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Akademický článek

Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice

Autor: Keisuke Migita, Akiko Nishimura, Fumihiro Eto, Kohei Koga, Taichi Matsumoto, Kazuki Terada, Shuji Hara, Kenji Honda

Publikováno v: Journal of Pharmacological Sciences, Vol 142, Iss 2, Pp 50-59 (2020)

Cholinergic neurons play an important role in the higher functions of the brain, such as the memory, cognition, and nociception. However, the exact mechanism behind how the stimulation of all the muscarinic M1 receptors in the entire brain results in

Externí odkaz: https://doaj.org/article/8fcf14684b8b4adda7c2721b6364cbdf

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Akademický článek

Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model

Autor: Keisuke Migita, Yu Matsuzaki, Kohei Koga, Taichi Matsumoto, Kenichi Mishima, Shuji Hara, Kenji Honda

Publikováno v: Journal of Pharmacological Sciences, Vol 137, Iss 2, Pp 233-236 (2018)

The role of the GABAB receptor in the anterior cingulate cortex (ACC) of neuropathic pain is unclear. Injection of a GABAB receptor antagonist CGP35348 into the ACC induced mechanical hypersensitivity in normal rats. Activation of the GABAB receptor

Externí odkaz: https://doaj.org/article/0aab8162f584456880ab49dc09b340de

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Akademický článek

Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats

Autor: Tomoharu Masuda, Yasutoshi Hirabara, Yusuke Nakamura, Akiko Chishaki, Mai Tsuruhisa, Masayuki Miyakawa, Kenji Honda, Ryo Saito, Hirotaka Sakamoto, Mitsuhiro Kawata, Yukio Takano

Publikováno v: Journal of Pharmacological Sciences, Vol 112, Iss 4, Pp 482-486 (2010)

We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium–loaded rats and was signific

Externí odkaz: https://doaj.org/article/5cec4f249f25433fb3d29b1756f4bfbf

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Akademický článek

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects

Autor: Kenji Honda, Yukio Takano

Publikováno v: Journal of Pharmacological Sciences, Vol 109, Iss 1, Pp 38-43 (2009)

Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-recep

Externí odkaz: https://doaj.org/article/a2d2183293454fc5ad70c5513e0a24af

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Akademický článek

The Spinal Muscarinic M1 Receptors and GABAA Receptors Contribute to the McN-A-343–Induced Antinociceptive Effects During Thermal Stimulation of Mice

Autor: Kenji Honda, Keigo Horikawa, Suguru Ando, Kohei Koga, Satoshi Kawata, Keisuke Migita, Yukio Takano

Publikováno v: Journal of Pharmacological Sciences, Vol 108, Iss 4, Pp 472-479 (2008)

The present study was undertaken to clarify how spinal muscarinic receptors are involved in the antinociceptive effects in thermal stimulation. Intrathecal (i.t.) injection of the muscarinic agonist McN-A-343 inhibited the tail-flick response to noxi

Externí odkaz: https://doaj.org/article/d893fb40265545a5a3a4b5d10a7d614b

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Akademický článek

A High-Sodium Diet in Streptozotocin-Induced Diabetic Rats Impairs Endothelium-Derived Hyperpolarizing Factor-Mediated Vasodilation

Autor: Yasutoshi Hirabara, Mina Araki, Mio Fukuda, Shiori Katafuchi, Kenji Honda, Ryo Saito, Yukio Takano

Publikováno v: Journal of Pharmacological Sciences, Vol 104, Iss 4, Pp 402-405 (2007)

We examined endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of mesenteric arteries in high-sodium loaded streptozotocin (STZ)-induced diabetic rats. The study shows that acetylcholine (ACh)-induced, EDHF-mediated relaxation is r

Externí odkaz: https://doaj.org/article/96a99f2e7d0c497f94dcf65cfb233e8b

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Autor: Akiko Nishimura, Keisuke Migita, Kenji Honda, Shuji Hara, Taichi Matsumoto, Fumihiro Eto, Kazuki Terada, Kohei Koga

Publikováno v: Journal of Pharmacological Sciences, Vol 142, Iss 2, Pp 50-59 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8495400ba8a14a1bc30164b5eb82b16f
http://www.sciencedirect.com/science/article/pii/S1347861319341751

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Synthesis of siRNAs incorporated with cationic peptides R8G7 and R8A7 and the effect of the modifications on siRNA properties

Autor: Koki Ozaki, Miho Matsubara, Yusuke Maeda, Yoshihito Ueno, Yuri Kakisawa, Kenji Honda, Ryohei Kajino

Publikováno v: RSC Advances. 10:34815-34824

Small interfering RNA (siRNA) can be used as an innovative next-generation drug. However, there are several challenges in the therapeutic application of siRNAs, including their low cell membrane permeability. In this study, we designed and synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04eba7f2674e619d5d6dc745bb6a1cf
https://doi.org/10.1039/d0ra05919f

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