Výsledky vyhledávání - "Kenji C. Nishihara"

Structure−Activity Relationship Study on a Simple Cationic Peptide Motif for Cellular Delivery of Antisense Peptide Nucleic Acid

Autor: Kenji C Nishihara, Klaus Albertshofer, Brett P. Monia, Eric E. Swayze, Martin Maier, Leila Malik, Andrew M. Siwkowski, C. Frank Bennett, Anne B. Eldrup, Edward Wancewicz, Garth A. Kinberger, Richard S. Geary, Christine Esau, Richard H. Griffey, Muthiah Manoharan, Tanya Watanabe

Publikováno v: Journal of Medicinal Chemistry. 48:6741-6749

Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of peptide nucleic acids (PNAs) as antisense therapeutics. Recently, we reported the identification and functional characterizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99435f07c1247e482294ae1976ff9413
https://doi.org/10.1021/jm050490b

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Dose response of RU486 in a novel rabbit model of noninfectious preterm birth: Comparative efficacy of 3 routes of administration

Autor: Kay D. Beharry, Tamerou Asrat, Kenji C. Nishihara, Joshua Waltzman, Eileen Chang, David Gorenberg, Aamir Akmal

Publikováno v: American Journal of Obstetrics and Gynecology. 192:924-931

Objective The purpose of this study was to examine whether the pregnant rabbit model can be used as a viable model for the study of non–infection-mediated preterm birth. Study design Timed pregnant New Zealand rabbits were injected with a single do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4bba9f76c666d57b41780a559b331b
https://doi.org/10.1016/j.ajog.2004.11.061

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Response of fetal prostanoids, nitric oxide, and ductus arteriosus to the short- and long-term antenatal administration of celecoxib, a selective cyclo-oxygenase-2 inhibitor, in the pregnant rabbit

Autor: Nicole Hausman, Kay D. Beharry, Kenji C. Nishihara, Yasir Akmal, Tamerou Asrat, Yuri Stavitsky

Publikováno v: American Journal of Obstetrics and Gynecology. 189:1744-1750

Objective The purpose of this study was to test the hypothesis that the maternal administration of therapeutic doses of celecoxib would not affect ductus arteriosus patency or alter renal and hepatic prostanoids in the fetal rabbit. Study design Preg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540de72020d3b88eed594fbcd218db04
https://doi.org/10.1016/s0002-9378(03)00831-7

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Early postnatal dexamethasone influences matrix metalloproteinase-2 and -9, and their tissue inhibitors in the developing rat lung

Autor: Kay D. Beharry, Kamakshi Devarajan, Eileen Chang, Jorge G. Ang, Kenji C. Nishihara, Maria A. Abrantes, Houchang D. Modanlou, Joshua Waltzman, Arwin M. Valencia, Richard Van Woerkom

Publikováno v: Pediatric Pulmonology. 35:456-462

In order to test the hypothesis that early postnatal exposure to dexamethasone (Dex) influences matrix metalloproteinases (MMP)-2 and -9, as well as their tissue inhibitors (TIMP-1 and -2) in the developing rat lung, newborn rats (3 litters/group) we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4095148ca93e1c552e3cdec1e7f0b988
https://doi.org/10.1002/ppul.10293

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Effect of the antenatal administration of celecoxib during the second and third trimesters of pregnancy on prostaglandin, cytokine, and nitric oxide levels in rabbits

Autor: Kay D. Beharry, Tamerou Asrat, Kenji C. Nishihara, Nicole Hausman, Yasir Akmal

Publikováno v: American journal of obstetrics and gynecology. 189(6)

Objective The purpose of this study was to examine the effects of celecoxib on prostaglandin, cytokine, and nitric oxide synthesis in the pregnant rabbit. Study design Pregnant rabbits received celecoxib from 13 to 20 days (celecoxib-A), from 13 to 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc438e3b6c9860eec49bf4633c3d98a
https://pubmed.ncbi.nlm.nih.gov/14710107

