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A tyrosine‐based YXXΦ motif regulates the degradation of aquaporin‐4 via both lysosomal and proteasomal pathways and is functionally inhibited by a 10‐amino‐acid sequence within its C‐terminus

Autor: Yingqi Wang, Ryosuke Suzuki, Atsushi Fujii, Kenji Ieki, Wakami Goda, Masato Yasui, Yoichiro Abe

Publikováno v: The FEBS Journal. 290:2616-2635

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c05f1c2f464420141ffb805cc55f2dd3
https://doi.org/10.1111/febs.16717

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A tyrosine-based YXXΦ motif regulates the degradation of aquaporin-4 via both lysosomal and proteasomal pathways and is functionally inhibited by a ten-amino-acid sequence within its C-terminus

Autor: Yingqi, Wang, Ryosuke, Suzuki, Atsushi, Fujii, Kenji, Ieki, Wakami, Goda, Masato, Yasui, Yoichiro, Abe

Publikováno v: The FEBS journal.

Aquaporin-4 (AQP4) is a dominant water channel in the brain and is expressed on astrocytic end-feet, mediating water homeostasis in the brain. AQP4 is a target of an inflammatory autoimmune disease, neuromyelitis optica spectrum disorders (NMOSD), th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9aa9788ab96c5ffd7373f70e514bc7e4
https://pubmed.ncbi.nlm.nih.gov/36597763

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