Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kenji Okuse"'
Publikováno v:
PAIN Reports, Vol 4, Iss 5, p e786 (2019)
Abstract. Neuropathic pain (NP) remains an area of considerable unmet medical need. A persistent challenge in the management of NP is to target the specific mechanisms leading to a change from normal to abnormal sensory perception while ensuring that
Externí odkaz:
https://doaj.org/article/94a1441823af4812b248c582e063c318
Publikováno v:
PLoS ONE, Vol 8, Iss 5 (2013)
Externí odkaz:
https://doaj.org/article/5eb7cdf798bf43ea9f6d5726aaf31ce9
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e40079 (2012)
Voltage-gated sodium channels (VGSCs) play a key role in the initiation and propagation of action potentials in neurons. Na(V)1.8 is a tetrodotoxin (TTX) resistant VGSC expressed in nociceptors, peripheral small-diameter neurons able to detect noxiou
Externí odkaz:
https://doaj.org/article/0003d609adac43bfbfc896edf5519968
Autor:
Andrew S.C. Rice, Kersti Karu, David L.H. Bennett, Ana Antunes-Martins, Benjamin Thomas, Min Fang, Richard S. Swanwick, William A. Foster, Eiji Yoshimi, Stephen B. McMahon, Amparo Novejarque-Gadea, Kenji Okuse
Publikováno v:
Journal of Proteome Research. 19:1592-1619
Pain and emotional distress have a reciprocal relation. The amygdala has been implicated in emotional processing. The central nucleus of the amygdala (CeA) receives nociceptive information from the dorsal horn of spinal cord and is responsible for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a03f7bd04099345bd0aa299a27fd994
https://doi.org/10.1021/acs.jproteome.9b00805
https://doi.org/10.1021/acs.jproteome.9b00805
Autor:
Kenji Okuse, Alessandro Pristerà, Rustem Onkal, Mustafa B. A. Djamgoz, Nahit Rizaner, Scott P. Fraser
Publikováno v:
European Biophysics Journal. 45:735-748
The possible association of intracellular Ca2+ with metastasis in human cancer cells is poorly understood. We have studied Ca2+ signaling in human prostate and breast cancer cell lines of strongly versus weakly metastatic potential in a comparative a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45e39f62bc879bf1e19285a2c3569dc
https://doi.org/10.1007/s00249-016-1170-x
https://doi.org/10.1007/s00249-016-1170-x
Autor:
Kenji Okuse, Alessandro Pristerà
Publikováno v:
The Neuroscientist. 18:70-81
Multiple plasma membrane proteins such as ion transporters and ion channels are involved in electrogenesis by setting resting membrane potentials and triggering/propagating action potentials. Recent findings strongly suggest that some of these membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6172723afbcc7791cb204d4c481b7940
https://doi.org/10.1177/1073858410393977
https://doi.org/10.1177/1073858410393977
Autor:
Misbah Malik-Hall, John N. Wood, Francois Rugiero, Mark D. Baker, Dongmin Shao, Kwok-Ming Yao, Kathryn S.E. Cheah, Kenji Okuse, Bjarke Abrahamsen, W.-Y.Louisa Poon
Publikováno v:
Molecular and Cellular Neurosciences
The voltage-gated sodium channel NaV1.8 is expressed exclusively in nociceptive sensory neurons and plays an important role in pain pathways. NaV1.8 cannot be functionally expressed in non-neuronal cells even in the presence of β-subunits. We have p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead94c5c2a9b8e65e1f8c77f49316ed8
https://doi.org/10.1016/j.mcn.2009.07.003
https://doi.org/10.1016/j.mcn.2009.07.003
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 41:1471-1481
Voltage-gated sodium channels (VGSCs), classically known to play a central role in excitability and signalling in nerves and muscles, have also been found to be expressed in a range of ‘non-excitable’ cells, including lymphocytes, fibroblasts and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7275351f8271a24cb181fffcd3cfc121
https://doi.org/10.1016/j.biocel.2009.01.016
https://doi.org/10.1016/j.biocel.2009.01.016
Autor:
Anthony H. Dickenson, J. Blackbeard, Andrew S.C. Rice, T. Pheby, F. Hasnie, Victoria C.J. Wallace, Stephen B. McMahon, Ramine Hosseini, Kenji Okuse, Klio Maratou, Christine A. Orengo, Nipurna Jina
Publikováno v:
European Journal of Pain (London, England)
To elucidate the mechanisms underlying peripheral neuropathic pain in the context of HIV infection and antiretroviral therapy, we measured gene expression in dorsal root ganglia (DRG) of rats subjected to systemic treatment with the anti-retroviral a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f031247965080665053bda95abe2b52
https://doi.org/10.1016/j.ejpain.2008.05.011
https://doi.org/10.1016/j.ejpain.2008.05.011
Autor:
Mark D. Baker, Volker Gerke, Thomas Foulkes, Elizabeth A. Matthews, Anthony H. Dickenson, Kenji Okuse, John N. Wood, Tim Lane, Mohammed A. Nassar
Publikováno v:
The Journal of Neuroscience. 26:10499-10507
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel NaV1.8, TWIK-related acid-sensitive K+channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906a01abdbd5e64a108eed6b7f4b2624
https://doi.org/10.1523/jneurosci.1997-06.2006
https://doi.org/10.1523/jneurosci.1997-06.2006