Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Kenna R. Mills-Shaw"'
Autor:
Amber Johnson, Patrick Kwok-Shing Ng, Michael Kahle, Julia Castillo, Bianca Amador, Yujia Wang, Jia Zeng, Vijaykumar Holla, Thuy Vu, Fei Su, Sun-Hee Kim, Tara Conway, Xianli Jiang, Ken Chen, Kenna R. Mills Shaw, Timothy A. Yap, Jordi Rodon, Gordon B. Mills, Funda Meric-Bernstam
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-10 (2023)
Abstract Genomically-informed therapy requires consideration of the functional impact of genomic alterations on protein expression and/or function. However, a substantial number of variants are of unknown significance (VUS). The MD Anderson Precision
Externí odkaz:
https://doaj.org/article/ea14c4c6b3b5424a934c054faa736889
Autor:
Theodore Sakellaropoulos, Konstantinos Vougas, Sonali Narang, Filippos Koinis, Athanassios Kotsinas, Alexander Polyzos, Tyler J. Moss, Sarina Piha-Paul, Hua Zhou, Eleni Kardala, Eleni Damianidou, Leonidas G. Alexopoulos, Iannis Aifantis, Paul A. Townsend, Mihalis I. Panayiotidis, Petros Sfikakis, Jiri Bartek, Rebecca C. Fitzgerald, Dimitris Thanos, Kenna R. Mills Shaw, Russell Petty, Aristotelis Tsirigos, Vassilis G. Gorgoulis
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3367-3373.e4 (2019)
Summary: A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a personalized basis. Using a pharmacogenomics database of 1,001 cancer cell lines, we trained deep neural networks for prediction of drug response
Externí odkaz:
https://doaj.org/article/2f093439d55c431e845ff5db7f56e938
Autor:
Hongxin Zhang, Ahmet Zehir, Emily Yu, Thomas V. Yu, Celeste Yu, Stuart Watt, Chetna Wathoo, Lucy L. Wang, Emile E. Voest, Carl Virtanen, Victor E. Velculescu, Harm van Tinteren, Tony van de Velde, Laura J. Van 'T Veer, Eliezer M. Van Allen, Stacy B. Thomas, Jelle J. ten Hoeve, Barry S. Taylor, Shawn M. Sweeney, Thomas P. Stricker, Natalie H. Stickle, Parin Sripakdeevong, Jean Charles Soria, Gabe S. Sonke, David B. Solit, Lillian L. Siu, Priyanka Shivdasani, Kenna R Mills Shaw, Nikolaus Schultz, Deborah Schrag, Charles L. Sawyers, Mark J. Routbort, Barrett J. Rollins, Brendan Reardon, Trevor J. Pugh, Ben Ho Park, John A. Orechia, Larsson Omberg, Petra M. Nederlof, Nathanael D. Moore, Gordon Mills, Clinton Miller, Christine M. Micheel, Funda Meric-Bernstam, Gerrit A. Meijer, David S. Maxwell, Ian Maurer, Laura E. MacConaill, Zhibin Lu, David Liu, James Lindsay, Neal I. Lindeman, Mia A. Levy, Eva M. Lepisto, Michele L. LeNoue-Newton, Céline Lefebvre, Marc Ladanyi, Ritika Kundra, Priti Kumari, Walter Kinyua, Cyriac Kandoth, Suzanne Kamel-Reid, David M. Hyman, Jan Hudeček, Hugo Horlings, Stephanie Hintzen, Zachary J. Heins, Justin Guinney, Benjamin E. Gross, Christopher D. Gocke, Stu Gardos, Francisco Garcia, Jianjiong Gao, P. Andrew Futreal, Matthew D. Ducar, Raymond N. DuBois, Semih Dogan, Catherine Del Vecchio Fitz, Nancy E. Davidson, Kristen K. Dang, Debyani Chakravarty, Ethan Cerami, Fabien Calvo, Mariska Bierkens, Michael F. Berger, Philippe L. Bedard, José Baselga, Alexander S. Baras, Monica Arnedos, Fabrice André
Table S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ccfc80c9880f31623d416c3743e207
https://doi.org/10.1158/2159-8290.22531885
https://doi.org/10.1158/2159-8290.22531885
Autor:
John F. de Groot, Shiao-Pei Weathers, W.K. Alfred Yung, Gordon B. Mills, Roel G. Verhaak, Ken Chen, Gregory N. Fuller, Funda Meric-Bernstam, Kenna R. Mills Shaw, Agda Karina Eterovic, Fang Wang, Xiaojing Wang, Wei Wei, Kristin Alfaro-Munoz, Siyuan Zheng
