Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kenneth Keavey"'
Autor:
Richard S. Todd, Mark Whittaker, Wayne Thomas, John M. Clements, Sheila Doel, Helen Smith, Daniel Christopher Brookings, Alison J. Thompson, Gilles Pain, Paul Beckett, Stephen P. East, Kenneth Keavey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:59-62
A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3' amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3124655adf092283e47a34533311a1e
https://doi.org/10.1016/j.bmcl.2003.10.013
https://doi.org/10.1016/j.bmcl.2003.10.013
Publikováno v:
Current Medicinal Chemistry -Anti-Infective Agents. 1:239-249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eaa315ee6dec8dae638fa68fe929f18
https://doi.org/10.2174/1568012023354866
https://doi.org/10.2174/1568012023354866
Autor:
Peter W. Seale, Peter John Murray, Andrew B. Holmes, Mark Ladlow, Frédéric Berst, Simon L. Croft, Richard J. Upton, Paul Stead, Albert Andrzej Glaxo Wellcome plc Jaxa-Chamiec, William Clegg, Michael Kranz, Kenneth Keavey, Stephen Taylor, Mark R. J. Elsegood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:773-776
A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd8d1793a0c281c4d686a6ae3e11cd3
https://doi.org/10.1016/s0960-894x(01)00049-x
https://doi.org/10.1016/s0960-894x(01)00049-x
Autor:
Kenneth Keavey, Russell J. Thomas, Thomas McDonagh, Hamelin Estelle, Rory A. J. Curtis, Jonathan Barker, Peter S. DiStefano, Patricia Amouzegh, Jean-François Pons, Wei Tsung Yau, Andrew Napper, Jeffrey Hixon, M. J. Kates, Stephen Jones, Jeffrey O. Saunders, Manuel A. Navia, Adam Flegg
Publikováno v:
Journal of Medicinal Chemistry. 50:1086-1086
High-throughput screening against the human sirtuin SIRT1 led to the discovery of a series of indoles as potent inhibitors that are selective for SIRT1 over other deacetylases and NAD-processing enzymes. The most potent compounds described herein inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688909b83bf7f2eb12f50310167448a1
https://doi.org/10.1021/jm061430o
https://doi.org/10.1021/jm061430o
Autor:
Andrew D. Napper, Jeffrey Hixon, Thomas McDonagh, Kenneth Keavey, Jean-Francois Pons, Jonathan Barker, Wei Tsung Yau, Patricia Amouzegh, Adam Flegg, Estelle Hamelin, Russell J. Thomas, Michael Kates, Stephen Jones, Manuel A. Navia, Jeffrey O. Saunders, Peter S. DiStefano, Rory Curtis:
Publikováno v:
Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 5, p1086-1086, 1p