Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kenneth, Ruterbories"'
Autor:
Yue-Ting Wang, Estelle M Maes, Lance Heinle, Kenneth Ruterbories, Stella Doktor, Mary Larsen, Amanda Olson, Andrew Lee, Cecilia Van Handel, Qin C Ji, Kelly Desino, Gary J Jenkins
Publikováno v:
Bioanalysis. 15:161-176
While bioanalytical outsourcing is widely adopted in the pharmaceutical industry, AbbVie is one of the few large biopharmaceutical companies having an internal bioanalytical unit to support nearly all its drug metabolism and pharmacokinetic studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cc1920e916d06bb8a99047c4a10df06
https://doi.org/10.4155/bio-2023-0012
https://doi.org/10.4155/bio-2023-0012
Autor:
Nita J Patel, Enaksha Wickremsinhe, Yu-Hua Hui, Alexandar Barr, Nicholas Masterson, Kenneth Ruterbories, Jennifer Weller, Jennifer Hanes, Tom Kern, Everett Perkins
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 19, Iss 4 (2016)
Purpose: Current practices applied to mouse pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles. The purpose of this work was to evaluate and optimize blood micros
Externí odkaz:
https://doaj.org/article/db21fa830dc445b49911f3b6363578ad
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 190
When using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) to quantify In Vivo samples, an internal standard (ISTD) is key in correcting for variability within the sample extraction process and injection volume. Just as important is the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa42e508b9527a83c496fa870b4dc1a6
https://pubmed.ncbi.nlm.nih.gov/32877849
https://pubmed.ncbi.nlm.nih.gov/32877849
Publikováno v:
Journal of chromatography. A. 1606
Three different components that impact carryover in a liquid chromatography-tandem mass spectrometry (LC–MS/MS) method were evaluated to establish baseline conditions for analyzing in vivo samples for twelve monophosphate prodrug compounds and thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe6bed4ad945d86c804c2adb2c4dc2a
https://pubmed.ncbi.nlm.nih.gov/31395357
https://pubmed.ncbi.nlm.nih.gov/31395357
Autor:
Ellen A, Cannady, Aktham, Aburub, Chris, Ward, Chris, Hinds, Boris, Czeskis, Kenneth, Ruterbories, Jeffrey G, Suico, Jane, Royalty, Demetrio, Ortega, Brian W, Pack, Syeda L, Begum, William F, Annes, Qun, Lin, David S, Small
Publikováno v:
Journal of Labelled Compounds & Radiopharmaceuticals
This open-label, single-period study in healthy subjects estimated evacetrapib absolute bioavailability following simultaneous administration of a 130-mg evacetrapib oral dose and 4-h intravenous (IV) infusion of 175 µg [(13) C8 ]-evacetrapib as a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf5d55a4ae511ec743088377372ccfbe
https://pubmed.ncbi.nlm.nih.gov/26639670
https://pubmed.ncbi.nlm.nih.gov/26639670
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 810(2)
A sensitive and selective LC-MS-MS method for the isolation and quantification of alpha-methyltyrosine (AMT) from human plasma is described. The method employs a simple protein precipitation using zinc sulfate and sodium hydroxide. This precipitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::217291b429e8976689b84693d1c37123
https://pubmed.ncbi.nlm.nih.gov/15380719
https://pubmed.ncbi.nlm.nih.gov/15380719
Autor:
Andrew, Williams J, J, Ring Barbara, E, Cantrell Varon, R, Jones David, James, Eckstein, Kenneth, Ruterbories, A, Hamman Mitchell, D, Hall Stephen, A, Wrighton Steven
Publikováno v:
Drug Metabolism and Disposition; August 2002, Vol. 30 Issue: 8 p883-91, 9p