Univariate and multivariate survival analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b8473b6693fae6d22ff38138ad539e
https://doi.org/10.1158/1535-7163.22504552
https://doi.org/10.1158/1535-7163.22504552
Autor:
Hongxin Zhang, Ahmet Zehir, Emily Yu, Thomas V. Yu, Celeste Yu, Stuart Watt, Chetna Wathoo, Lucy L. Wang, Emile E. Voest, Carl Virtanen, Victor E. Velculescu, Harm van Tinteren, Tony van de Velde, Laura J. Van 'T Veer, Eliezer M. Van Allen, Stacy B. Thomas, Jelle J. ten Hoeve, Barry S. Taylor, Shawn M. Sweeney, Thomas P. Stricker, Natalie H. Stickle, Parin Sripakdeevong, Jean Charles Soria, Gabe S. Sonke, David B. Solit, Lillian L. Siu, Priyanka Shivdasani, Kenna R Mills Shaw, Nikolaus Schultz, Deborah Schrag, Charles L. Sawyers, Mark J. Routbort, Barrett J. Rollins, Brendan Reardon, Trevor J. Pugh, Ben Ho Park, John A. Orechia, Larsson Omberg, Petra M. Nederlof, Nathanael D. Moore, Gordon Mills, Clinton Miller, Christine M. Micheel, Funda Meric-Bernstam, Gerrit A. Meijer, David S. Maxwell, Ian Maurer, Laura E. MacConaill, Zhibin Lu, David Liu, James Lindsay, Neal I. Lindeman, Mia A. Levy, Eva M. Lepisto, Michele L. LeNoue-Newton, Céline Lefebvre, Marc Ladanyi, Ritika Kundra, Priti Kumari, Walter Kinyua, Cyriac Kandoth, Suzanne Kamel-Reid, David M. Hyman, Jan Hudeček, Hugo Horlings, Stephanie Hintzen, Zachary J. Heins, Justin Guinney, Benjamin E. Gross, Christopher D. Gocke, Stu Gardos, Francisco Garcia, Jianjiong Gao, P. Andrew Futreal, Matthew D. Ducar, Raymond N. DuBois, Semih Dogan, Catherine Del Vecchio Fitz, Nancy E. Davidson, Kristen K. Dang, Debyani Chakravarty, Ethan Cerami, Fabien Calvo, Mariska Bierkens, Michael F. Berger, Philippe L. Bedard, José Baselga, Alexander S. Baras, Monica Arnedos, Fabrice André
AACR GENIE Data Guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8912da47675cfaab3b60ccb057d7ba8e
https://doi.org/10.1158/2159-8290.22531897.v1
https://doi.org/10.1158/2159-8290.22531897.v1
Autor:
Hongxin Zhang, Ahmet Zehir, Emily Yu, Thomas V. Yu, Celeste Yu, Stuart Watt, Chetna Wathoo, Lucy L. Wang, Emile E. Voest, Carl Virtanen, Victor E. Velculescu, Harm van Tinteren, Tony van de Velde, Laura J. Van 'T Veer, Eliezer M. Van Allen, Stacy B. Thomas, Jelle J. ten Hoeve, Barry S. Taylor, Shawn M. Sweeney, Thomas P. Stricker, Natalie H. Stickle, Parin Sripakdeevong, Jean Charles Soria, Gabe S. Sonke, David B. Solit, Lillian L. Siu, Priyanka Shivdasani, Kenna R Mills Shaw, Nikolaus Schultz, Deborah Schrag, Charles L. Sawyers, Mark J. Routbort, Barrett J. Rollins, Brendan Reardon, Trevor J. Pugh, Ben Ho Park, John A. Orechia, Larsson Omberg, Petra M. Nederlof, Nathanael D. Moore, Gordon Mills, Clinton Miller, Christine M. Micheel, Funda Meric-Bernstam, Gerrit A. Meijer, David S. Maxwell, Ian Maurer, Laura E. MacConaill, Zhibin Lu, David Liu, James Lindsay, Neal I. Lindeman, Mia A. Levy, Eva M. Lepisto, Michele L. LeNoue-Newton, Céline Lefebvre, Marc Ladanyi, Ritika Kundra, Priti Kumari, Walter Kinyua, Cyriac Kandoth, Suzanne Kamel-Reid, David M. Hyman, Jan Hudeček, Hugo Horlings, Stephanie Hintzen, Zachary J. Heins, Justin Guinney, Benjamin E. Gross, Christopher D. Gocke, Stu Gardos, Francisco Garcia, Jianjiong Gao, P. Andrew Futreal, Matthew D. Ducar, Raymond N. DuBois, Semih Dogan, Catherine Del Vecchio Fitz, Nancy E. Davidson, Kristen K. Dang, Debyani Chakravarty, Ethan Cerami, Fabien Calvo, Mariska Bierkens, Michael F. Berger, Philippe L. Bedard, José Baselga, Alexander S. Baras, Monica Arnedos, Fabrice André
