Zobrazeno 1 - 10
of 548
pro vyhledávání: '"Kenji FUJIWARA"'
Autor:
Kenji Fujiwara, Yingkuan Shao, Nan Niu, Tengyi Zhang, Brian Herbst, Mackenzie Henderson, Stephen Muth, Pingbo Zhang, Lei Zheng
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract Background Identifying T cell epitopes on pancreatic ductal adenocarcinoma (PDAC) associated antigens or neoantigens has been a challenge. In this study, we attempted to identify PDAC T cell epitopes by mass spectrometry (MS). Methods We iso
Externí odkaz:
https://doaj.org/article/55e292b387044fd2aed850ced5ae6fdc
Autor:
Tao Xia, Keyu Li, Nan Niu, Yingkuan Shao, Ding Ding, Dwayne L. Thomas, Hao Jing, Kenji Fujiwara, Haijie Hu, Arsen Osipov, Chunhui Yuan, Christopher L. Wolfgang, Elizabeth D. Thompson, Robert A. Anders, Jin He, Yiping Mou, Adrian G. Murphy, Lei Zheng
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-20 (2022)
Abstract Background Immunotherapy has demonstrated a limited clinical efficacy in approximately 5% of cholangiocarcinoma. The main challenges for an effective immunotherapy response in cholangiocarcinoma arise from the tumor microenvironment, which i
Externí odkaz:
https://doaj.org/article/0811bea100fd47df96bb43572ac97480
Autor:
Xingyi Pan, Jiaojiao Zhou, Qian Xiao, Kenji Fujiwara, Mengwen Zhang, Guanglan Mo, Wei Gong, Lei Zheng
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Background Metastasis occurs in the majority of pancreatic ductal adenocarcinoma (PDAC) patients at diagnosis or following resection. Patients with liver metastasis and those with lung metastasis have significantly different prognosis. Here,
Externí odkaz:
https://doaj.org/article/f238506938f847eba77d51ab06e86993
Autor:
Mengwen Zhang, Xingyi Pan, Kenji Fujiwara, Noelle Jurcak, Stephen Muth, Jiaojiao Zhou, Qian Xiao, Anqi Li, Xu Che, Zihai Li, Lei Zheng
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-18 (2021)
Abstract How tumor-associated macrophages transit from a predominant antitumor M1-like phenotype to a protumoral M2-like phenotype during the development of pancreatic ductal adenocarcinoma (PDA) remains to be elucidated. We thus conducted a study by
Externí odkaz:
https://doaj.org/article/f44476e767304cb8ba676a3ef47fb2bb
Autor:
Kenji Fujiwara, Atsushi Abe, Toshihiro Masatsugu, Tatsuya Hirano, Kiyohisa Hiraka, Masayuki Sada
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255253 (2021)
BackgroundThe preoperative distinction between uncomplicated and complicated appendicitis is important to determine the appropriate treatments, such as antibiotics, surgery, or interval appendectomy. Computed tomography (CT) plays an important role;
Externí odkaz:
https://doaj.org/article/066ec7d855944f358ad85ca1fb1dec15
Autor:
Ding Ding, Linda Chen, Lei Zheng, May Tun Saung, Stephen Muth, Kenji Fujiwara, Hao Jing, Brian Herbst, MacKenzie Zarecki, Annie Wu, Elaine Bigelow, Keyu Li, Neolle Jurcak, Alex B Blair, Michael Wichroski, Jordan Blum, Nathan Cheadle, Jennifer Koenitzer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Radiation therapy (RT) has the potential to enhance the efficacy of immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape of treatments for many cancers, but not yet for pancreatic ductal adenocarcinoma
Externí odkaz:
https://doaj.org/article/468e45316311472f8fc837a650b30475
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239178 (2020)
BackgroundUnexpected gallbladder cancer (UGBC) is sometimes found in the resected gallbladder of patients during or after surgery. Some reports have indicated UGBC identification rates for all gallbladder surgeries, but scarce data are available for
Externí odkaz:
https://doaj.org/article/94666029d76f45e08d87fc3b1230e9d4
Autor:
Kenji Fujiwara, Kenoki Ohuchida, Masafumi Sada, Kohei Horioka, Charles D Ulrich, Koji Shindo, Takao Ohtsuka, Shunichi Takahata, Kazuhiro Mizumoto, Yoshinao Oda, Masao Tanaka
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107247 (2014)
CD166, also known as activated leukocyte cell adhesion molecule (ALCAM), is expressed by various cells in several tissues including cancer. However, the role of CD166 in malignant tumors is controversial, especially in pancreatic cancer. This study a
Externí odkaz:
https://doaj.org/article/3947831f81ab467b80ad5f9af05deaa7
Autor:
Kenji Fujiwara, Kenoki Ohuchida, Kazuhiro Mizumoto, Koji Shindo, Daiki Eguchi, Shingo Kozono, Naoki Ikenaga, Takao Ohtsuka, Shunichi Takahata, Shinichi Aishima, Masao Tanaka
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52682 (2012)
Pancreatic stellate cells (PSCs) play a crucial role in the aggressive behavior of pancreatic cancer. Although heterogeneity of PSCs has been identified, the functional differences remain unclear. We characterized CD271⁺ PSCs in human pancreatic ca
Externí odkaz:
https://doaj.org/article/f67cac925d454fa889a076a703234b1b
Autor:
Naoki Ikenaga, Kenoki Ohuchida, Kazuhiro Mizumoto, Shin Akagawa, Kenji Fujiwara, Daiki Eguchi, Shingo Kozono, Takao Ohtsuka, Shunichi Takahata, Masao Tanaka
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40434 (2012)
BACKGROUND: Extracellular matrix (ECM) remodeling is predominantly mediated by fibroblasts using intracellular and extracellular pathways. Although it is well known that extracellular degradation of the ECM by proteases derived from cancer cells faci
Externí odkaz:
https://doaj.org/article/7a3d1b6adae6451bb02c8a95d9f912ad