TP53 drives invasion through expression of its Δ133p53β variant

Autor: Gilles Gadea, Nikola Arsic, Kenneth Fernandes, Alexandra Diot, Sébastien M Joruiz, Samer Abdallah, Valerie Meuray, Stéphanie Vinot, Christelle Anguille, Judit Remenyi, Marie P Khoury, Philip R Quinlan, Colin A Purdie, Lee B Jordan, Frances V Fuller-Pace, Marion de Toledo, Maïlys Cren, Alastair M Thompson, Jean-Christophe Bourdon, Pierre Roux

Publikováno v: eLife, Vol 5 (2016)

TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, base

Externí odkaz: https://doaj.org/article/f581c63f2c83491e9dc7660202f2310e

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Autor: Lydia A, Hepburn, Angela, McHugh, Kenneth, Fernandes, Garry, Boag, Charlotte M, Proby, Irene M, Leigh, Mark K, Saville

Publikováno v: Oncotarget

We show that suppression of the spliceosome has potential for the treatment of cutaneous squamous cell carcinoma (cSCC). The small-molecule inhibitors of the spliceosome at the most advanced stage of development target the splicing factor SF3B1/SF3b1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94da23a18ea0571cc08f705e5ad513c7
https://pubmed.ncbi.nlm.nih.gov/29796170

TP53 drives invasion through expression of its Δ133p53β variant

Autor: Frances V. Fuller-Pace, Samer Abdallah, Pierre Roux, Christelle Anguille, Marie P. Khoury, Alexandra Diot, Nikola Arsic, Valerie Meuray, Colin A. Purdie, Philip R. Quinlan, Judit Remenyi, St�phanie Vinot, Marion de Toledo, S�bastien M. Joruiz, Ma�lys Cren, Gilles Gadea, Lee B. Jordan, Kenneth Fernandes, Alastair M. Thompson, Jean-Christophe Bourdon

Publikováno v: eLife
eLife, eLife Sciences Publication, 2016, 5, 〈10.7554/eLife.14734〉
eLife, Vol 5 (2016)
eLife, eLife Sciences Publication, 2016, 5, pp.e14734. ⟨10.7554/eLife.14734⟩
eLife, 2016, 5, pp.e14734. ⟨10.7554/eLife.14734⟩

TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6e5e3665203f26a5977193bbf1fdd8
http://hal.univ-reunion.fr/hal-01703040

Tumor Susceptibility and Apoptosis Defect in a Mouse Strain Expressing a Human p53 Transgene

Autor: Crissy Dudgeon, Jean-Christophe Bourdon, David P. Lane, Alexandra Diot, Calvina Kek, Kenneth Fernandes, Shin'ichi Saito, Albert J. Fornace, Ettore Appella, Oleg N. Demidov, Dmitry V. Bulavin

Publikováno v: Cancer Research. 66:2928-2936

Activation of apoptosis is believed to be critical for the role of p53 as a tumor suppressor. Here, we report a new mouse strain carrying a human p53 transgene in the mouse p53-null background. Expression of human p53 in these mice was comparable wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e604ec1da6b5659f5c477786d691a6
https://doi.org/10.1158/0008-5472.can-05-2063

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

Autor: Jean-Christophe Bourdon, David P. Lane, Kenneth Fernandes, J. Renzing, P.L. Robertson

Publikováno v: The Journal of Cell Biology
Scopus-Elsevier

p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8586822dbc2dcb0a05d90dc6a8baad
http://europepmc.org/articles/PMC2173124