Supplemental Methods. Supplemental Table 1: ââ,¬â€¹Genomic Data Characterization by Center. Supplemental Table 2: ââ,¬â€¹Gene Panels Submitted by Each Center. Figure S1: Number of putative germline SNPs per sample, before and after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0898b4b793064fbee55cfdd12d0e9a
https://doi.org/10.1158/2159-8290.22531894.v1
https://doi.org/10.1158/2159-8290.22531894.v1
Autor:
John F. de Groot, Shiao-Pei Weathers, W.K. Alfred Yung, Gordon B. Mills, Roel G. Verhaak, Ken Chen, Gregory N. Fuller, Funda Meric-Bernstam, Kenna R. Mills Shaw, Agda Karina Eterovic, Fang Wang, Xiaojing Wang, Wei Wei, Kristin Alfaro-Munoz, Siyuan Zheng
S1 shows intratumor mutation heterogeneity between two specimens of one tumor. S2 describes mutational load of the patient cohort. S3 shows survival difference based on histology. S4 shows mutational signature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6018bd5dae5deda8860fc1eefe9995e5
https://doi.org/10.1158/1535-7163.22504561
https://doi.org/10.1158/1535-7163.22504561
Autor:
John F. de Groot, Shiao-Pei Weathers, W.K. Alfred Yung, Gordon B. Mills, Roel G. Verhaak, Ken Chen, Gregory N. Fuller, Funda Meric-Bernstam, Kenna R. Mills Shaw, Agda Karina Eterovic, Fang Wang, Xiaojing Wang, Wei Wei, Kristin Alfaro-Munoz, Siyuan Zheng
Malignant gliomas are a group of intracranial cancers associated with disproportionately high mortality and morbidity. Here, we report ultradeep targeted sequencing of a prospective cohort of 237 tumors from 234 patients consisting of both glioblasto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9da58b228b561d02d5462a2a9d9129f
https://doi.org/10.1158/1535-7163.c.6537775.v1
https://doi.org/10.1158/1535-7163.c.6537775.v1
Autor:
Razelle Kurzrock, Sadakatsu Ikeda, Funda Meric-Bernstam, James C. Yao, Robert A. Wolff, Kanwal P.S. Raghav, Abedul Haque, Bhawana George, Kenna R. Mills-Shaw, AmirAli Talasaz, Richard B. Lanman, Kimberly C. Banks, Asif Rashid, Manal M. Hassan, Hesham M. Amin, Jeffrey Morris, Lianchun Xiao, Wei Qiao, Roberto Carmagnani Pestana, Marc Uemura, Reham Abdel-Wahab, Kian H. Lim, Andrea G. Bocobo, Benjamin Tan, Robin K. Kelley, Shiraj Sen, Nora S. Sánchez, Ahmed O. Kaseb
Purpose:Molecular profiling has been used to select patients for targeted therapy and determine prognosis. Noninvasive strategies are critical to hepatocellular carcinoma (HCC) given the challenge of obtaining liver tissue biopsies.Experimental Desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc7bcc4a5c85785aef33cebdc420dad
https://doi.org/10.1158/1078-0432.c.6527795.v1
https://doi.org/10.1158/1078-0432.c.6527795.v1
Autor:
Funda Meric-Bernstam, Richard B. Lanman, Victoria M. Raymond, David R. Fogelman, Siqing Fu, Vivek Subbiah, David S. Hong, Ahmed O. Kaseb, Milind Javle, Senthilkumar Damodaran, Cathy Eng, Kenna R. Mills Shaw, Nora S. Sanchez, Filip Janku, Kenneth R. Hess, Seyed Pairawan
Purpose:Physicians are expected to assess prognosis both for patient counseling and for determining suitability for clinical trials. Increasingly, cell-free circulating tumor DNA (cfDNA) sequencing is being performed for clinical decision making. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee9b38a61be4759a2148759564c81ec
https://doi.org/10.1158/1078-0432.c.6528630.v1
https://doi.org/10.1158/1078-0432.c.6528630.v1