Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kenishana Simpson"'
Autor:
Lisa Sevenich, Stephanie M. Pyonteck, Surajit Dhara, Leila Akkari, Florian Klemm, Kenishana Simpson, Viviane Tabar, Daniela F. Quail, Johanna A. Joyce, Christine A. Iacobuzio-Donahue, Cameron Brennan, Eric E. Gardner, Robert L. Bowman, Philip H. Gutin
Publikováno v:
Cell reports, vol. 17, no. 9, pp. 2445-2459
SummaryExtensive transcriptional and ontogenetic diversity exists among normal tissue-resident macrophages, with unique transcriptional profiles endowing the cells with tissue-specific functions. However, it is unknown whether the origins of differen
Autor:
Karen E. Hunter, Jemila C. Kester, Carmela Palermo, Kenishana Simpson, Laura H. Tang, David S. Klimstra, Jin-Ping Li, Johanna A. Joyce, Israel Vlodavsky
Publikováno v:
Oncogene. 33:1799-1808
Heparan sulfate proteoglycans are an important and abundant component of the extracellular matrix, which undergo substantial remodeling throughout tumorigenesis via the enzymatic activity of heparanase. Heparanase has been shown to be upregulated in
Autor:
Jemila C. Kester, Emily C. Zabor, Tanaya Shree, Kenishana Simpson, Benelita T. Elie, Oakley C. Olson, Katherine M. Bell-McGuinn, Johanna A. Joyce, Alfred L. Garfall, Edi Brogi
Publikováno v:
Genesdevelopment. 25(23)
The microenvironment is known to critically modulate tumor progression, yet its role in regulating treatment response is poorly understood. Here we found increased macrophage infiltration and cathepsin protease levels in mammary tumors following pacl