Výsledky vyhledávání - "Kenneth Kassler-Taub"

Long-Term Treatment with Telotristat Ethyl in Patients with Carcinoid Syndrome Symptoms : Results from the TELEPATH Study

Autor: Staffan Welin, David J. Gross, Lowell Anthony, Phillip Banks, Kenneth Kassler-Taub, Polina Binder, Juan W. Valle, Matthew H. Kulke, Martyn Caplin, Marianne Pavel, Marta Benavent, Emily K. Bergsland, Dieter Hörsch, Kjell Öberg, Pablo Lapuerta

Publikováno v: Neuroendocrinology

[Introduction] Telotristat ethyl is indicated for use in combination with somatostatin analogs (SSAs) to treat carcinoid syndrome (CS) diarrhea uncontrolled by SSAs alone in adults, but long-term safety and efficacy data beyond 48 weeks are needed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb676ada73bc2c84b816431744a94231
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502260

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Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-dose and Multiple-dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants

Autor: Thomas L. Hunt, LuAnn Bundrant, Alan Wilson, Kenneth Kassler-Taub, Chris Warner, Phil Banks, Praveen Tyle, Suma Gopinathan, Suman Wason, Kristi A. Boehm

Publikováno v: Clinical therapeutics. 43(6)

Purpose For neuropathic pain, current therapies do not provide relief for most patients; less than half achieve a 50% pain reduction. Current analgesics have adverse effects. We present 2 Phase I studies of LX9211, a new small-molecule AP2-associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a718db9c0cb48300a58b7740a2bfe9e
https://pubmed.ncbi.nlm.nih.gov/34108079

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Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome

Autor: Emily K. Bergsland, Dieter Hörsch, Kjell Öberg, Martyn Caplin, Thomas M. O'Dorisio, Richard R.P. Warner, Pablo Lapuerta, Matthew H. Kulke, Wenjun Jiang, Lowell Anthony, Joseph S. Dillon, Marianne Pavel, Kenneth Kassler-Taub

Publikováno v: The oncologist, vol 24, iss 8

Background Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience considerable morbidity and mortality; carcinoid syndrome may be associated with shorter survival. Carcinoid syndrome is linked to tumoral secretion of serotonin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b9e4f4686257c371a72776a21848ad
https://pubmed.ncbi.nlm.nih.gov/30651397

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Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial

Autor: Wenjun Jiang, Richard R.P. Warner, Petros Perros, Raj Srirajaskanthan, Lowell Anthony, Rosanna Fleming, Matthew H. Kulke, Dieter Hörsch, Suman Wason, David J. Gross, Douglas Fleming, Martin O. Weickert, Pamela L. Kunz, Rocio Garcia-Carbonero, Marta Benavent, Marianne Pavel, Pablo Lapuerta, Kenneth Kassler-Taub

Publikováno v: Endocrine-Related Cancer
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Telotristat ethyl, a tryptophan hydroxylase inhibitor, was efficacious and well tolerated in the phase 3 TELESTAR study in patients with carcinoid syndrome (CS) experiencing ≥4 bowel movements per day (BMs/day) while on somatostatin analogs (SSAs).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bf32ab23bda5252d3ddf51cce13710
https://pubmed.ncbi.nlm.nih.gov/29330194

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Simulated evaluation of a non-Luer safety connector system for use in neuraxial procedures

Autor: Rudy Onia, Kenneth Kassler-Taub, Valentin Parvu, I. Eshun-Wilson, Y. Wu

Publikováno v: British Journal of Anaesthesia. 108:134-139

Background Spinal syringes, needles, and other devices with connectors that will not also connect with Luer devices could substantially reduce wrong-route drug administration errors. This study aimed to evaluate a newly designed non-Luer safety conne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122711184b2952a81a8063c0d9d2e5e0
https://doi.org/10.1093/bja/aer359

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Long-Term Safety and Antihypertensive Efficacy of Irbesartan: Pooled Results of Five Open-Label Studies

Autor: T. Marbury, Thomas Littlejohn, Kenneth Kassler-Taub, Sg Chrysant, Ravi Saini

Publikováno v: Clinical and Experimental Hypertension. 21:1273-1295

An analysis of 5 multicenter, open-label studies was conducted to evaluate the long-term safety and efficacy of irbesartan in 1,006 patients with seated diastolic blood pressure (SeDBP) 95–110 mm Hg. Irbesartan monotherapy was started at 75 mg and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e824d4e64439d01caf0917b00efb70
https://doi.org/10.3109/10641969909070849

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The Antihypertensive Efficacy of the Combination of Irbesartan and Hydrochlorotfflazide Assessed by 24-Hour Ambulatory Blood Pressure Monitoring

Autor: Kenneth Kassler-Taub, Ravi Saini, Peter R. C. Howe, Pat Phillips

Publikováno v: Clinical and Experimental Hypertension. 21:1373-1396

In a multicenter, double-blind, randomized trial, 178 patients with ambulatory diastolic blood pressure (BP) ⩾ 85 mm Hg and seated diastolic BP (SeDBP) 95–110 mm Hg received either once-daily irbesartan 75 mg/hydrochlorothiazide (HCTZ) 12.5 mg, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dd78b16551d431f6392977fdaa7befa
https://doi.org/10.3109/10641969909070855

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Autor: Alexander M.M. Shephard, Thomas W. Wilson, Matthew R. Weir, Thomas Littlejohn, Kenneth Kassler-Taub, Robert M. Guthrie, James L. Pool, Philip Raskin, James M Wright, Richard A. Reeves, Michael A. Weber

Publikováno v: American Journal of Hypertension. 11:462-470

Two multicenter, double-blind, placebo-controlled, parallel group studies were conducted to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of the angiotensin II receptor (AT1 subtype) antagonist irbesartan. The effect of irbesa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb124d6e494d6601a4f723fe08fb447e
https://doi.org/10.1016/s0895-7061(97)00501-3

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Insulin pen needles: effects of extra-thin wall needle technology on preference, confidence, and other patient ratings

Autor: Kenneth Kassler-Taub, Kunjal Oza, Ronnie Aronson, Michael Gibney, Julie Berube, Laurence J. Hirsch

Publikováno v: Clinical therapeutics. 35(7)

BackgroundPen needles (PNs) are essential for insulin injections using pen devices. PN characteristics affect patients’ injection experience.ObjectiveThe goal of this study was to evaluate the impact of a new extra-thin wall (XTW) PN versus usual P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c42aa0a3b6c9354f7a16e37b7486fe0
https://pubmed.ncbi.nlm.nih.gov/23790553

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A multinational study of the effects of low-dose pravastatin in patients with non-insulin-dependent diabetes mellitus and hypercholesterolemia

Autor: Michael Bergman, Bruce D. Behounek, S. Jeffrey Markowitz, Mark E. McGovern, Kenneth Kassler-Taub

Publikováno v: Clinical Cardiology. 17:558-562

This multinational, 16-week, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of low-dose pravastatin in 325 patients with non-insulin-dependent diabetes mellitus (NIDDM) and hypercholesterolemia [serum total chole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9ead0c1e5ccda467553c6734001233b
https://doi.org/10.1002/clc.4960171009

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