Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kenji Iemura"'
Autor:
Chihiro Yamada, Aya Morooka, Seira Miyazaki, Masayoshi Nagai, Satoru Mase, Kenji Iemura, Most Naoshia Tasnin, Tsuneyuki Takuma, Shotaro Nakamura, Shamsul Morshed, Naoki Koike, Md. Golam Mostofa, Muhammad Arifur Rahman, Tasnuva Sharmin, Haruko Katsuta, Kotaro Ohara, Kozo Tanaka, Takashi Ushimaru
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103675- (2022)
Summary: Unsatisfied kinetochore-microtubule attachment activates the spindle assembly checkpoint to inhibit the metaphase-anaphase transition. However, some cells eventually override mitotic arrest by mitotic slippage. Here, we show that inactivatio
Externí odkaz:
https://doaj.org/article/1022385d83204cfdbe69989bb4c99062
Publikováno v:
Biomolecules, Vol 9, Iss 1, p 10 (2018)
For appropriate chromosome segregation, kinetochores on sister chromatids have to attach to microtubules from opposite spindle poles (bi-orientation). Chromosome alignment at the spindle equator, referred to as congression, can occur through the atta
Externí odkaz:
https://doaj.org/article/53e8d69355754d82848c55bea13a0f02
Autor:
Go Itoh, Masanori Ikeda, Kenji Iemura, Mohammed Abdullahel Amin, Sei Kuriyama, Masamitsu Tanaka, Natsuki Mizuno, Hiroko Osakada, Tokuko Haraguchi, Kozo Tanaka
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Externí odkaz:
https://doaj.org/article/a688b48b56fc49d089ac16f05d893526
Publikováno v:
Journal of Cell Science.
Chromosomal aneuploidy has been associated with aging. However, whether and how chromosomal instability (CIN), a condition frequently seen in cancer cells in which chromosome missegregation occurs at a high rate, is associated with aging is not fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a04c28b67a6dea1a8fb34ff0623079a
https://doi.org/10.1242/jcs.260688
https://doi.org/10.1242/jcs.260688
Publikováno v:
Cancer Science
Antimitotic drugs such as vinca alkaloids and taxanes cause mitotic cell death after prolonged mitotic arrest. However, a fraction of cells escape from mitotic arrest by undergoing mitotic slippage, which is related to resistance to antimitotic drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d522bf63f97a82a877b5533f81b5f9
http://europepmc.org/articles/PMC8409433
http://europepmc.org/articles/PMC8409433
Autor:
Masayoshi Nagai, Kenji Iemura, Takako Kikkawa, Sharmin Naher, Satoko Hattori, Hideo Hagihara, Koh-ichi Nagata, Hayato Anzawa, Risa Kugisaki, Hideki Wanibuchi, Takaya Abe, Kenichi Inoue, Kengo Kinoshita, Tsuyoshi Miyakawa, Noriko Osumi, Kozo Tanaka
Publikováno v:
Brain Communications. 4
CHAMP1 is a gene associated with intellectual disability, which was originally identified as being involved in the maintenance of kinetochore–microtubule attachment. To explore the neuronal defects caused by CHAMP1 deficiency, we established mice t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc3603a3c2686acdde54877fb06f5c1c
https://doi.org/10.1093/braincomms/fcac220
https://doi.org/10.1093/braincomms/fcac220
Publikováno v:
Biomedical research (Tokyo, Japan). 42(5)
Chromosome oscillation during metaphase is attenuated in cancer cell lines, concomitant with the reduction of Aurora A activity on kinetochores, which results in reduced mitotic fidelity. To verify the correlation between Aurora A activity, chromosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652f69a2cac22396a3be5aeb73dfe427
https://pubmed.ncbi.nlm.nih.gov/34544996
https://pubmed.ncbi.nlm.nih.gov/34544996
Autor:
Norihisa Shindo, Kazuki Kumada, Kenji Iemura, Jun Yasuda, Haruna Fujimori, Mai Mochizuki, Keiichi Tamai, Kozo Tanaka, Toru Hirota
Publikováno v:
Cell Reports. 41:111723
Accurate chromosome segregation requires timely activation of separase, a protease that cleaves cohesin during the metaphase-to-anaphase transition. However, the mechanism that maintains the inactivity of separase prior to this event remains unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd8e0eefdb51e4671c5dd0cd093ff04
https://doi.org/10.1016/j.celrep.2022.111723
https://doi.org/10.1016/j.celrep.2022.111723
Publikováno v:
The Journal of Cell Biology
Iemura et al. find that chromosome oscillation during metaphase facilitates correction of erroneous kinetochore–microtubule attachments through Hec1 phosphorylation by Aurora A on the spindle. Chromosome oscillation is attenuated in cancer cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf4702dbe21ad1f6e1c2d69e0a11399
https://doi.org/10.1083/jcb.202006116
https://doi.org/10.1083/jcb.202006116
Autor:
Chihiro Yamada, Aya Morooka, Seira Miyazaki, Masayoshi Nagai, Satoru Mase, Kenji Iemura, Most Naoshia Tasnin, Tsuneyuki Takuma, Shotaro Nakamura, Shamsul Morshed, Naoki Koike, Md. Golam Mostofa, Muhammad Arifur Rahman, Tasnuva Sharmin, Haruko Katsuta, Kotaro Ohara, Kozo Tanaka, Takashi Ushimaru
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103675-(2022)
Summary: Unsatisfied kinetochore-microtubule attachment activates the spindle assembly checkpoint to inhibit the metaphase-anaphase transition. However, some cells eventually override mitotic arrest by mitotic slippage. Here, we show that inactivatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3530321cd3309363c4c76edccd93d02a
https://pubmed.ncbi.nlm.nih.gov/35141499
https://pubmed.ncbi.nlm.nih.gov/35141499