Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Kenjiro Tadagaki"'
Autor:
Renshi Kawakatsu, Kenjiro Tadagaki, Kenta Yamasaki, Yasumichi Kuwahara, Shinichiro Nakada, Tatsushi Yoshida
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Venetoclax is a BH3 mimetic that was recently approved for the treatment of acute myeloid leukemia (AML) treatment. However, the effect of venetoclax on AML remains limited, and a novel strategy is required. Here, we demonstrate for the firs
Externí odkaz:
https://doaj.org/article/4ea9f1df2a824058b5062dbe809d1918
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Venetoclax has been approved recently for treatment of Acute myeloid leukemia (AML). Venetoclax is a BH3-mimetic and induces apoptosis via Bcl-2 inhibition. However, venetoclax’s effect is still restrictive and a novel strategy is needed.
Externí odkaz:
https://doaj.org/article/6c92633f6f8543138884a45123f04d5d
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract High transfection efficiency is the most important point for experiments of DNA and RNA introduction into cells. Decrease of cell viability during the transfection procedure is a crucial issue, resulting in transfection failure. However, the
Externí odkaz:
https://doaj.org/article/4a0c471400274bf5986b51642f0702ab
Autor:
Akifumi Matsumoto, Tatsushi Yoshida, Takahiro Shima, Kenta Yamasaki, Kenjiro Tadagaki, Noriko Kondo, Yasumichi Kuwahara, Dong-Er Zhang, Tsukasa Okuda
Publikováno v:
BBA Advances, Vol 2, Iss , Pp 100047- (2022)
The fusion protein RUNX1-ETO is an oncogenic transcription factor generated by t(8;21) chromosome translocation, which is found in FAB-M2-type acute myeloid leukemia (AML). RUNX1-ETO is known to dysregulate the normal RUNX1 transcriptional network, w
Externí odkaz:
https://doaj.org/article/4123691a17da41c0880e4d3e26cd54c0
Autor:
Stefanie Wojciech, Raise Ahmad, Zakia Belaid-Choucair, Anne-Sophie Journé, Sarah Gallet, Julie Dam, Avais Daulat, Delphine Ndiaye-Lobry, Olivier Lahuna, Angeliki Karamitri, Jean-Luc Guillaume, Marcio Do Cruzeiro, François Guillonneau, Anastasia Saade, Nathalie Clément, Thomas Courivaud, Nawel Kaabi, Kenjiro Tadagaki, Philippe Delagrange, Vincent Prévot, Olivier Hermine, Céline Prunier, Ralf Jockers
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Transforming growth factor-β (TGFβ) regulates many cellular processes. Here the authors show that the orphan G-protein coupled receptor GPR50 can activate the TGFβ receptor I, in the absence of TGFβ, by stabilizing its active conformation and sho
Externí odkaz:
https://doaj.org/article/ee01b8e19b6d47e3a5db8a61ae00a911
Autor:
Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 3, Pp 1-19 (2017)
Abstract G‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to
Externí odkaz:
https://doaj.org/article/8967c8058cf7455eb51b7bdd45452e18
Autor:
Tatsushi Yoshida, Kenta Yamasaki, Kenjiro Tadagaki, Yasumichi Kuwahara, Akifumi Matsumoto, Adèm Sofovic, Noriko Kondo, Toshiyuki Sakai, Tsukasa Okuda
Publikováno v:
International Journal of Oncology
Runt-related transcription factor 1 (RUNX1), which is also known as acute myeloid leukemia 1 (AML1), has been frequently found with genomic aberrations in human leukemia. RUNX1 encodes a transcription factor that can regulate the expression of hemato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9054f7262a52f51678da0ecbd4ee69f9
https://doi.org/10.3892/ijo.2021.5296
https://doi.org/10.3892/ijo.2021.5296
Autor:
Junko Mori, Akiko Kawabata, Huamin Tang, Kenjiro Tadagaki, Hiroyuki Mizuguchi, Kazumichi Kuroda, Yasuko Mori
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137420 (2015)
The human herpesvirus-6 (HHV-6) infection induces cell-cycle arrest. In this study, we found that the HHV-6-encoded U14 protein induced cell-cycle arrest at G2/M phase via an association with the cellular protein EDD, a mediator of DNA-damage signal
Externí odkaz:
https://doaj.org/article/2cffbdc8b9784f1d8635b171f0a3722b
Autor:
Ralf Jockers, Philippe Chavatte, Kenjiro Tadagaki, Nicolas Renault, Francis Cogé, Xavier Laurent, Arnaud Gohier, Nathalie Clement, Jean-Luc Guillaume, Erika Cecon, Philippe Delagrange, Anne-Sophie Journé
Publikováno v:
British Journal of Pharmacology. 175:3281-3297
Background and purpose Recent crystal structures of GPCRs have emphasized the previously unappreciated role of the second extracellular (E2) loop in ligand binding and gating and receptor activation. Here, we have assessed the role of the E2 loop in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3710f48b2ab4459609289d8beb0ad773
https://doi.org/10.1111/bph.14029
https://doi.org/10.1111/bph.14029
Autor:
Nathalie, Clement, Nicolas, Renault, Jean-Luc, Guillaume, Erika, Cecon, Anne-Sophie, Journé, Xavier, Laurent, Kenjiro, Tadagaki, Francis, Cogé, Arnaud, Gohier, Philippe, Delagrange, Philippe, Chavatte, Ralf, Jockers
Publikováno v:
British journal of pharmacology. 175(16)
BACKGROUND AND PURPOSE: Recent crystal structures of GPCRs have emphasized the previously unappreciated role of the second extracellular (E2) loop in ligand binding and gating and receptor activation. Here, we have assessed the role of the E2 loop in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::184bdfc9b0167b4b631f8a225ed01478
https://pubmed.ncbi.nlm.nih.gov/28898928
https://pubmed.ncbi.nlm.nih.gov/28898928