Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Kenji Mizojiri"'
1
Autoradiographic Studies on the Binding Sites of 125I-Adrenomedullin in Rat Tissues
Autor: Kazuo Kitamura, Tanenao Eto, Mitsuru Notoya, Hiroshi Hasegawa, Kenji Mizojiri, Kazuhiro Inazawa, Vinci Mizuhira, Kenji Kangawa
Publikováno v: ACTA HISTOCHEMICA ET CYTOCHEMICA. 31:335-343
Adrenomedullin (AM) is a novel hypotensive peptide isolated from the human pheochromocytoma. In the present study, 125I-AM was intravenously administered to rats and its distribution was examined by autoradiographic (ARG) techniques using wholebody,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebe8ed4f5a48b04094eaf1a8366a0a1b
https://doi.org/10.1267/ahc.31.335
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2
High resolution localization of endothelin receptors in rat renal medulla
Autor: Vinci Mizuhira, Tsuneyuki Ebara, Hiroshi Iwao, Shokei Kim, Tokihito Yukimura, Takeshi Matsuura, Kenji Mizojiri, Mitsuru Notoya, Keifu Song, Katsuyuki Miura
Publikováno v: Kidney International. 50:135-147
High resolution localization of endothelin receptors in rat renal medulla. The cellular localization of endothelin receptors in the inner medulla of the rat kidney was investigated by using high resolution light and electron microscopic autoradiograp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8dced9373bf45d25b315deffcbf42f
https://doi.org/10.1038/ki.1996.296
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3
Effects of Lisinopril on the Structure of Renal Arterioles
Autor: Mitsuru Notoya, Masuhisa Nakamura, Kenji Mizojiri
Publikováno v: Hypertension. 27:364-370
Abstract We investigated the effect of long-term administration of the angiotensin-converting enzyme inhibitor lisinopril on renal arterioles in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) using a morphometric method and vascula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a148964d77a7fdbc63fa3675ae048abb
https://doi.org/10.1161/01.hyp.27.3.364
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4
Estimation of Drug Accumulation in Repeated-Dose Tissue Distribution Studies
Autor: Kenji Mizojiri, Ryo Norikura
Publikováno v: Drug Metabolism and Pharmacokinetics. 11:147-159
The present study used the published data to examine the relationship between accumulation factor (predicted value) and accumulation ratio (observed value) of a compound as a ratio of tissue concentration at 24 hr after single administration to that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49044c9ec1573dd20b4b05f26142610f
https://doi.org/10.2133/dmpk.11.147
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6
Identification of Metabolites of a New Thromboxane A2 Receptor Antagonist, S-1452, in Rats
Autor: Yuzo Nakagawa, Junko Kikuchi, Yoshihiro Terui, Kouji Iwatani, Takeo Yoshimori, Ryo Norikura, Kenji Mizojiri, Machiko Nakanishi
Publikováno v: Drug Metabolism and Pharmacokinetics. 8:67-81
The metabolism of S-1452, calcium (5Z)-7-[(1R, 2S, 3S, 4S)-3-phenylsulfonylaminobicyclo[2.2.1]hept-2-yl]-5-heptenoate hydrate, a new TXA2 receptor antagonist, in rats was studied. Twelve unconjugated metabolites including the unchanged free acid of S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00e0c5e1935d35964e0432607878680e
https://doi.org/10.2133/dmpk.8.67
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7
Studies on the Metabolic Fate of a New Thromboxane A2 Receptor Antagonist, S-1452. (II). Distribution and Excretion after Single and Repeated Oral Administration to Rats
Autor: Machiko Nakanishi, Shinya Futaguchi, Hiroshi Okabe, Yuka Iwamoto, Ryo Norikura, Kenji Mizojiri, Hideo Tanaka, Takeo Yoshimori
Publikováno v: Drug Metabolism and Pharmacokinetics. 8:97-105
The tissue distribution and excretion of S-1452 were studied in rats after a single and repeated oral administration of 14C-S-1452 at a dose of 5mg/kg or 5mg/kg/day for 10 days. 1. The level of radioactivity in the liver was markedly higher than thos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::271aea0c4d424d9a4de5e61a4ff9c35b
https://doi.org/10.2133/dmpk.8.97
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8
Studies on the Metabolic Fate of a New Thromboxane A2 Receptor Antagonist, S-1452. (III). Transfer into the Fetus and Milk in Rats
Autor: Yuka Iwamoto, Takeo Yoshimori, Kenji Mizojiri, Ryo Norikura, Machiko Nakanishi, Hideo Tanaka
Publikováno v: Drug Metabolism and Pharmacokinetics. 8:107-112
Transfer of radioactivity into the fetus and milk were studied after a single oral administration of 14C-S-1452 at a dose of 5mg/kg in pregnant rats on 19 days of gestation and in lactating rats. 1. In whole body autoradiography, distribution pattern
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc5258ae4ea36da3fd7f8e05ae8b059c
https://doi.org/10.2133/dmpk.8.107
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9
Studies on the Metabolic Fate of a New Thromboxane A2 Receptor Antagonist, S-1452. (I). Absorption, Distribution, Metabolism and Excretion after Single Administration to Rats
Autor: Machiko Nakanishi, Kenji Mizojiri, Tsuyoshi Murakami, Ryo Norikura, Takeo Yoshimori
Publikováno v: Drug Metabolism and Pharmacokinetics. 8:83-96
The absorption, distribution, metabolism and excretion of S-1452, a new thromboxane A2 receptor antagonist, were studied after a single oral or intravenous administration of 14C-labelled compounds at a dose of 5mg/kg to fasted and non-fasted rats. Al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e72b1b493bad35213f6ecc21f64e758a
https://doi.org/10.2133/dmpk.8.83
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