Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kennedy Poro"'
Autor:
Christie M. Penniman, Pablo A. Suarez Beltran, Gourav Bhardwaj, Taylor L. Junck, Jayashree Jena, Kennedy Poro, Michael F. Hirshman, Laurie J. Goodyear, Brian T. O'Neill
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 203-220 (2019)
Objective: Gender influences obesity-related complications, including diabetes. Females are more protected from insulin resistance after diet-induced obesity, which may be related to fat accumulation and muscle insulin sensitivity. FoxOs regulate mus
Externí odkaz:
https://doaj.org/article/93d1c05e592b4da0ba81a670a72c2b86
Autor:
Kennedy Poro, Pablo A. Suarez Beltran, Jayashree Jena, Gourav Bhardwaj, Michael F. Hirshman, Brian T. O’Neill, Christie M. Penniman, Laurie J. Goodyear, Taylor L. Junck
Publikováno v:
Molecular Metabolism, Vol 30, Iss, Pp 203-220 (2019)
Molecular Metabolism
Molecular Metabolism
Objective: Gender influences obesity-related complications, including diabetes. Females are more protected from insulin resistance after diet-induced obesity, which may be related to fat accumulation and muscle insulin sensitivity. FoxOs regulate mus
Autor:
Vitor A. Lira, Gourav Bhardwaj, E. Dale Abel, William I. Sivitz, Kennedy Poro, Antentor Othrell Hinton, Brian T. O’Neill, Taylor L. Junck, Jayashree Jena, Pablo E. Morales, Jordan D. Fuqua, Rhonda Souvenir, Pablo A. Suarez Beltran, Collin M. Foster, Roberto Bravo-Sagua, Christie M. Penniman
Publikováno v:
J Clin Invest
Decreased skeletal muscle strength and mitochondrial dysfunction are characteristic of diabetes. The actions of insulin and IGF-1 through the insulin receptor (IR) and IGF-1 receptor (IGF1R) maintain muscle mass via suppression of forkhead box O (Fox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8998d4c67081f0a14b7f720715e34025
https://europepmc.org/articles/PMC8439595/
https://europepmc.org/articles/PMC8439595/
Autor:
Kennedy Poro, Hui Pan, Jonathan M. Dreyfuss, Katherine A. Klaus, Brian T. O’Neill, C. Ronald Kahn, Gourav Bhardwaj, Mengyao E. Li, K. Sreekumaran Nair, Megan T. Krumpoch, Pablo A. Suarez Beltran, Christie M. Penniman
Publikováno v:
Diabetes
Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle strength, contributing to disease-related morbidity. FoxO transcription factors are suppressed by insulin and thus are key mediators of insulin action. To st
Autor:
Taylor L. Junck, Gourav Bhardwaj, Brian T. O’Neill, Kennedy Poro, Rhonda Souvenir, Pablo E. Morales, Jordan D. Fuqua, Collin M. Foster, Roberto Bravo-Sagua, Christie M. Penniman, Pablo A. Suarez Beltran, Antentor Othrell Hinton, Jayashree Jena, Vitor A. Lira, Evan Dale Abel
Publikováno v:
Diabetes. 69
Diabetes is associated with decreased muscle strength and mitochondrial metabolism which can lead to disability. Recently, we reported that insulin receptor (IR) and IGF-1 receptor (IGF1R) prevent muscle atrophy via suppression of FoxOs, but how FoxO