary tumor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d406554810f0d99bb6eaba34605c3f
https://doi.org/10.1007/bf01404604
https://doi.org/10.1007/bf01404604
Autor:
Kenneth P. Karey, David A. Sirbasku
Publikováno v:
Blood. 74:1093-1100
Platelets contain mitogenic activities for MCF-7 human breast cancer cells when assayed under serum-free chemically defined conditions. Purification from outdated human platelets identified insulinlike growth factor I (IGF-I) as the most potent breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b71979267e108304665aacc22fd9c4
https://doi.org/10.1182/blood.v74.3.1093.1093
https://doi.org/10.1182/blood.v74.3.1093.1093
Publikováno v:
Blood. 74:1084-1092
Human platelet lysates contained potent mitogenic activities for MCF-7 human breast-cancer cells in serum-free-defined media. Because these activities were not replaced by known platelet mitogens, such as platelet-derived growth factor or transformin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1646d745a9504bf0b4865c47608ed8d0
https://doi.org/10.1182/blood.v74.3.1084.1084
https://doi.org/10.1182/blood.v74.3.1084.1084
Publikováno v:
In Vitro Cellular & Developmental Biology. 24:1099-1106
A serum-free clonal density growth assay was developed for the quantification of the biological activity of human recombinant insulin-like growth factor I (IGF-I). The assay measures IGF-I stimulated growth of Balb/c 3T3 cells cultured over 4 d on po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1d03872e21d944e2d5b706bd2e5592
https://doi.org/10.1007/bf02620811
https://doi.org/10.1007/bf02620811