Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kenji Handa"'
Autor:
Naoko Ohshita, Anna Tajima, Taishi Higashi, Keiichi Motoyama, Sawako Koyama, Ruriko Iibuchi, Shiuhei Mieda, Kenji Handa, Tomoaki Kimoto, Hidetoshi Arima
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 11, Iss 1, Pp 221-222 (2016)
Externí odkaz:
https://doaj.org/article/c8399d2938e248a3b57ab40a7ea776e7
Publikováno v:
Journal of Pharmaceutical Sciences. 104:2457-2463
The stabilization of antibodies in aqueous solution against physical stress remains a problematic issue for pharmaceutical applications. Recently, protein-polyelectrolyte complex (PPC) formation using poly(amino acids) was proposed to prepare antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d8144acfa6c1018867fcfb6b89f10e
https://doi.org/10.1002/jps.24515
https://doi.org/10.1002/jps.24515
Autor:
Izaki Shunsuke, Tomoaki Kimoto, Takaaki Kurinomaru, Takuya Maruyama, Takayuki Uchida, Kentaro Shiraki, Kenji Handa
Publikováno v:
Journal of pharmaceutical sciences. 104(6):1929-1937
Development of high-concentration antibody formulations for subcutaneous administration remains challenging. Recently, a precipitation-redissolution method was proposed to prepare suspensions or precipitates of salt-dissociable protein-poly(amino aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c641e03cdf72e44fd1d5550a1b20c20f
https://tsukuba.repo.nii.ac.jp/records/34571
https://tsukuba.repo.nii.ac.jp/records/34571
Autor:
Tomoaki Kimoto, Kenji Handa, Takuya Maruyama, Izaki Shunsuke, Kentaro Shiraki, Takaaki Kurinomaru
Publikováno v:
Journal of Pharmaceutical Sciences. 103:2248-2254
A method for concentration of protein solutions is required for high-dosage protein formulation. Here, we present a precipitation–redissolution method by poly(amino acid) for proteins, including therapeutic enzymes, antibodies, and hormones. The pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f609d55408a93f540205c9486ab27cf
https://doi.org/10.1002/jps.24025
https://doi.org/10.1002/jps.24025
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 167:65-73
Peptidylarginine deiminase (PAD; EC 3.5.3.15) is a post-translational modification enzyme that catalyzes the conversion of protein-bound arginine to citrulline (deimination) in a calcium ion dependent manner. Although PADI genes are widely conserved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75419e6297cbf790acc3492611e7b813
https://doi.org/10.1016/j.cbpb.2013.10.003
https://doi.org/10.1016/j.cbpb.2013.10.003
Autor:
Shiuhei Mieda, Tomoaki Kimoto, Taishi Higashi, Ruriko Iibuchi, Naoko Ohshita, Yoshihito Yamashita, Keiichi Motoyama, Sawako Koyama, Tatsunori Hirotsu, Takayuki Uchida, Hidetoshi Arima, Kenji Handa
Publikováno v:
Journal of pharmaceutical sciences. 106(5)
Antibodies often have poor physicochemical stability during storage and transport, which is a serious drawback for the development of antibody-based drugs. In this study, we prepared polypseudorotaxane (PPRX) hydrogels consisting of cyclodextrins (Cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38aa5379803c09932d9f1484ebc7462a
https://pubmed.ncbi.nlm.nih.gov/28089687
https://pubmed.ncbi.nlm.nih.gov/28089687
Autor:
Kenji Handa
Publikováno v:
Journal of Functional Analysis. 262(10):4488-4524
Continuous state branching processes with immigration are studied. We are particularly concerned with the associated (non-symmetric) Dirichlet form. After observing that gamma distributions are only reversible distributions for this class of models,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcc74c9a975d1b79eb698061be9794f
Autor:
Shiuhei Mieda, Irhan Ibrahim Abu Hashim, Keiichi Motoyama, Taishi Higashi, Kenji Handa, Naoko Ohshita, Hidetoshi Arima, Anna Tajima, Ruriko Iibuchi, Tatsunori Hirotsu, Sawako Koyama, Tomoaki Kimoto
To achieve the potent therapeutic effects of human immunoglobulin G (IgG), highly concentrated formulations are required. However, the stabilization for highly concentrated human IgG is laborious work. In the present study, to investigate the potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25aacd840e653be3a7cbffd755cdb6f
https://europepmc.org/articles/PMC4666269/
https://europepmc.org/articles/PMC4666269/
Autor:
Takuya Maruyama, Takaaki Kurinomaru, Kenji Handa, Izaki Shunsuke, Kentaro Shiraki, Tomoaki Kimoto
Publikováno v:
Journal of bioscience and bioengineering. 120(6)
Long-term storage in aqueous solution has been demanded for the practical application of therapeutic proteins. Recently, a precipitation-redissolution method was proposed to prepare salt-dissociable protein-polyelectrolyte complex (PPC). To elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907f0f358427df34f79d126790cb1e71
https://pubmed.ncbi.nlm.nih.gov/25979123
https://pubmed.ncbi.nlm.nih.gov/25979123
Autor:
Kenji Handa
Publikováno v:
Annales de l?Institut Henri Poincare (B) Probability and Statistics. 40:569-597
We consider multi-allelic Gillespie–Sato diffusion models in population genetics. The case where they have reversible distributions is completely determined in terms of mutation rates and selection intensity. In such cases we give an explicit expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c157a614b4e4bc456e0db8c3552991cd
https://doi.org/10.1016/j.anihpb.2003.08.002
https://doi.org/10.1016/j.anihpb.2003.08.002