Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Kenji Kawabata"'
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-10 (2023)
Abstract Background Brain microvascular endothelial cells (BMECs) play a major role in the blood–brain barrier (BBB), and are critical for establishing an in vitro BBB model. Currently, iPSC-derived BMECs (iBMECs) have been used to construct in vit
Externí odkaz:
https://doaj.org/article/2770f4cc566949d2b548b199bddc7cf7
Autor:
Marie Piantino, Fiona Louis, Yukari Shigemoto-Mogami, Kimiko Kitamura, Kaoru Sato, Tomoko Yamaguchi, Kenji Kawabata, Syunsuke Yamamoto, Shinji Iwasaki, Hideki Hirabayashi, Michiya Matsusaki
Publikováno v:
Materials Today Bio, Vol 14, Iss , Pp 100232- (2022)
The blood-brain barrier (BBB), a selective barrier formed by brain microvascular endothelial cells (BMEC), represents a major challenge for the efficient accumulation of pharmaceutical drugs into the brain. The receptor-mediated transcytosis (RMT) ha
Externí odkaz:
https://doaj.org/article/59de46fe30574805a1f2d16bcb8a2d57
Autor:
Eiko Sakai, Yusuke Miura, Emi Suzuki-Kouyama, Kengo Oka, Masashi Tachibana, Kenji Kawabata, Fuminori Sakurai, Hiroyuki Mizuguchi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Angiogenesis, new vessel formation from pre-existing vessels, is a highly conserved event through vertebrates. However, the system for tuning angiogenesis by species-intrinsic factors is totally unknown. miR-1224 is a member of mammal-specif
Externí odkaz:
https://doaj.org/article/bd865baf34144ea8b49fb925209bcf32
Autor:
Tomoko Yamaguchi, Kentaro Shimizu, Yasuhiro Kokubu, Misae Nishijima, Shuko Takeda, Hiroshi Ogura, Kenji Kawabata
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222113 (2019)
The incidence of heatstroke has been increasing. Heatstroke has been shown to affect physiological barrier functions. However, there are few studies of the effect of heat stress on the blood-brain barrier (BBB) function. In this study, we investigate
Externí odkaz:
https://doaj.org/article/c2afb4bc78b943ef8102ad2e2c70a47f
Autor:
Hiroyuki Mizuguchi, Kenji Kawabata, Fuminori Sakurai, Kazufumi Katayama, Mitsuhiro Machitani, Kahori Shimizu, Tomoko Yamaguchi
Publikováno v:
Pharmaceutics, Vol 3, Iss 3, Pp 338-353 (2011)
The major limitation of the clinical use of replication-incompetent adenovirus (Ad) vectors is the interference by innate immune responses, including induction of inflammatory cytokines and interferons (IFN), following in vivo application of Ad vecto
Externí odkaz:
https://doaj.org/article/02b38c0320d0490ba67dec43290044ec
Autor:
Yasuhito Nagamoto, Kazuo Takayama, Katsuhisa Tashiro, Chise Tateno, Fuminori Sakurai, Masashi Tachibana, Kenji Kawabata, Kazuo Ikeda, Yasuhito Tanaka, Hiroyuki Mizuguchi
Publikováno v:
Cell Transplantation, Vol 24 (2015)
Human liver chimeric mice are expected to be applied for drug toxicity tests and human hepatitis virus research. Human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs) are a highly attractive donor source for the generation of
Externí odkaz:
https://doaj.org/article/d8bfbc41b37b4e0ab9fb26b2f6c25c9c
Autor:
Haruka Minami, Katsuhisa Tashiro, Atsumasa Okada, Nobue Hirata, Tomoko Yamaguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Kenji Kawabata
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128890 (2015)
The blood brain barrier (BBB) is formed by brain microvascular endothelial cells (BMECs) and tightly regulates the transport of molecules from blood to neural tissues. In vitro BBB models from human pluripotent stem cell (PSCs)-derived BMECs would be
Externí odkaz:
https://doaj.org/article/26b300e320ba47b1a846c8ec0fddc34f
Autor:
Kahori Shimizu, Fuminori Sakurai, Kyoko Tomita, Yasuhito Nagamoto, Shin-ichiro Nakamura, Kazufumi Katayama, Masashi Tachibana, Kenji Kawabata, Hiroyuki Mizuguchi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Leaky expression of adenovirus (Ad) genes occurs following transduction with a conventional replication-incompetent Ad vector, leading to an induction of cellular immunity against Ad proteins and Ad protein-induced toxicity, especially in the late ph
Externí odkaz:
https://doaj.org/article/0c86e51c8c5d404085002a2e2863ce7e
Autor:
Hitoshi Watanabe, Kazuo Takayama, Mitsuru Inamura, Masashi Tachibana, Natsumi Mimura, Kazufumi Katayama, Katsuhisa Tashiro, Yasuhito Nagamoto, Fuminori Sakurai, Kenji Kawabata, Miho Kusuda Furue, Hiroyuki Mizuguchi
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90791 (2014)
Human embryonic stem cells (hESCs) could provide a major window into human developmental biology, because the differentiation methods from hESCs mimic human embryogenesis. We previously reported that the overexpression of hematopoietically expressed
Externí odkaz:
https://doaj.org/article/ee866b8fe30140fbabcdf0f8d44d0775
Autor:
Kazuo Takayama, Mitsuru Inamura, Kenji Kawabata, Katsuhisa Tashiro, Kazufumi Katayama, Fuminori Sakurai, Takao Hayakawa, Miho Kusuda Furue, Hiroyuki Mizuguchi
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21780 (2011)
The establishment of methods for directive differentiation from human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) is important for regenerative medicine. Although Sry-related HMG box 17 (SOX17) overexpression in ESCs leads
Externí odkaz:
https://doaj.org/article/cb3e985954ad4852a34169f1ae650f91