Výsledky vyhledávání

Akademický článek

Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

Autor: Young A. Yoo, Meejeon Roh, Anum F. Naseem, Barbara Lysy, Mohamed M. Desouki, Kenji Unno, Sarki A. Abdulkadir

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The polycomb repressor protein Bmi1 has a role in self-renewal and tumorigenesis. Here, the authors use lineage tracing to show that Bmi-expressing cells are a distinct population of cells, primarily found in the luminal compartment, which is castrat

Externí odkaz: https://doaj.org/article/723bb9021c454c7c895f31deacc88d0a

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Akademický článek

Establishment of human patient-derived endometrial cancer xenografts in NOD scid gamma mice for the study of invasion and metastasis.

Autor: Kenji Unno, Masanori Ono, Abigail D Winder, Kruti P Maniar, Ajit S Paintal, Yanni Yu, Jian-Jun Wei, John R Lurain, J Julie Kim

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e116064 (2014)

ObjectiveMost endometrial cancers are detected early and have a good prognosis, while some endometrial cancers are highly invasive, metastasize early, and respond suboptimally to therapy. Currently, appropriate model systems to study the aggressive n

Externí odkaz: https://doaj.org/article/013d57a3cfe64d4bb55de21de84649d5

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Akademický článek

Role of stem cells in human uterine leiomyoma growth.

Autor: Masanori Ono, Wenan Qiang, Vanida Ann Serna, Ping Yin, John S Coon, Antonia Navarro, Diana Monsivais, Toshiyuki Kakinuma, Matthew Dyson, Stacy Druschitz, Kenji Unno, Takeshi Kurita, Serdar E Bulun

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36935 (2012)

Uterine leiomyoma is the most common benign tumor in reproductive-age women. Each leiomyoma is thought to be a benign monoclonal tumor arising from a single transformed myometrial smooth muscle cell; however, it is not known what leiomyoma cell type

Externí odkaz: https://doaj.org/article/d32f9310aad54d69b2c660fdb1d18b49

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Data from Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer

Autor: Sarki A. Abdulkadir, Yue Zhao, Himisha Beltran, Sheng-Yu Ku, Young A. Yoo, Huiying Han, Vinay Sagar, Hanlin Mok, Barbara Lysy, Yara Rodriguez, Rajita Vatapalli, Sahithi Pamarthy, Zachary R. Chalmers, Kenji Unno

Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer with poor prognosis, and there is a critical need for novel therapeutic approaches. NEPC is associated with molecular perturbation of several pathways, including amplif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bb69c104c9b6c576d41fdd38f4bbd5e
https://doi.org/10.1158/0008-5472.c.6512901.v1

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Data from A Genome-Wide CRISPR Activation Screen Identifies PRRX2 as a Regulator of Enzalutamide Resistance in Prostate Cancer

Autor: Sarki A. Abdulkadir, Huiying Han, Maha Hussain, Barbara Lysy, Jindan Yu, Vinay Sagar, Rajita Vatapalli, Young A. Yoo, Zachary R. Chalmers, Mihai I. Truica, Kenji Unno, Yara Rodríguez

Androgen receptor (AR) pathway inhibitors are the mainstay treatment for advanced prostate cancer, but resistance to therapy is common. Here, we used a CRISPR activation screen in metastatic castration-sensitive prostate cancer cells to identify gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::895b10adb5255602a915ab5a2543f5ab
https://doi.org/10.1158/0008-5472.c.6513723.v1

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