Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Kenneth, MacLeod"'
Autor:
John C. Dawson, Alison Munro, Kenneth Macleod, Morwenna Muir, Paul Timpson, Robert J. Williams, Margaret Frame, Valerie G. Brunton, Neil O. Carragher
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1072-1090 (2022)
A more comprehensive understanding of how cells respond to drug intervention, the likely immediate signalling responses and how resistance may develop within different microenvironments will help inform treatment regimes. The nonreceptor tyrosine kin
Externí odkaz:
https://doaj.org/article/fab8f61f00ef4132b7b597f9dca6a022
Autor:
Priya Sriskandarajah, Alexis De Haven Brandon, Kenneth MacLeod, Neil O. Carragher, Vladimir Kirkin, Martin Kaiser, Steven R. Whittaker
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Multiple myeloma (MM) remains incurable despite recent therapeutic advances. RAS mutations are frequently associated with relapsed/refractory disease. Efforts to target the mitogen-activated protein kinase (MAPK) pathway with the
Externí odkaz:
https://doaj.org/article/87d98533f87749f780cf3deed309028f
Autor:
Ashley Whittington, Ankur Gupta-Wright, Colin Kenneth Macleod, Sarah Ann Filson, Tumena Corrah, Victoria Parris, Miriam Harris, Rachel Tennant, Nidhi Vaid, Junko Takata, Sai Duraisingham, Nemi Gandy, Harmeet Chana, Alastair McGregor, Padmasayee Papineni
Publikováno v:
BMJ Open, Vol 11, Iss 2 (2021)
Objective To describe the characteristics and outcomes of patients with a clinical diagnosis of COVID-19 and false-negative SARS-CoV-2 reverse transcription-PCR (RT-PCR), and develop and internally validate a diagnostic risk score to predict risk of
Externí odkaz:
https://doaj.org/article/b7ddea63897e4016939acfc4d5cba503
Autor:
Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea, Liza Berrout, Cristina Ivan, Mihaela Lorger, John Boyle, Chris Peers, Stephen Muench, Jacobo Elies Gomez, Xin Hu, Carolyn Hurst, Thomas Hall, Sujanitha Umamaheswaran, Laura Wesley, Mihai Gagea, Michael Shires, Iain Manfield, Margaret A. Knowles, Simon Davies, Klaus Suhling, Yurema Teijeiro Gonzalez, Neil Carragher, Kenneth Macleod, N. Joan Abbott, George A. Calin, Nikita Gamper, Peter M. Zygmunt, Zahra Timsah
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the dow
Externí odkaz:
https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb5965
Akademický článek
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Autor:
C. Roland Wolf, Colin J. Henderson, Lesley A. McLaughlin, Jeffrey T.–J. Huang, De Lin, A. Kenneth MacLeod
Supplementary Table 1: MRM parameters for osimertinib, metabolites and internal standard. Supplementary Table 2. Correlation coefficients for formation of osimertinib metabolites. Supplementary Table 3. Metabolic phenotyping of osimertinib in pooled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2950936f04be3c883cf87f0289c278
https://doi.org/10.1158/1078-0432.22469784.v1
https://doi.org/10.1158/1078-0432.22469784.v1
Autor:
C. Roland Wolf, Colin J. Henderson, Lesley A. McLaughlin, Jeffrey T.–J. Huang, De Lin, A. Kenneth MacLeod
Purpose: Osimertinib is a third-generation inhibitor of the epidermal growth factor receptor used in treatment of non–small cell lung cancer. A full understanding of its disposition and capacity for interaction with other medications will facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de38d1349080112b5823ed687534a03
https://doi.org/10.1158/1078-0432.c.6527346.v1
https://doi.org/10.1158/1078-0432.c.6527346.v1
Spearman's rank correlation of OH-vemurafenib formation with probe substrate activities in a panel of HLM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a6f6fca21aeda5adae2f705bc1b3eb
https://doi.org/10.1158/0008-5472.22405488
https://doi.org/10.1158/0008-5472.22405488
Legend for Supplementary Tables S1-S7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e2a3532b12194e239f6eb921f6e8e2
https://doi.org/10.1158/0008-5472.22405494.v1
https://doi.org/10.1158/0008-5472.22405494.v1
Publikováno v:
BMJ (Clinical research ed.). 379