Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kenisha Arthur"'
Autor:
Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phosphorylase (MTAP) deletion has been proposed as a vulnerability for PRMT5-targeted therapy in cancer. Here, the authors show that MTA does not accumula
Externí odkaz:
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
Autor:
Sunada Khadka, Kenisha Arthur, Yasaman Barekatain, Eliot Behr, Mykia Washington, Jeffrey Ackroyd, Kaitlyn Crowley, Pornpa Suriyamongkol, Yu-Hsi Lin, Cong-Dat Pham, Rafal Zielinski, Marissa Trujillo, James Galligan, Dimitra K. Georgiou, John Asara, Florian Muller
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Background Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating cancer cells. In tumors, the tricarboxylic acid (TCA) cycle generates biosy
Externí odkaz:
https://doaj.org/article/519bfa2cafdc47bf912b8bcc970dfde2
Autor:
Victoria C. Yan, Yasaman Barekatain, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Kenisha Arthur, Dimitra K. Georgiou, Yongying Jiang, Yuting Sun, Joseph R. Marszalek, Steven W. Millward, Florian L. Muller
Publikováno v:
ACS Pharmacology & Translational Science. 6:245-252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d116915a4f3c5bc2a3ead8522b5bea3
https://doi.org/10.1021/acsptsci.2c00216
https://doi.org/10.1021/acsptsci.2c00216
Autor:
Victoria C. Yan, Cong-Dat Pham, Elliot S. Ballato, Kristine L. Yang, Kenisha Arthur, Sunada Khadka, Yasaman Barekatain, Prakriti Shrestha, Theresa Tran, Anton H. Poral, Mykia Washington, Sudhir Raghavan, Barbara Czako, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Steven W. Millward, Florian L. Muller
Publikováno v:
Journal of Medicinal Chemistry. 65:13813-13832
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c565c90ba8203219ba3e0da6dae7456
https://doi.org/10.1021/acs.jmedchem.2c01039
https://doi.org/10.1021/acs.jmedchem.2c01039
Autor:
Sunada Khadka, Yu-Hsi Lin, Jeffrey Ackroyd, Yi-An Chen, Yanghui Sheng, Wubin Qian, Sheng Guo, Yining Chen, Eliot Behr, Yasaman Barekatain, Md. Nasir Uddin, Kenisha Arthur, Victoria Yan, Wen-Hao Hsu, Edward Chang, Anton Poral, Theresa Tran, Surendra Chaurasia, Dimitra K. Georgiou, John M. Asara, Floris P. Barthel, Steve W. Millward, Ronald A. DePinho, Florian L. Muller
Tumor angiogenesis is a cancer hallmark, and its therapeutic inhibition has provided meaningful, albeit limited, clinical benefit. While anti-angiogenesis inhibitors deprive the tumor of oxygen and essential nutrients, cancer cells activate metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d46e48b0b718e73c869be6e50b0fc3a7
https://doi.org/10.1101/2023.05.07.539744
https://doi.org/10.1101/2023.05.07.539744
Autor:
Kenisha Arthur, John M. Asara, Anton H. Poral, Nikunj Satani, Yu Hsi Lin, Raghu Kalluri, Florian L. Muller, Sunada Khadka, Dimitra K. Georgiou, Theresa Tran, Jeffrey J. Ackroyd, Jason T. Huse, Victoria C. Yan, Yasaman Barekatain, Eliot Itzkow Behr, Lin Wang, Ana C. deCarvalho, Ko Chien Chen, Elliot S. Ballato, John de Groot, Roel G.W. Verhaak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous MTAP-deleted cell lines in culture show elevation of MTAP’s substrate metabolite, methylth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d9f6704f02c6b5337184c4f7765ff2
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
Autor:
Xiaobo Wang, Jeffrey J. Ackroyd, Yongying Jiang, Florian L. Muller, Yuting Sun, Federica Pisaneschi, Theresa Tran, Nikunj Satani, Cong-Dat Pham, Waldemar Priebe, Barbara Czako, Qi Wu, Paul G. Leonard, Ronald A. DePinho, Joseph R. Marszalek, John M. Asara, Pijus K. Mandal, Yasaman Barekatain, Susana Castro Pando, William G. Bornmann, Rafal Zielinski, Naima Hammoudi, Sunada Khadka, David Maxwell, Kenisha Arthur, Yu Hsi Lin, Quanyu Xu, Dimitra K. Georgiou, Victoria C. Yan, Zhijun Kang, Zhenghong Peng
Publikováno v:
Nature metabolism
Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. We have previously identified a subset of cancers harbouring homozygous deletion of the glycolytic enzyme enolase (ENO1) that have exceptional sensitivity to inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ad9fc9f1e815ba077a140b6ba621df
https://doi.org/10.1038/s42255-020-00313-3
https://doi.org/10.1038/s42255-020-00313-3
Autor:
Marissa N. Trujillo, Kenisha Arthur, John M. Asara, Cong-Dat Pham, Eliot Itzkow Behr, Sunada Khadka, Yu-Hsi Lin, Mykia Washington, Kaitlyn Crowley, Rafal Zielinski, Pornpa Suriyamongkol, Jeffrey J. Ackroyd, Yasaman Barekatain, Florian L. Muller, James J. Galligan, Dimitra K. Georgiou
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-17 (2021)
Cancer & Metabolism
Cancer & Metabolism
Background Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating cancer cells. In tumors, the tricarboxylic acid (TCA) cycle generates biosynthetic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17de4a0eabbecac955baa85e6a0dd7b9
https://doi.org/10.1186/s40170-021-00259-4
https://doi.org/10.1186/s40170-021-00259-4
Autor:
Sunada Khadka, Yu-Hsi Lin, Jeffery Ackroyd, Kenisha Arthur, Yasaman Barekatain, Anton Poral, Theresa Tran, Eliot Behr, Yining Chen, Dimitra Georgiou, Ronald Depinho, Florian Muller
Publikováno v:
Cancer Research. 82:3208-3208
Angiogenesis inhibition has become a mainstay of oncology despite having fallen short of its early promise. As originally envisioned, angiogenesis inhibition would cut off the blood supply, deprive tumor cells of key nutrients, leading to their demis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9235df45d6ee71d190249e3e54d2ca46
https://doi.org/10.1158/1538-7445.am2022-3208
https://doi.org/10.1158/1538-7445.am2022-3208
Autor:
Victoria C. Yan, Cong-Dat Pham, Matthew J. Yan, Alexander J. Yan, Sunada Khadka, Kenisha Arthur, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Laura E. Roon, Lane R. Bushman, Peter L. Anderson, Chun Li, Florian L. Muller
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 3
article-version (status) pre
article-version (number) 3
Despite being FDA-approved for COVID-19, the clinical efficacy of remdesivir (Veklury®) remains contentious. We previously pointed out pharmacokinetic, pharmacodynamic and toxicology reasons for why its parent nucleoside GS-441524, is better suited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322955a6640212fea42f02d037064495
https://doi.org/10.1101/2021.02.04.429674
https://doi.org/10.1101/2021.02.04.429674