Zobrazeno 1 - 10
of 3 101
pro vyhledávání: '"Kenner C"'
Publikováno v:
Molecules, Vol 29, Iss 14, p 3331 (2024)
We recently developed a series of nalfurafine analogs (TK10, TK33, and TK35) that may serve as non-addictive candidate analgesics. These compounds are mixed-action agonists at the kappa and delta opioid receptors (KOR and DOR, respectively) and produ
Externí odkaz:
https://doaj.org/article/3bd22c861a0e4555aaa74314112260cd
Autor:
Hudson G. Roth, Madhurima Das, Agnieszka Sulima, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 29, Iss 9, p 1926 (2024)
The synthesis of stereochemically pure oximes, amines, saturated and unsaturated cyanomethyl compounds, and methylaminomethyl compounds at the C9 position in 3-hydroxy-N-phenethyl-5-phenylmorphans provided μ-opioid receptor (MOR) agonists with varie
Externí odkaz:
https://doaj.org/article/ffafaa3d32ea40d5bd3043c657d40a47
Autor:
Robert W. Seaman, Kariann Lamon, Nicholas Whitton, Brian Latimer, Agnieszka Sulima, Kenner C. Rice, Kevin S. Murnane, Gregory T. Collins
Publikováno v:
Brain Sciences, Vol 14, Iss 3, p 258 (2024)
Recent data suggest that 3,4-methylenedioxypyrovalerone (MDPV) has neurotoxic effects; however, the cognitive and neurochemical consequences of MDPV self-administration remain largely unexplored. Furthermore, despite the fact that drug preparations t
Externí odkaz:
https://doaj.org/article/e97d2a6a879949308a5852f1a660f32f
Autor:
Edna J. Santos, Nima Nassehi, Eric W. Bow, Dana R. Chambers, Eugene S. Gutman, Arthur E. Jacobson, Joshua A. Lutz, Samuel A. Marsh, Kenner C. Rice, Agnieszka Sulima, Dana E. Selley, S. Stevens Negus
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 4, Pp n/a-n/a (2023)
Abstract Low‐efficacy mu‐opioid receptor (MOR) agonists represent promising therapeutics, but existing compounds (e.g., buprenorphine, nalbuphine) span a limited range of low MOR efficacies and have poor MOR selectivity. Accordingly, new and sele
Externí odkaz:
https://doaj.org/article/3416c03aeec64d3f8a90e94380e1ee04
Autor:
Madhurima Das, George W. Ward, Agnieszka Sulima, Dan Luo, Thomas Edward Prisinzano, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 28, Iss 23, p 7709 (2023)
(−)-5,9-Dimethyl-6,7-benzomorphan (normetazocine) derivatives with a para-OH or ortho-F substituent in the aromatic ring of the N-phenethyl moiety were synthesized and found to have subnanomolar potency at MOR, and both were fully efficacious in vi
Externí odkaz:
https://doaj.org/article/9bbb663c8248404c9ee45202cb61671a
Publikováno v:
Brain Sciences, Vol 13, Iss 9, p 1294 (2023)
Background: As individual synthetic cathinones become scheduled and regulated by the Drug Enforcement Administration (DEA), new ones regularly are produced and distributed. One such compound is eutylone, a novel third-generation synthetic cathinone w
Externí odkaz:
https://doaj.org/article/c4ec772c09e746b9a4117410ce1fa241
Autor:
Andrew J. Kwilasz, Madison A. Clements, Tracey A. Larson, Kevin M. Harris, Scott T. Litwiler, Brodie J. Woodall, Laurel S. Todd, Anouk E. W. Schrama, Eric H. Mitten, Steven F. Maier, Anne-Marie Van Dam, Kenner C. Rice, Linda R. Watkins
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Up to 92% of patients suffering from multiple sclerosis (MS) experience pain, most without adequate treatment, and many report pain long before motor symptoms associated with MS diagnosis. In the most commonly studied rodent model of MS, experimental
Externí odkaz:
https://doaj.org/article/f69561aa0381439c90004b4abc048684
Autor:
Dana R. Chambers, Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 28, Iss 14, p 5411 (2023)
The 5-(3-hydroxy)phenylmorphan structural class of compounds are unlike the classical morphinans, 4,5-epoxymorphinans, and 6,7-benzomorphans, in that they have an equatorially oriented aromatic ring rather than the axial orientation of that ring foun
Externí odkaz:
https://doaj.org/article/1173e73197ae44f09a580ac3675e041b
Autor:
Joshua A. Lutz, Agnieszka Sulima, Eugene S. Gutman, Eric W. Bow, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Carol A. Paronis, Jack Bergman, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 28, Iss 12, p 4795 (2023)
All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists. These compou
Externí odkaz:
https://doaj.org/article/d4aecd3b74884423a75e5b6fc1efb0c0
Publikováno v:
Brain Sciences, Vol 13, Iss 4, p 585 (2023)
Background: Prior work has reported that a drug’s aversive effects (as indexed by taste avoidance conditioning) are attenuated when the pre-exposure and conditioning drugs are the same or different. The latter, otherwise known as cross-drug pre-exp
Externí odkaz:
https://doaj.org/article/ee2d6054e2674f5187dd443f0577b110