Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Kenji, Nakahara"'
Autor:
Takuya Oguma, Shota Uehara, Kenji Nakahara, Yuya Okuyama, Kouki Fuchino, Naoyuki Suzuki, Yukiko Kan, Naoki Kanegawa, Yuki Ogata, Ken-ichi Kusakabe
Publikováno v:
ACS Medicinal Chemistry Letters. 14:223-228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::848e8543394668e043b824773e99c23d
https://doi.org/10.1021/acsmedchemlett.2c00427
https://doi.org/10.1021/acsmedchemlett.2c00427
Autor:
Bianca Maria Maglia Orlandi, Omar Asdrúbal Vilca Mejia, Gabrielle Barbosa Borgomoni, Maxim Goncharov, Kenji Nakahara Rocha, Lucas Bassolli, Pedro Gabriel Melo de Barros E Silva, Marcelo Arruda Nakazone, Alexandre Sousa, Valquíria Pelisser Campagnucci, Karlos Alexandre de Sousa Vilarinho, Marcelo Katz, Marcos Gradim Tiveron, Magaly Arrais Dos Santos, Luiz Augusto Ferreira Lisboa, Luis Alberto de Oliveira Dallan, Fábio Biscegli Jatene, REPLICCAR II Study Group
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0223343 (2020)
The quality of data in electronic healthcare databases is a critical component when used for research and health practice. The aim of the present study was to assess the data quality in the Paulista Cardiovascular Surgery Registry II (REPLICCAR II) u
Externí odkaz:
https://doaj.org/article/53b5514958404d28b5ff86e7348c6d72
Autor:
Yuto Unoh, Shota Uehara, Kenji Nakahara, Haruaki Nobori, Yukiko Yamatsu, Shiho Yamamoto, Yuki Maruyama, Yoshiyuki Taoda, Koji Kasamatsu, Takahiro Suto, Kensuke Kouki, Atsufumi Nakahashi, Sho Kawashima, Takao Sanaki, Shinsuke Toba, Kentaro Uemura, Tohru Mizutare, Shigeru Ando, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Takafumi Sato, Teruhisa Kato, Yuki Tachibana
Publikováno v:
Journal of Medicinal Chemistry. 65:6499-6512
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Despite the rapid global spread of COVID-19 vaccines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda3f19d8c44fa9a7e86dcee58fa2330
https://doi.org/10.1021/acs.jmedchem.2c00117
https://doi.org/10.1021/acs.jmedchem.2c00117
Publikováno v:
Journal of the Japan Society of Powder and Powder Metallurgy. 68:175-181
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0628331b9f0a9553746d8c71844d2e6
https://doi.org/10.2497/jjspm.68.175
https://doi.org/10.2497/jjspm.68.175
Autor:
Kenji Nakahara, Hiromichi Fujioka
Publikováno v:
Symmetry, Vol 2, Iss 2, Pp 437-454 (2010)
The desymmetrization of symmetric compounds is a useful approach to obtain chiral building blocks. Readily available precursors with a prochiral unit could be converted into complex molecules with multiple stereogenic centers in a single step. In thi
Externí odkaz:
https://doaj.org/article/1978ff5361cd4827b48e9f5761d419a0
Autor:
Yasuyoshi Iso, Shigeru Ando, Harrie J.M. Gijsen, Yasuto Kido, Shinji Suzuki, Herman Borghys, Kenji Morimoto, Vijay Urmaliya, Deborah Dhuyvetter, Takahiko Yamamoto, Ard Teisman, Gaku Sakaguchi, Naoki Kanegawa, Nigel Austin, Eriko Matsuoka, An Van Den Bergh, Hisanori Ito, Takuya Oguma, Francois Paul Bischoff, Tamio Fukushima, Peter Verboven, Tomoyuki Kawachi, Kenji Nakahara, Yoshinori Yamano, Kosuke Anan, Ken-ichi Kusakabe
Publikováno v:
ChemMedChem. 14:1894-1910
The β-site amyloid precursor protein cleaving enzyme 1 (BACE1, also known as β-secretase) is a promising target for the treatment of Alzheimer's disease. A pKa lowering approach over the initial leads was adopted to mitigate hERG inhibition and P-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985639c1cf0555b69c371d024a0d30ea
https://doi.org/10.1002/cmdc.201900478
https://doi.org/10.1002/cmdc.201900478
Autor:
Kenji Nakahara, Yasuto Kido, Ken-ichi Kusakabe, Satoshi Kasuya, Yasunori Mitsuoka, Takahiko Yamamoto, Shiho Yamamoto, Hisanori Ito
Publikováno v:
European journal of medicinal chemistry. 216
β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) has been pursued as a prime target for the treatment of Alzheimer's disease (AD). In this report, we describe the discovery of BACE1 inhibitors with a 1-amino-3,4-dihydro-2,6-naphthyridine s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac6d8473813c8a87d5e7104b3c2e950
https://pubmed.ncbi.nlm.nih.gov/33765486
https://pubmed.ncbi.nlm.nih.gov/33765486
Autor:
Takahiko Yamamoto, Yasuyoshi Iso, Harrie J.M. Gijsen, Tsuyoshi Hasegawa, Tamio Fukushima, Hisanori Ito, Yoshinori Yamano, Ken-ichi Kusakabe, Yasuto Kido, Herman Borghys, Motoko Hosono, Kenji Nakahara, Kouki Fuchino, Yusuke Sako, Shigeru Ando, Naoya Asada, Kazuo Komano, Gaku Sakaguchi, Masayoshi Ogawa, Genta Tadano, Chie Unemura, Deborah Dhuyvetter, Shuichi Ohnishi
Publikováno v:
Journal of Medicinal Chemistry. 61:5525-5546
β-Secretase (BACE1) has an essential role in the production of amyloid β peptides that accumulate in patients with Alzheimer's disease (AD). Thus, inhibition of BACE1 is considered to be a disease-modifying approach for the treatment of AD. Our hit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0eb137cc2598ec1e3a70b4ec315dc2
https://doi.org/10.1021/acs.jmedchem.8b00011
https://doi.org/10.1021/acs.jmedchem.8b00011
Akademický článek
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Autor:
Yasuyoshi Iso, Naoki Kanegawa, Vijay Urmaliya, Kazuki Fujimoto, Kazuo Komano, Ard Teisman, An Van Den Bergh, Herman Borghys, Hisanori Ito, Shuhei Yoshida, Shigeru Ando, Yasuto Kido, Nigel E. Austin, Naoya Asada, Shinji Suzuki, Kenji Nakahara, Ken-ichi Kusakabe, Eriko Matsuoka, Harrie J.M. Gijsen, Gaku Sakaguchi, Genta Tadano, Yoshinori Yamano, Tamio Fukushima, Takahiko Yamamoto, Deborah Dhuyvetter, Kouki Fuchino
Publikováno v:
Journal of medicinal chemistry. 62(20)
Genetic evidence points to deposition of amyloid-β (Aβ) as a causal factor for Alzheimer's disease. Aβ generation is initiated when β-secretase (BACE1) cleaves the amyloid precursor protein. Starting with an oxazine lead 1, we describe the discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57fbfca1a3d2a869316fa567c087260
https://pubmed.ncbi.nlm.nih.gov/31549838
https://pubmed.ncbi.nlm.nih.gov/31549838