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Antenatal administration of celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, appears to improve placental perfusion in the pregnant rabbit

Autor: Kay D. Beharry, Tamerou Asrat, Nicole Hausman, Yasir Akmal, Kenji C. Nishihara

Publikováno v: Prostaglandinsother lipid mediators. 70(3-4)

To investigate the effects of celecoxib on fetal growth, and placental prostanoid and nitric oxide (NO) production in fetal rabbits, pregnant rabbits received celecoxib (30 mg/kg per day) from 13 to 20 days (Cel-A), from 13 to 28 days (Cel-B), or veh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f363b28f7f59e32c7efa7bb0575f47b
https://pubmed.ncbi.nlm.nih.gov/12611495

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Differential regulation of prostacyclin and thromboxane by dexamethasone and celecoxib during oxidative stress in newborn rabbits

Autor: Jorge G. Ang, Naomi K. Ozaki, Houchang D. Modanlou, Yasir Akmal, Kay D. Beharry, Kenji C. Nishihara

Publikováno v: Prostaglandinsother lipid mediators. 70(1-2)

To compare the effects of dexamethasone (Dex) and celecoxib (Cel) on F-isoprostane, prostacyclin (PGI 2 ), and thromboxane A 2 (TxA 2 ) following hyperoxia, and hyperoxia followed by recovery in room air (RA), newborn rabbits were exposed to hyperoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051401a05db1f1b60950b8c0f131553b
https://pubmed.ncbi.nlm.nih.gov/12428679

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Regulation of matrix metalloproteinases (type IV collagenases) and their inhibitors in the virgin, timed pregnant, and postpartum rat uterus and cervix by prostaglandin E(2)-cyclic adenosine monophosphate

Autor: Z.Yuelan Ren, Cecilia A. Lyons, Eileen Chang, Yasir Akmal, Kay Beharry, Michael P. Nageotte, Kenji C. Nishihara

Publikováno v: American journal of obstetrics and gynecology. 187(1)

Objective: Our purpose was to examine whether the type IV collagenases (metalloproteinase [MMP]-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) are regulated by a prostaglandin E 2 (PGE 2 )-cyclic adenosine monophosphate (cAMP) mechanism in non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af69fa2b019814f6ea10a61dcd798fd0
https://pubmed.ncbi.nlm.nih.gov/12114911

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Regulation of retinal vascular endothelial growth factor and receptors in rabbits exposed to hyperoxia

Autor: Naomi K, Ozaki, Kay D, Beharry, Kenji C, Nishihara, Yasir, Akmal, Jorge G, Ang, Rizwan, Sheikh, Houchang D, Modanlou

Publikováno v: Investigative ophthalmologyvisual science. 43(5)

To evaluate the molecular responses of vascular endothelial growth factor (VEGF) and its receptors to dexamethasone (Dex) and celecoxib (Cel) during hyperoxia and during hyperoxia followed by recovery in room air, in newborn rabbit retinas.Newborn ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dddf21e138ba66f6d8511c26856dc53e
https://pubmed.ncbi.nlm.nih.gov/11980873

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Nitric oxide/cyclic guanosine 3,5 monophosphate response to cyclooxygenase (COX)-2 inhibition in a rabbit model of RU486-induced preterm birth

Autor: Kay D. Beharry, Tamerou Asrat, Aamir Akmal, Joshua Waltzman, Kenji C. Nishihara, David Gorenberg

Publikováno v: American Journal of Obstetrics and Gynecology. 189:S68

RESPONSE TO CYCLOOXYGENASE (COX)-2 INHIBITION IN A RABBIT MODEL OF RU486-INDUCED PRETERM BIRTH DAVID GORENBERG, KAY BEHARRY, AAMIR AKMAL, KENJI NISHIHARA, JOSHUA WALTZMAN, TAMEROU ASRAT, University of California, Irvine, Obstetrics and Gynecology, Or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e313b00c60152d910c5e07f37f25d3f6
https://doi.org/10.1016/j.ajog.2003.10.029

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