Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kenjiro Tsubota"'
Autor:
John L. Vahle, Joe Dybowski, Michael Graziano, Shigeru Hisada, Jose Lebron, Thomas Nolte, Ronald Steigerwalt, Kenjiro Tsubota, Frank D. Sistare
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Industry representatives on the ICH S1B(R1) Expert Working Group (EWG) worked closely with colleagues from the Drug Regulatory Authorities to develop an addendum to the ICH S1B guideline on carcinogenicity studies that allows for a weight-of-evidence
Externí odkaz:
https://doaj.org/article/053d6740fba4457d80fc51a572935162
Autor:
Vahle, John L., Dybowski, Joe, Graziano, Michael, Shigeru Hisada, Lebron, Jose, Nolte, Thomas, Steigerwalt, Ronald, Kenjiro Tsubota, Sistare, Frank D.
Publikováno v:
Frontiers in Toxicology; 2024, p1-17, 17p
Autor:
Shigeru Hisada1,2 hisada-s@aska-pharma.co.jp, Kenjiro Tsubota1,3 kenjiro.tsubota@astellas.com, Kenji Inoue1,4, Hisaharu Yamada1,5, Takanori Ikeda1,6, Sistare, Frank D.7,8
Publikováno v:
Journal of Toxicologic Pathology. 2022, Vol. 35 Issue 1, p53-73. 21p.
Autor:
Frank D. Sistare, Takanori Ikeda, Shigeru Hisada, Hisaharu Yamada, Kenji Inoue, Kenjiro Tsubota
Publikováno v:
Journal of Toxicologic Pathology. 35:53-73
The pharmacokinetic endpoint of a 25-fold increase in human exposure is one of the specified criteria for high-dose selection for 2-year carcinogenicity studies in rodents according to ICH S1C(R2). However, this criterion is not universally accepted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9659600d7a670d10a8a26b7394849ef
https://doi.org/10.1293/tox.2021-0031
https://doi.org/10.1293/tox.2021-0031
Autor:
Kenjiro Tsubota1 kenjiro.tsubota@astellas.com, Masayuki Kanki1, Takahisa Noto1, Shunji Nakatsuji1, Yuji Oishi1, Masahiro Matsumoto1, Hiroyuki Nakayama2
Publikováno v:
Journal of Toxicological Sciences. Jun2015, Vol. 40 Issue 3, p413-425. 13p.
Autor:
Akira Unami, Masatoshi Yuri, Daisuke Sasaki, Gi Wook Hwang, Kenjiro Tsubota, Masashi Hiramoto, Akira Naganuma, Akira Moriguchi, Hikaru Mitori
Publikováno v:
Fundamental Toxicological Sciences. 4:77-83
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537782db174d4d99ac77fdfdde4f873a
https://doi.org/10.2131/fts.4.77
https://doi.org/10.2131/fts.4.77
Autor:
Hiroshi Arai, Yoshiaki Ohtsu, Kenjiro Tsubota, Jacqueline A. Gibbons, Dhiren R. Thakker, Shohei Otsuka
Publikováno v:
CHROMATOGRAPHY. 36:115-122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0162a3728ede93be34392cbd28e4c94b
https://doi.org/10.15583/jpchrom.2015.029
https://doi.org/10.15583/jpchrom.2015.029
Autor:
Masahiro Matsumoto, Takahisa Noto, Yuji Oishi, Hiroyuki Nakayama, Kenjiro Tsubota, Masayuki Kanki, Shunji Nakatsuji
Publikováno v:
The Journal of Toxicological Sciences. 40:413-425
It is well-known that indomethacin (the cyclooxygenase 1 & 2 inhibitor) and RU486 (or mifepristone, the progesterone receptor antagonist) block follicular rupture in rats. To characterize genetic alterations in unruptured follicles, gene expression p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e79744e4326b88fb987ae4f79b1fd4a
https://doi.org/10.2131/jts.40.413
https://doi.org/10.2131/jts.40.413
Autor:
Yoshimasa Okazaki, Akiko Anagawa, Yuichi Murakami, Kenjiro Tsubota, Yuji Oishi, Mihoko Ono, Masahiro Matsumoto, Shunji Nakatsuji
Publikováno v:
Journal of Toxicologic Pathology
A firm, tan, well-circumscribed mass that measured 25 × 30 × 35 mm was observed in the thoracic cavity of a 53-week-old male Crl:CD(SD) IGS rat. Histologically, the mass was encapsulated by fibrous tissue and contained fibrovascular septae. Tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717c8c0dd20368e769f377ff58a09837
http://europepmc.org/articles/PMC3252043
http://europepmc.org/articles/PMC3252043
Autor:
Katsuhiko Yoshizawa, Shunji Nakatsuji, Yuji Oishi, Masahiro Matsumoto, Yoshimasa Okazaki, Kenjiro Tsubota, Shiro Fujihira
Publikováno v:
Journal of Toxicologic Pathology. 17:211-218
A spontaneous ovarian immature teratoma characterized by the presence of tissue derivatives of endoderm, mesoderm and ectoderm was investigated histopathologically in a 6-week-old juvenile Crj:CD(SD)IGS rat. The various kinds of tissue components obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81dacd85fe5cc5dc44466420499df54a
https://doi.org/10.1293/tox.17.211
https://doi.org/10.1293/tox.17.211