Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Kenjiro Adachi"'
Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells
Autor:
Le Xiong, Erik A Tolen, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler
Publikováno v:
eLife, Vol 11 (2022)
The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not fully understood. Here, we investigate the functions of Oct4 by depleting and subsequently recovering it in mouse
Externí odkaz:
https://doaj.org/article/1d5965331e63415ea1891c5a5bf6e818
Autor:
Rui Fan, Yung Su Kim, Jie Wu, Rui Chen, Dagmar Zeuschner, Karina Mildner, Kenjiro Adachi, Guangming Wu, Styliani Galatidou, Jianhua Li, Hans R. Schöler, Sebastian A. Leidel, Ivan Bedzhov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Embryonic diapause is a state of dormancy with poorly understood mechanisms of embryo intrinsic regulation. Here, the authors show that murine diapause is a dynamic process, where tissue-scale reorganization of the pluripotent lineage is controlled i
Externí odkaz:
https://doaj.org/article/8ca51a4f837f4e888adc4dfe1fda8fa3
Autor:
Lydia Reinhardt, Susanne Kordes, Peter Reinhardt, Michael Glatza, Matthias Baumann, Hannes C.A. Drexler, Sascha Menninger, Gunther Zischinsky, Jan Eickhoff, Claudia Fröb, Prabesh Bhattarai, Guruchandar Arulmozhivarman, Lara Marrone, Antje Janosch, Kenjiro Adachi, Martin Stehling, Eric N. Anderson, Masin Abo-Rady, Marc Bickle, Udai Bhan Pandey, Michell M. Reimer, Caghan Kizil, Hans R. Schöler, Peter Nussbaumer, Bert Klebl, Jared L. Sterneckert
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 502-517 (2019)
Summary: Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem cell-based phenotypic screening and identified small molecules that directly protected neu
Externí odkaz:
https://doaj.org/article/d6324808720f45358bb83abf2c104f0a
Autor:
Ali Sharifi-Zarchi, Daniela Gerovska, Kenjiro Adachi, Mehdi Totonchi, Hamid Pezeshk, Ryan J. Taft, Hans R. Schöler, Hamidreza Chitsaz, Mehdi Sadeghi, Hossein Baharvand, Marcos J. Araúzo-Bravo
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-21 (2017)
Abstract Background DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, the
Externí odkaz:
https://doaj.org/article/7973041d2396419ea4f9b373a5a029e2
Autor:
Mehdi Totonchi, Seyedeh-Nafiseh Hassani, Ali Sharifi-Zarchi, Natalia Tapia, Kenjiro Adachi, Julia Arand, Boris Greber, Davood Sabour, Marcos J. Araúzo-Bravo, Jörn Walter, Mohammad Pakzad, Hamid Gourabi, Hans R. Schöler, Hossein Baharvand
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1275-1290 (2017)
Pluripotent cells emanate from the inner cell mass (ICM) of the blastocyst and when cultivated under optimal conditions immortalize as embryonic stem cells (ESCs). The fundamental mechanism underlying ESC derivation has, however, remained elusive. Re
Externí odkaz:
https://doaj.org/article/bcd1bec9fac247299b59e58f811774dd
Autor:
Kyung Tae Lim, Seung Chan Lee, Yimeng Gao, Kee-Pyo Kim, Guangqi Song, Su Yeon An, Kenjiro Adachi, Yu Jin Jang, Jonghun Kim, Kyoung-Jin Oh, Tae Hwan Kwak, Seon In Hwang, Jueng Soo You, Kinarm Ko, Seung-Hoi Koo, Amar Deep Sharma, Jong-Hoon Kim, Lijian Hui, Tobias Cantz, Hans R. Schöler, Dong Wook Han
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 814-829 (2016)
Recent studies have shown that defined factors could lead to the direct conversion of fibroblasts into induced hepatocyte-like cells (iHeps). However, reported conversion efficiencies are very low, and the underlying mechanism of the direct hepatic r
Externí odkaz:
https://doaj.org/article/3bb0855578b848449a9046f2debd0690
Autor:
Ronan Russell, Marcus Ilg, Qiong Lin, Guangming Wu, André Lechel, Wendy Bergmann, Tim Eiseler, Leonhard Linta, Pavan Kumar P., Moritz Klingenstein, Kenjiro Adachi, Meike Hohwieler, Olena Sakk, Stefanie Raab, Anne Moon, Martin Zenke, Thomas Seufferlein, Hans R. Schöler, Anett Illing, Stefan Liebau, Alexander Kleger
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 1155-1170 (2015)
Pluripotency represents a cell state comprising a fine-tuned pattern of transcription factor activity required for embryonic stem cell (ESC) self-renewal. TBX3 is the earliest expressed member of the T-box transcription factor family and is involved
Externí odkaz:
https://doaj.org/article/ab7f653a565f4e7696bb57ef1afd93c7
Autor:
Gunnar Hargus, Marc Ehrlich, Marcos J. Araúzo-Bravo, Kathrin Hemmer, Anna-Lena Hallmann, Peter Reinhardt, Kee-Pyo Kim, Kenjiro Adachi, Simeon Santourlidis, Foued Ghanjati, Mareike Fauser, Christiana Ossig, Alexander Storch, Jeong Beom Kim, Jens C. Schwamborn, Jared Sterneckert, Hans R. Schöler, Tanja Kuhlmann, Holm Zaehres
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1697-1703 (2014)
The differentiation capability of induced pluripotent stem cells (iPSCs) toward certain cell types for disease modeling and drug screening assays might be influenced by their somatic cell of origin. Here, we have compared the neural induction of huma
Externí odkaz:
https://doaj.org/article/5e515ec7f9674b72846ab253f05544c3
Autor:
Gerrit Fischedick, Guangming Wu, Kenjiro Adachi, Marcos J. Araúzo-Bravo, Boris Greber, Martina Radstaak, Gabriele Köhler, Natalia Tapia, Roberto Iacone, Konstantinos Anastassiadis, Hans R. Schöler, Holm Zaehres
Publikováno v:
Stem Cell Research, Vol 13, Iss 2, Pp 300-315 (2014)
Though expression of the homeobox transcription factor Nanog is generally restricted to pluripotent cells and early germ cells, many contradictory reports about Nanog's involvement in tumorigenesis exist. To address this, a modified Tet-On system was
Externí odkaz:
https://doaj.org/article/2781f584fb2e4fc1a060a58cc22d2cbf
Autor:
Ulf Tiemann, Adele Gabriele Marthaler, Kenjiro Adachi, Guangming Wu, Gerrit Ulf Lennart Fischedick, Marcos Jesús Araúzo-Bravo, Hans Robert Schöler, Natalia Tapia
Publikováno v:
Stem Cell Reports, Vol 2, Iss 3, Pp 351-365 (2014)
Differentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) after overexpressing four transcription factors, of which Oct4 is essential. To elucidate the role of Oct4 during reprogramming, we investigated the immediate transc
Externí odkaz:
https://doaj.org/article/7f804055fa2b47a08e6d88b98eadab35