Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kenji Kubara"'
Autor:
Huan-Ting Lin, Masatoshi Takagi, Kenji Kubara, Kazuto Yamazaki, Fumiko Michikawa, Takashi Okumura, Takuya Naruto, Tomohiro Morio, Koji Miyazaki, Hideki Taniguchi, Makoto Otsu
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Although oncogenic RAS mutants are thought to exert mutagenic effects upon blood cells, it remains uncertain how a single oncogenic RAS impacts non-transformed multipotent hematopoietic stem or progenitor cells (HPCs). Such potent
Externí odkaz:
https://doaj.org/article/41b677ec4b61423aabb1d9bf49e2ae0f
Autor:
Kazuto Yamazaki, Kenji Kubara, Satoko Ishii, Keita Kondo, Yuta Suzuki, Takayuki Miyazaki, Kaoru Mitsuhashi, Masashi Ito, Kappei Tsukahara
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 210-226 (2023)
Ornithine transcarbamylase (OTC) plays a significant role in the urea cycle, a metabolic pathway functioning in the liver to detoxify ammonia. OTC deficiency (OTCD) is the most prevalent urea cycle disorder. Here, we show that intravenously delivered
Externí odkaz:
https://doaj.org/article/48ee6ba359df4e7ca01a74bc5b65dc51
Autor:
Yuta Suzuki, Takayuki Miyazaki, Hiroki Muto, Kenji Kubara, Yohei Mukai, Ryuji Watari, Shinya Sato, Keita Kondo, Shin-ichi Tsukumo, Koji Yasutomo, Masashi Ito, Kappei Tsukahara
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 226-240 (2022)
mRNA and lipid nanoparticles have emerged as powerful systems for the preparation of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The emergence of novel variants or the necessity of cold chain logistics for
Externí odkaz:
https://doaj.org/article/4054f9f2cc084521a4b687b1b0017f6f
Autor:
Kazuto Yamazaki, Kenji Kubara, Satoko Ishii, Peng Li, Ryo Dairiki, Taro Hihara, Yuta Ishizuka, Yukina Izumi, Minoru Kumai, Tsutomu Kamisako, Hiroyoshi Ishizaki, Hideyuki Sato, Hideki Masaki, Naoaki Mizuno, Kaoru Mitsuhashi, Masashi Ito, Sanae Hamanaka, Tomoyuki Yamaguchi, Motoo Watanabe, Fumihiro Sugiyama, Hiromitsu Nakauchi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Blastocyst complementation is an intriguing way of generating humanized animals for organ preparation in regenerative medicine and establishing novel models for drug development. Confirming that complemented organs and cells work normally in
Externí odkaz:
https://doaj.org/article/83f9324b5cc14be682f2858dae6bd952
Autor:
Kenji Kubara, Kazuto Yamazaki, Yasuharu Ishihara, Takuya Naruto, Huan-Ting Lin, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Masashi Ito, Kappei Tsukahara, Tomohiro Morio, Masatoshi Takagi, Makoto Otsu
Publikováno v:
Stem Cell Reports, Vol 11, Iss 2, Pp 380-394 (2018)
Summary: Oncogenic KRAS mutations in hematopoietic stem cells cause RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD). KRAS plays essential roles in stemness maintenance in some types of stem cells. However, its roles in plur
Externí odkaz:
https://doaj.org/article/bec0e0806fec42e48f4d3ad662e1e2de
Autor:
Kazuto, Yamazaki, Kenji, Kubara, Yuta, Suzuki, Taro, Hihara, Daisuke, Kurotaki, Tomohiko, Tamura, Masashi, Ito, Kappei, Tsukahara
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 183:61-73
Nucleic acid therapeutics have been utilized for gene regulation, and their recent advancement has led to approval of novel drugs for liver-related disorders. However, systemic extrahepatic delivery remains challenging. Here, we report newly designed
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
The list of Topologically significant genes by RNA-Seq analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b281375c38e0afca97059249be1c48
https://doi.org/10.1158/0008-5472.22427412
https://doi.org/10.1158/0008-5472.22427412
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and the development of multiple types of cancer, and its aberrant activation provides cancer cells with escape mechanisms from immune checkpoint inhibitors. E7386, an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df148bb84b7d866ede93b24adb73553f
https://doi.org/10.1158/0008-5472.c.6512661.v1
https://doi.org/10.1158/0008-5472.c.6512661.v1
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
Supplementary Table S1, Table S4, Table S5, Table S6, Table S7. Supplementary Table S1: The list of DEGs by nCounter analysis (|Fold change| > 1.25, P < 0.1). Supplementary Table S4: Top 10 enriched pathways identified by RNA-Seq analysis in MMTV-Wnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f3891dd6ecfe611c8e93caa46647a9
https://doi.org/10.1158/0008-5472.22427409
https://doi.org/10.1158/0008-5472.22427409
Autor:
Yoichi Ozawa, Yasuhiro Funahashi, Takashi Owa, Hiroyuki Kouji, Kenichi Nomoto, Tomohiro Matsushima, Junji Matsui, Toshimitsu Uenaka, Akihiko Tsuruoka, Masao Iwata, Takenao Odagami, Masayuki Matsukura, Akira Yokoi, Taro Semba, Yu Kato, Kenji Kubara, Naomi Wakayama, Ikuo Kushida, Atsushi Takemura, Naoki Yoneda, Hitoshi Harada, Kazutaka Nakamoto, Masahiro Matsuki, Junichi Ito, Mai Uesugi, Takayuki Kimura, Atsumi Yamaguchi, Hiroshi Kamiyama, Kentaro Iso, Yuji Yamamoto, Satoshi Inoue, Yusaku Hori, Kazuhiko Yamada
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837e71997bd46c4dda72ece16272f5ee
https://doi.org/10.1158/0008-5472.22427418.v1
https://doi.org/10.1158/0008-5472.22427418.v1