Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-$^{13}$C] Dehydroascorbic Acid Reduction Using $^{13}$C Magnetic Resonance Spectroscopy

Autor: Timm, KN, Hu, D-E, Williams, M, Wright, AJ, Kettunen, MI, Kennedy, BWC, Larkin, TJ, Dzien, P, Marco-Rius, I, Bohndiek, SE, Brindle, KM

Rapid cancer cell proliferation promotes the production of reducing equivalents, which counteract the effects of relatively high levels of reactive oxygen species (ROS). ROS levels increase in response to chemotherapy and cell death while an increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a1cfa888936e4a898f9edc6a62e4aeb

AICAR confers prophylactic cardioprotection in doxorubicin-induced heart failure in rats.

Autor: Choksey A; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Carter RD; Department of Physiology Anatomy and Genetics, University of Oxford, UK; Doctoral Training Centre, University of Oxford, Keble Road, Oxford, OX1 3NP, UK., Thackray BD; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Ball V; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Kennedy BWC; Department of Physiology Anatomy and Genetics, University of Oxford, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK., Ha LHT; Department of Pharmacology, University of Oxford, UK., Sharma E; Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7BN, UK., Broxholme J; Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7BN, UK., Castro-Guarda M; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, UK., Heather LC; Department of Physiology Anatomy and Genetics, University of Oxford, UK., Tyler DJ; Department of Physiology Anatomy and Genetics, University of Oxford, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK., Timm KN; Department of Physiology Anatomy and Genetics, University of Oxford, UK; Department of Pharmacology, University of Oxford, UK. Electronic address: kerstin.timm@pharm.ox.ac.uk.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Jun; Vol. 191, pp. 12-22. Date of Electronic Publication: 2024 Apr 21.

Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.

Autor: Timm KN; From the Department of Biochemistry, University of Cambridge, Cambridge CB2 0RE, United Kingdom; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Hu DE; From the Department of Biochemistry, University of Cambridge, Cambridge CB2 0RE, United Kingdom; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Williams M; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Wright AJ; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Kettunen MI; From the Department of Biochemistry, University of Cambridge, Cambridge CB2 0RE, United Kingdom; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Kennedy BWC; From the Department of Biochemistry, University of Cambridge, Cambridge CB2 0RE, United Kingdom; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Larkin TJ; From the Department of Biochemistry, University of Cambridge, Cambridge CB2 0RE, United Kingdom; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Dzien P; From the Department of Biochemistry, University of Cambridge, Cambridge CB2 0RE, United Kingdom; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Marco-Rius I; From the Department of Biochemistry, University of Cambridge, Cambridge CB2 0RE, United Kingdom; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Bohndiek SE; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom; the Department of Physics, University of Cambridge, Cambridge CB2 0RE, United Kingdom., Brindle KM; From the Department of Biochemistry, University of Cambridge, Cambridge CB2 0RE, United Kingdom; the Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom. Electronic address: kmb1001@cam.ac.uk.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2017 Feb 03; Vol. 292 (5), pp. 1737-1748. Date of Electronic Publication: 2016 Dec 19.