Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Kenji OKUDA"'
Publikováno v:
Viruses, Vol 16, Iss 7, p 1094 (2024)
Adenoviruses are non-enveloped DNA viruses that cause a wide range of symptoms, from mild infections to life-threatening diseases in a broad range of hosts. Due to the unique characteristics of these viruses, they have also become a vehicle for gene-
Externí odkaz:
https://doaj.org/article/db98edf17dbc49d698a9a98c685ebfca
Autor:
Akira Aoki, Hirokazu Adachi, Yoko Mori, Miyabi Ito, Katsuhiko Sato, Kenji Okuda, Toru Sakakibara, Yoshinori Okamoto, Hideto Jinno
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. As of March 2022, Omicron variant BA.2 is rapidly replacing variant BA.1. As variant BA.2 may cause more severe disease than variant BA
Externí odkaz:
https://doaj.org/article/25b584ab1ca94955935375d943c513f1
Autor:
Akira Aoki, Hirokazu Adachi, Yoko Mori, Miyabi Ito, Katsuhiko Sato, Masayoshi Kinoshita, Masahiro Kuriki, Kenji Okuda, Toru Sakakibara, Yoshinori Okamoto, Hideto Jinno
Publikováno v:
Viruses, Vol 14, Iss 11, p 2401 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant BA.5 emerged as of February 2022 and replaced the earlier Omicron subvariants BA.1 and BA.2. COVID-19 genomic surveillance should be continued as new variants seem to sub
Externí odkaz:
https://doaj.org/article/ae5d800d3c554ccebb600de64e0ad31e
Autor:
Takehiro Ura, Masaki Takeuchi, Tatsukata Kawagoe, Nobuhisa Mizuki, Kenji Okuda, Masaru Shimada
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1367 (2022)
The induction of T cell-mediated immunity is crucial in vaccine development. The most effective vaccine is likely to employ both cellular and humoral immune responses. The efficacy of a vaccine depends on T cells activated by antigen-presenting cells
Externí odkaz:
https://doaj.org/article/a416eb688caa4d5d8f09f3a6c0d83aed
Publikováno v:
Vaccines, Vol 2, Iss 3, Pp 624-641 (2014)
Viral vectors are promising tools for gene therapy and vaccines. Viral vector-based vaccines can enhance immunogenicity without an adjuvant and induce a robust cytotoxic T lymphocyte (CTL) response to eliminate virus-infected cells. During the last s
Externí odkaz:
https://doaj.org/article/914cc6cedbd047159fc78aadb00323c7
Publikováno v:
Vaccines, Vol 2, Iss 1, Pp 89-106 (2014)
The advantages of genetic immunization of the new vaccine using plasmid DNAs are multifold. For example, it is easy to generate plasmid DNAs, increase their dose during the manufacturing process, and sterilize them. Furthermore, they can be stored fo
Externí odkaz:
https://doaj.org/article/732a1876bc7b41beb6ecdd5e66eb06bb
Autor:
Yuichi Tamura, Kenji Hamajima, Kiyohiko Matsui, Shunsuke Yanoma, Masato Narita, NobuyoshiI Tajima, Ke-Qin Xin, Dennis Klinman, Kenji Okuda
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 541-549 (2005)
This work examines whether administering the F(ab´)2 fragment of an IgG1 monoclonal antibody (mAb) targeting the N-terminal 1–13 amino acids of the β-amyloid peptide (Aβ mAb) reduces amyloid deposition in Alzheimer's disease (AD). The F(ab′)2
Externí odkaz:
https://doaj.org/article/bbf093415f3749b0bcd6cbe0e850fab0
Autor:
Masaru Shimada, Shinya Abe, Toru Takahashi, Kazumasa Shiozaki, Mitsue Okuda, Hiroaki Mizukami, Dennis M Klinman, Keiya Ozawa, Kenji Okuda
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57606 (2013)
We previously reported on a monoclonal antibody (mAb) that targeted amyloid beta (Aß) protein. Repeated injection of that mAb reduced the accumulation of Aß protein in the brain of human Aß transgenic mice (Tg2576). In the present study, cDNA enco
Externí odkaz:
https://doaj.org/article/bb5584f2f78548e1b4006193324b91db
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30302 (2012)
Adenovirus vector-based vaccine is a promising approach to protect HIV infection. However, a recent phase IIb clinical trial using the vector did not show its protective efficacy against HIV infection. To improve the vaccine, we explored the transgen
Externí odkaz:
https://doaj.org/article/312fe46100844aeab809b8fb306f5b15
Autor:
Yuichiro Tane, Yoshito Okada, Shusaku Ohira, Yoshiro Taguchi, Yayoi Sakatoku, Yosuke Ishida, Sojiro Akiyama, Heinoshin Ichino, Kenji Okuda, Shuzo Takahashi
Publikováno v:
The Japanese Journal of Gastroenterological Surgery. 55:425-431
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::142cd905998cb70cda0f696bf44d4bbd
https://doi.org/10.5833/jjgs.2021.0088
https://doi.org/10.5833/jjgs.2021.0088