Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Kenji, Takamori"'
Autor:
Yayoi Kamata, Rui Kato, Mitsutoshi Tominaga, Sumika Toyama, Eriko Komiya, Jun Utsumi, Takahide Kaneko, Yasushi Suga, Kenji Takamori
Publikováno v:
JID Innovations, Vol 4, Iss 3, Pp 100271- (2024)
Hand–foot skin reaction is the most common adverse event of multikinase inhibitors, such as sorafenib. Although hand–foot skin reaction is not life threatening, severe cases impair quality of life because of pain and reduced activities of daily l
Externí odkaz:
https://doaj.org/article/45cf325b1bba460da158e3e70b09afd7
Autor:
Go Kojima, Eriko Komiya, Kotaro Honda, Takahide Kaneko, Yasushi Suga, Mitsutoshi Tominaga, Kenji Takamori
Publikováno v:
Acta Dermato-Venereologica, Vol 104 (2024)
Pruritus in the elderly, particularly those cases without skin dryness or other identifiable causes, makes treatment challenging due to the lack of evidence regarding the therapeutic effects of antipruritics. This study proposes an age-related allokn
Externí odkaz:
https://doaj.org/article/7fa17eeafc314878910b92b54de4ad09
Autor:
Qiaofeng Zhao, Mitsutoshi Tominaga, Sumika Toyama, Eriko Komiya, Tomohiro Tobita, Motoki Morita, Ying Zuo, Kotaro Honda, Yayoi Kamata, Kenji Takamori
Publikováno v:
Acta Dermato-Venereologica, Vol 104 (2024)
Atopic dermatitis (AD), a chronic inflammatory skin disease, manifests as an intractable itch. Psychological stress has been suggested to play a role in the onset and worsening of AD symptoms. However, the pathophysiological relationships between psy
Externí odkaz:
https://doaj.org/article/22d074d09fbf4f9380523404222d484f
Autor:
Mitsutoshi Tominaga, Kenji Takamori
Publikováno v:
Allergology International, Vol 71, Iss 3, Pp 265-277 (2022)
Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction, resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic dermatitis is thought to be initiated by a lowering of the itch threshold d
Externí odkaz:
https://doaj.org/article/a67e50b1a1ef43acae471a7f43a5d7ab
Autor:
Ge Peng, Saya Tsukamoto, Risa Ikutama, Hai Le Thanh Nguyen, Yoshie Umehara, Juan V. Trujillo-Paez, Hainan Yue, Miho Takahashi, Takasuke Ogawa, Ryoma Kishi, Mitsutoshi Tominaga, Kenji Takamori, Jiro Kitaura, Shun Kageyama, Masaaki Komatsu, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, François Niyonsaba
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
Human β-defensin-3 (hBD-3) exhibits antimicrobial and immunomodulatory activities; however, its contribution to autophagy regulation remains unclear, and the role of autophagy in the regulation of the epidermal barrier in atopic dermatitis (AD) is p
Externí odkaz:
https://doaj.org/article/730aa69b1d874b99b25b902f4ecf9b79
Autor:
Ryoma Kishi, Sumika Toyama, Mitsutoshi Tominaga, Yayoi Kamata, Eriko Komiya, Takahide Kaneko, Yasushi Suga, Kenji Takamori
Publikováno v:
Cells, Vol 12, Iss 2, p 239 (2023)
Dupilumab attenuates itch and skin inflammation in patients with atopic dermatitis (AD). However, itch-related events that are improved by dupilumab remain unclear. Therefore, the present study investigated changes in clinical scores, serum biomarker
Externí odkaz:
https://doaj.org/article/1647931c8a204953a555f62055a22f0b
Publikováno v:
Cells, Vol 11, Iss 23, p 3930 (2022)
Skin and gut microbiota play an important role in the pathogenesis of atopic dermatitis (AD). An alteration of the microbiota diversity modulates the development and course of AD, e.g., decreased microbiome diversity correlates with disease severity,
Externí odkaz:
https://doaj.org/article/a9fe0428bbe4430797ffce5993b060b6
Autor:
Sanae Inokuchi-Sakata, Yozo Ishiuji, Michie Katsuta, Budiman Kharma, Ken-ichi Yasuda, Mitsutoshi Tominaga, Kenji Takamori, Yoshimasa Nobeyama, Akihiko Asahina
Publikováno v:
Acta Dermato-Venereologica, Vol 101, Iss 7, p adv00491 (2021)
The aim of this study is to elucidate the relationship between 2 different types of severity-indicating parameters (i.e. between subjective and objective severity-indicating parametersin patients with atopic dermatitis. The disease severity of 55 pat
Externí odkaz:
https://doaj.org/article/3a0402fe224d4658bd30abc43ac673fa
Autor:
Noriko Yokoyama, Yeon‐Jeong Kim, Yoshio Hirabayashi, Yoko Tabe, Kenji Takamori, Hideoki Ogawa, Kazuhisa Iwabuchi
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 7, Pp 435-449 (2019)
Abstract Wild‐type Kras, a small GTPase, inactivates Ras growth‐promoting signaling. However, the role of Kras in differentiation of myeloid cells remains unclear. This study showed the involvement of Kras in a novel regulatory mechanism underlyi
Externí odkaz:
https://doaj.org/article/a5dea85e689d4771ac887ad82b915e25
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1022 (2022)
Itch (or pruritus) is an unpleasant sensation, inducing the desire to scratch. It is also a major and distressing symptom of many skin and systemic diseases. The involvement of histamine, which is a major itch mediator, has been extensively examined.
Externí odkaz:
https://doaj.org/article/c33e3cfcd36f4679a40b787ee392fbe6