Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kenji Momota"'
Autor:
Masakatsu Kaneko, Toshinori Agatsuma, Koji Abe, Takashi Nishigaki, Rika Koga, Toshiyuki Kosaka, Junko Sone, Makoto Koizumi, Satoshi Kimura, Hitoshi Hotoda, Hidehiko Furukawa, Toshinori Sankyo Bio-Sc Ohmine, Kenji Momota, Shinya Tsutsumi, Kaoru Shimada
Publikováno v:
Journal of Medicinal Chemistry. 41:3655-3663
A series of hexadeoxyribonucleotides (6-mers), d(TGGGAG), substituted with a variety of aromatic groups at the 5'-end were synthesized and tested for anti-human immunodeficiency virus type 1 (HIV-1) activity. While unmodified d(TGGGAG) (31) had no an
Autor:
Koji Abe, Toshinori Ohmine, Takashi Nishigaki, Masakatsu Kaneko, Hidehiko Furukawa, Toshiyuki Kosaka, Toshinori Agatsuma, Makoto Koizumi, Satoshi Kimura, Junko Sone, Hitoshi Hotoda, Rika Koga, Kenji Momota, Shinya Tsutsumi, Kaoru Shimada
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:2235-2243
We have determined that hexadeoxyribonucleotides (5′TGGGAG3′), with modified aromatic groups such as a trityl group at the 5′-end, have anti-HIV-1 activity in vitro. The 6-mer bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5′-end had
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:497-505
We have investigated the biological and antiviral properties of a dimethoxytrityl (DmTr)-linked guanine (G)-rich oligodeoxynucleotide (ODN) with a phosphodiester linkage, SA-1042 (5' DmTr-TGGGAGGTGGGTCTG 3'), that has been shown to exhibit potent inh
Autor:
Toshiyuki Kosaka, Makoto Koizumi, Koji Abe, Hidehiko Furukawa, Rika Koga, Kenji Momota, Satoshi Kimura, Takashi Nishigakit, Kaoru Shimada, Hitoshi Hotoda, Toshinori Ohmine, Masakatsu Kaneko
Publikováno v:
Nucleosides and Nucleotides. 16:1205-1208
It has been determined that hexadeoxyribonucleotides (5′TGGGAG3′), which have modified aromatic groups such as the trityl group at the 5′-end, exhibit anti-HIV-1 activity in vitro. The 6-mer (S-1443) bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) gr
Autor:
Toshinori Agatsuma, Satoshi Kimura, Hidehiko Furukawa, Kenji Momota, Ikue Yamamoto, Kaoru Shimada
Publikováno v:
Antisense and Nucleic Acid Drug Development. 7:167-175
It has been shown in previous reports that a guanine-rich phosphodiester oligonucleotide bearing a dimethoxytrityl (DmTr) residue on its 5'-terminal. DmTr-TGGGAGGTGGGTCTG (SA-1042), is an inhibitor of HIV-1 infection in vitro. SA-1042 interfered with
Autor:
Rika Koga, Takeshi Kinoshita, Kaoru Shimada, Makoto Koizumi, Toshinori Ohmine, Takashi Nishigaki, Masakatsu Kaneko, Hitoshi Hotoda, Hidehiko Furukawa, Satoshi Kimura, Kenji Momota
Publikováno v:
Nucleosides and Nucleotides. 15:531-538
Hexadeoxyribonucleotides (6-mers) having a 5′-TGGGAG-3′ sequence bearing hydrophobic substituents at their 5′-ends via phosphodiester linkages were prepared and evaluated for anti-HIV-1 activity in vitro. Some of these modified 6-mers showed we
Autor:
Kawu Shimada, Kenji Momota, Takemichi Nakamura, Masakatsu Kaneko, Satcshi Kimura, Hitoshi Hotoda, Hidehiko Furukawa
Publikováno v:
Nucleosides and Nucleotides. 13:1375-1395
5′-End-modified pentadecadeoxyribonucleotides (15mers) with a sequence complementary to the tat 2nd splicing acceptor region of human immunodeficiency virus type 1 (HIV-1) were prepared and evaluated for anti-HIV-1 activity. The structures of modif
Autor:
Setsuko Ida, Kunio Ohyama, Kaoru Shimada, Yuko Shibuya, Yutaka Takebe, Nobuyuki Kobayashi, Kenji Momota, Satoshi Kimura, Tatsuo Shioda, Shinichi Oka
Publikováno v:
AIDS Research and Human Retroviruses. 10:271-277
We encountered a case of HIV-1 infection in a previously healthy man, which was characterized by rapid progression to AIDS and death within 7 months in association with high levels of antigenemia throughout the clinical course and no humoral immune r
Autor:
Toshinori Agatsuma, Kaoru Shimada, Hidehiko Furukawa, Kenji Momota, Satoshi Kimura, Ikue Yamamoto
Publikováno v:
Nucleic Acids Research. 22:5621-5627
Oligodeoxyribonucleotides (ODN) linked at their 5'-end with dimethoxytrityl (DmTr) residue were examined for antiviral activities against human immunodeficiency virus type 1 (HIV-1). We found that guanine-rich oligonucleotides exhibit anti-HIV activi
Publikováno v:
ChemInform. 26