Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Kenji Osafune"'
Autor:
Hiraku Tsujimoto, Azusa Hoshina, Shin-Ichi Mae, Toshikazu Araoka, Wang Changting, Yoshihiro Ijiri, May Nakajima-Koyama, Satoko Sakurai, Kazusa Okita, Ken Mizuta, Akira Niwa, Megumu K. Saito, Mitinori Saitou, Takuya Yamamoto, Cecilia Graneli, Kevin J. Woollard, Kenji Osafune
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113602- (2024)
Summary: Recent regenerative studies using human pluripotent stem cells (hPSCs) have developed multiple kidney-lineage cells and organoids. However, to further form functional segments of the kidney, interactions of epithelial and interstitial cells
Externí odkaz:
https://doaj.org/article/0ff925a8f95745d09e7a299bf70b6721
Autor:
Ryuichiro Hirayama, Kosuke Toyohara, Kei Watanabe, Takeya Otsuki, Toshikazu Araoka, Shin-Ichi Mae, Tomoko Horinouchi, Tomohiko Yamamura, Keisuke Okita, Akitsu Hotta, Kazumoto Iijima, Kandai Nozu, Kenji Osafune
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Alport syndrome (AS) is a hereditary glomerulonephritis caused by COL4A3, COL4A4 or COL4A5 gene mutations and characterized by abnormalities of glomerular basement membranes (GBMs). Due to a lack of curative treatments, the condition proceed
Externí odkaz:
https://doaj.org/article/d35615f2c8824439a7a88aa52196dc4a
Autor:
Tomoya Mori, Toshiro Takase, Kuan-Chun Lan, Junko Yamane, Cantas Alev, Azuma Kimura, Kenji Osafune, Jun K. Yamashita, Tatsuya Akutsu, Hiroaki Kitano, Wataru Fujibuchi
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-27 (2023)
Abstract Background Bioinformatics capability to analyze spatio–temporal dynamics of gene expression is essential in understanding animal development. Animal cells are spatially organized as functional tissues where cellular gene expression data co
Externí odkaz:
https://doaj.org/article/c7beb770fa2146338f81cea694edbec4
Autor:
Ryo Ito, Azuma Kimura, Yurie Hirose, Yu Hatano, Atsushi Mima, Shin-Ichi Mae, Yamato Keidai, Toshihiro Nakamura, Junji Fujikura, Yohei Nishi, Akira Ohta, Taro Toyoda, Nobuya Inagaki, Kenji Osafune
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract For pluripotent stem cell (PSC)-based regenerative therapy against diabetes, the differentiation efficiency to pancreatic lineage cells needs to be improved based on the mechanistic understanding of pancreatic differentiation. Here, we aimed
Externí odkaz:
https://doaj.org/article/df2cb19d80214e9ca8bdf82af4846cfd
Autor:
Yuta Yamamura, Kengo Furuichi, Yasuhiro Murakawa, Shigeki Hirabayashi, Masahito Yoshihara, Keisuke Sako, Shinji Kitajima, Tadashi Toyama, Yasunori Iwata, Norihiko Sakai, Kazuyoshi Hosomichi, Philip M. Murphy, Atsushi Tajima, Keisuke Okita, Kenji Osafune, Shuichi Kaneko, Takashi Wada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract PAX2 is a transcription factor essential for kidney development and the main causative gene for renal coloboma syndrome (RCS). The mechanisms of PAX2 action during kidney development have been evaluated in mice but not in humans. This is a c
Externí odkaz:
https://doaj.org/article/441f6fd5b00847cfaaed60ac37342f8f
Autor:
Naoko Katagiri, Hirofumi Hitomi, Shin-Ichi Mae, Maki Kotaka, Li Lei, Takuya Yamamoto, Akira Nishiyama, Kenji Osafune
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Erythropoietin (EPO) is a crucial hormone for erythropoiesis and produced by adult kidneys. Insufficient EPO production in chronic kidney disease (CKD) can cause renal anemia. Although hypoxia-inducible factors (HIFs) are known as a main reg
Externí odkaz:
https://doaj.org/article/fb684e94675646a998a711fcfd4223f2
Autor:
Takayuki Hamabata, Katsutsugu Umeda, Kagehiro Kouzuki, Takayuki Tanaka, Tomoo Daifu, Seishiro Nodomi, Satoshi Saida, Itaru Kato, Shiro Baba, Hidefumi Hiramatsu, Mitsujiro Osawa, Akira Niwa, Megumu K. Saito, Yasuhiko Kamikubo, Souichi Adachi, Yoshiko Hashii, Akira Shimada, Hiroyoshi Watanabe, Kenji Osafune, Keisuke Okita, Tatsutoshi Nakahata, Kenichiro Watanabe, Junko Takita, Toshio Heike
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/b950f5eee1ed4eed9297ec002e679c2f
Autor:
Shogo Nishimoto, Tomohiro Mizuno, Kazuo Takahashi, Fumihiko Nagano, Yukio Yuzawa, Akira Nishiyama, Kenji Osafune, Hirofumi Hitomi, Tadashi Nagamatsu
Publikováno v:
FEBS Open Bio, Vol 10, Iss 3, Pp 427-433 (2020)
Renal anemia in chronic kidney disease is treated with recombinant human erythropoietin (rhEPO). However, some patients with anemia do not respond well to rhEPO, emphasizing the need for a more biocompatible EPO. Differentiation protocols for hepatic
Externí odkaz:
https://doaj.org/article/757d729b4e104452891a5aacfda045ea
Autor:
Takahito Minami, Takamichi Ishii, Kentaro Yasuchika, Ken Fukumitsu, Satoshi Ogiso, Yuya Miyauchi, Hidenobu Kojima, Takayuki Kawai, Ryoya Yamaoka, Yu Oshima, Hiroshi Kawamoto, Maki Kotaka, Katsutaro Yasuda, Kenji Osafune, Shinji Uemoto
Publikováno v:
Regenerative Therapy, Vol 10, Iss , Pp 127-133 (2019)
Introduction: Liver transplantation is currently the only curative therapy for end-stage liver failure; however, establishment of alternative treatments is required owing to the serious donor organ shortage. Here, we propose a novel model of hybrid t
Externí odkaz:
https://doaj.org/article/9aae3627cd794fa183532b0a18f02ace
Autor:
Eiji Kobayashi, Masaki Nagaya, Koki Hasegawa, Masahito Watanabe, Kazuaki Nakano, Kazutoshi Okamoto, Takeshi Yamada, Ayuko Uchikura, Kenji Osafune, Harumasa Yokota, Taiji Nagaoka, Hitomi Matsunari, Kazuhiro Umeyama, Hiromitsu Nakauchi, Hiroshi Nagashima
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 2 (2020)
Introduction Pancreatic duodenum homeobox 1 (Pdx1) expression is crucial for pancreatic organogenesis and is a key regulator of insulin gene expression. Hairy and enhancer of split 1 (Hes1) controls tissue morphogenesis by maintaining undifferentiate
Externí odkaz:
https://doaj.org/article/cf1506b1ebb04c9eb6e8b1edd15e7d96