Výsledky vyhledávání - "Kenji Uemura"

Syntheses of cyclopentyl nucleoside (−)-neplanocin A through tetrazole-fragmentation from cyanophosphates

Autor: Kenji Uemura, Yoshihide Usami, Shinya Harusawa, Hiroki Yoneyama

Publikováno v: Tetrahedron. 74:2143-2150

Abstact We recently reported a novel synthetic method for five-membered unsaturated cyclic compounds from ketones involving cyanophosphates (CPs) under neutral conditions, in which alkylidene carbenes generated through tetrazole-fragmentation undergo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41dc191584e355306ca3ad759d9459ef
https://doi.org/10.1016/j.tet.2018.03.020

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Synthesis of five-membered unsaturated compounds from ketones via cyanophosphates under neutral conditions: [1,5]-C H insertion of alkylidene carbenes generated by tetrazole fragmentation

Autor: Hiroki Yoneyama, Yoshihide Usami, Kenji Uemura, Shinya Harusawa

Publikováno v: Tetrahedron. 73:6109-6117

Cyanophosphates (CPs) can easily be prepared via the reactions of carbonyl compounds with diethyl phosphorocyanidate (DEPC) in the presence of LiCN (cat.) under non-aqueous conditions. Treatment of ketone-derived CPs with TMSN 3 /Bu 2 SnO (cat.) in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5517e5faed3eb3d201aee810a6551fa4
https://doi.org/10.1016/j.tet.2017.08.054

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Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells

Autor: Masami Ishibashi, Midori A. Arai, Naoki Ishikawa, Akiko Suganami, Kenji Uemura, Mitsuha Tanaka, Thaworn Kowithayakorn, Noriko Sugimitsu, Takashi Koyano, Yutaka Tamura

Publikováno v: Chemical Science. 7:1514-1520

The Hes1 dimer inhibitor, agalloside (2), which can accelerate the differentiation of neural stem cells is described. Six natural products, including one new natural product, which bind to Hes1 were rapidly isolated by a developed "target protein ori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dc2757ab1bd3e0e4c4ba51cb043f103
https://doi.org/10.1039/c5sc03540f

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Efficient Synthesis of N-[4-(4-Chlorophenyl)butyl]-S-(3-piperidinopropyl)isothiourea (OUP-186) and Its Analogues Using 2-Nitrophenylacetyl Isothiocyanate: Application to Novel Histamine H3R Antagonists

Autor: Kenji Uemura, Yoshihide Usami, Hiroki Yoneyama, Takuji Magata, Masanori Takaoka, Satoshi Tanaka, Shinya Harusawa

Publikováno v: Synthesis. 47:1291-1302

A potent histamine H3 receptor antagonist OUP-186 with an S-alkyl-N-alkylisothiourea structure was synthesized using 3-phenylpropanoyl isothiocyanate (PPI) as an SCN source. The synthetic route was significantly improved by replacing 3-phenylpropanoy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8942900f7f6eab6ea73f8ad81908b7b1
https://doi.org/10.1055/s-0034-1380345

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Naturally occurring FANCF–Hes1 complex inhibitors from Wrightia religiosa

Autor: Nozomi Hamahiga, Tagrid Kaddar, Takashi Koyano, Midori A. Arai, Kenji Uemura, Thaworn Kowithayakorn, Madeleine Carreau, Masami Ishibashi, Naoki Ishikawa

Publikováno v: MedChemComm. 6:455-460

The isolation and evaluation of inhibitors of Fanconi F protein (FANCF) – hairy and enhancer of split 1 (Hes1) complex are described. A high-throughput screening assay for small-molecule inhibitors of the FANCF–Hes1 complex was realized. Successf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b6febe4618f8e65491bbfa3fd021b46
https://doi.org/10.1039/c4md00495g

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Transformation of Carbonyl Compounds into Homologous Alkynes under Neutral Conditions: Fragmentation of Tetrazoles Derived from Cyanophosphates

Autor: Yoshihide Usami, Kenji Uemura, Masahiro Numata, Shinya Harusawa, Hiroki Yoneyama

Publikováno v: The Journal of organic chemistry. 82(11)

Cyanophosphates (CPs) can be easily prepared from either ketones or aldehydes, and their reaction with NaN3–Et3N·HCl results in the formation of azidotetrazoles. Under microwave irradiation, successive fragmentation of the azidotetrazoles generate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63aa1ff4d1bc47f212068e421b2c8ce
https://pubmed.ncbi.nlm.nih.gov/28470066

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Analysis of Prolactin Gene Expression and Cleaved Prolactin Variants in the Mouse Testis and Spermatozoa

Autor: Kenji Uemura, Michiyo Ishida, Shinya Fukuta, Makoto Yoshida, Mieko Iijima, Kotaro Horiguchi, Toshio Harigaya

Publikováno v: Journal of Reproduction and Development. 56:567-574

Prolactin (PRL) has long been known to be a hormone responsible for mammary gland development and lactation in females, whereas its role in males is still unclear. Thus, we investigated male mouse (m) PRL protein and mRNA expression in spermatozoa at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e32afa20d2edd4fcb12b4c7da701bf
https://doi.org/10.1262/jrd.09-163n

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Induced permutation automata and coverings of strongly connected automata

Autor: Kimio Sugita, Kenji Uemura, Takeo Yaku

Publikováno v: Discrete Applied Mathematics. 91:243-249

Let A = (S, Σ, N) be a strongly connected automaton and e be a minimal idempotent of characteristic semigroup B(A). The unique (up to isomorphism) subgroup eB(A)e is a very important group in automaton automorphism theory. For example, the automorph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4f4acd21bc9547b11c8dfb862d93a8
https://doi.org/10.1016/s0166-218x(98)00150-4

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