Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Kenji Hosoya"'
Autor:
Yu Asari, Jumpei Yamazaki, Oo Thandar, Tamami Suzuki, Keisuke Aoshima, Kyosuke Takeuchi, Ryohei Kinoshita, Sangho Kim, Kenji Hosoya, Teita Ishizaki, Yumiko Kagawa, Jaroslav Jelinek, Shoko Yokoyama, Noboru Sasaki, Hiroshi Ohta, Kensuke Nakamura, Mitsuyoshi Takiguchi
Publikováno v:
Veterinary Medicine and Science, Vol 9, Iss 5, Pp 2006-2014 (2023)
Abstract Background Canine hepatocellular tumours (HCTs) are common primary liver tumours. However, the exact mechanisms of tumourigenesis remain unclear. Although some genetic mutations have been reported, DNA methylation alterations in canine HCT h
Externí odkaz:
https://doaj.org/article/38abf3d207964d4eb9ee6f06585ecf36
Autor:
Naoya Maekawa, Satoru Konnai, Yumie Asano, Yamato Sajiki, Tatsuya Deguchi, Tomohiro Okagawa, Kei Watari, Hiroto Takeuchi, Satoshi Takagi, Kenji Hosoya, Sangho Kim, Hiroshi Ohta, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Immune checkpoint inhibitors (ICIs) such as anti-PD-L1 antibodies are widely used to treat human cancers, and growing evidence suggests that ICIs are promising treatments for canine malignancies. However, only some canine oral malignant mela
Externí odkaz:
https://doaj.org/article/9195edeb9fe7415f92cb3f8d09b03d7b
Autor:
Naoya Maekawa, Satoru Konnai, Kenji Hosoya, Sangho Kim, Ryohei Kinoshita, Tatsuya Deguchi, Ryo Owaki, Yurika Tachibana, Madoka Yokokawa, Hiroto Takeuchi, Yumiko Kagawa, Satoshi Takagi, Hiroshi Ohta, Yukinari Kato, Satoshi Yamamoto, Keiichi Yamamoto, Yasuhiko Suzuki, Tomohiro Okagawa, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0291727 (2023)
Immune checkpoint inhibitors (ICIs) have been developed for canine tumour treatment, and pilot clinical studies have demonstrated their antitumour efficacy in dogs with oral malignant melanoma (OMM). Although ICIs have been approved for various human
Externí odkaz:
https://doaj.org/article/295c408651194fcf866d2177d2d31e14
Autor:
Mei Sugawara-Suda, Keitaro Morishita, Osamu Ichii, Takashi Namba, Keisuke Aoshima, Yumiko Kagawa, Sangho Kim, Kenji Hosoya, Nozomu Yokoyama, Noboru Sasaki, Kensuke Nakamura, Jumpei Yamazaki, Mitsuyoshi Takiguchi
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285415 (2023)
Precursor-targeted immune-mediated anemia (PIMA) in dogs is characterized by persistent non-regenerative anemia and ineffective erythropoiesis, and it is suspected to be an immune-mediated disease. Most affected dogs respond to immunosuppressive ther
Externí odkaz:
https://doaj.org/article/0bdbbd8efa24441591699f05f1aa13f5
Autor:
Tatsuya Deguchi, Kenji Hosoya, Shango Kim, Yusuke Murase, Kumiko Yamamoto, Tomoki Bo, Hironobu Yasui, Osamu Inanami, Mahiro Okumura
Publikováno v:
Molecular Therapy: Oncolytics, Vol 22, Iss , Pp 143-151 (2021)
Metformin has many anti-cancer effects, alone or in combination with radiation. However, the mechanism underlying its radio-sensitized effect is still unclear, especially for cancer stem-like cells (CSCs). Here, the radio-sensitized effect of metform
Externí odkaz:
https://doaj.org/article/12a605f119294206adcc769a6eac61c1
Publikováno v:
Veterinary Medicine and Science, Vol 7, Iss 4, Pp 1120-1130 (2021)
Abstract Allogeneic hematopoietic cell transplantation (HCT) has been an effective treatment for human patients with haematological malignancies (Baron & Storb, 2006; Bair et al., 2020; Copelan et al., 2019). However, the optimal pretransplant condit
Externí odkaz:
https://doaj.org/article/5c783d8d8e634a2f81f00dd065ee0b3d
Autor:
Naoya Maekawa, Satoru Konnai, Maki Nishimura, Yumiko Kagawa, Satoshi Takagi, Kenji Hosoya, Hiroshi Ohta, Sangho Kim, Tomohiro Okagawa, Yusuke Izumi, Tatsuya Deguchi, Yukinari Kato, Satoshi Yamamoto, Keiichi Yamamoto, Mikihiro Toda, Chie Nakajima, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-9 (2021)
Abstract Immunotherapy targeting programmed cell death 1 (PD-1) and PD-ligand 1 (PD-L1) represents promising treatments for human cancers. Our previous studies demonstrated PD-L1 overexpression in some canine cancers, and suggested the therapeutic po
Externí odkaz:
https://doaj.org/article/33eb1d45a3ba4b309dbca6e1d44f59bf
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Bilomas are encapsulated collections of bile outside or inside the biliary tract within the abdominal cavity. For diagnostic and therapeutic approaches, it is important to identify the origin of bile leaks from the biliary tract. This case report des
Externí odkaz:
https://doaj.org/article/db0a3a5f5d8d44209d54daef54ff15b5
Autor:
H. M. Suranji Wijekoon, Eugene C. Bwalya, Jing Fang, Sangho Kim, Kenji Hosoya, Masahiro Okumura
Publikováno v:
BMC Veterinary Research, Vol 14, Iss 1, Pp 1-8 (2018)
Abstract Background Sodium pentosan polysulfate (NaPPS) was testified as a chondroprotective drug in with a detailed rationale of the disease-modifying activity. This study was undertaken to determine whether anti-osteoarthritis drug, NaPPS inhibited
Externí odkaz:
https://doaj.org/article/8afca8385987406f9d2ccab49096df20
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177144 (2017)
Osteoarthritic (OA) chondrocytes are shown to express inducible nitric oxide synthase (iNOS) which produces high concentrations of nitric oxide (NO), particularly when stimulated with proinflammatory cytokines. NO is involved in OA cartilage degradat
Externí odkaz:
https://doaj.org/article/358d42881ed3497eb65d559a174fdbd8