Supplementary Figures 1-4 from Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma

Autor: Daniel V. Catenacci, Adam J. Bass, Jeeyun Lee, Viktor Adalsteinsson, Yu Imamura, Jon Davison, Denisse Rotem, Greg Gydush, Sarah Reed, Justin Rhoades, Samuel S. Freeman, Gavin Ha, Andres Gelrud, Uzma Siddiqui, Kyle Hogarth, Paul Chang, Kiran Turaga, Kevin Roggin, Mitchell C. Posner, Yuan Ji, Haley A. Coleman, Bruce M. Wollison, Matthew D. Ducar, Aaron R. Thorner, Andrew Dunford, David J. Oh, Agoston T. Agoston, Rick Lanman, Hideo Baba, Masayuki Watanabe, Lea O'Keefe, Katie S. Nason, Byung-Hoon Min, Min-Gew Choi, Kyoung-Mee Kim, Rebecca J. Nagy, John Hart, Shu-Yuan Xiao, Namrata Setia, Christopher Weber, Carrie Fitzpatrick, Rajani Kanteti, Melissa Maranto, Samantha Lomnicki, Emily O'Day, Kenisha Allen, Manish R. Sharma, Blase Polite, Hedy Kindler, Heewon Kwak, Lindsay Alpert, Mirazul Islam, Steven Maron, Yang Liu, Sarah Derks, Matthew D. Stachler, Eirini Pectasides

Supplementary Fig. 1: Mutation rate and ploidy for each individual patient's primary and metastatic sample (cohort 1);Supplementary Fig. 2: Validation of genomic heterogeneity within primary tumor and between primary tumor and lymph node (LN) metasta

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https://doi.org/10.1158/2159-8290.22534244.v1

Supplementary Figure Legends from Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma

Autor: Daniel V. Catenacci, Adam J. Bass, Jeeyun Lee, Viktor Adalsteinsson, Yu Imamura, Jon Davison, Denisse Rotem, Greg Gydush, Sarah Reed, Justin Rhoades, Samuel S. Freeman, Gavin Ha, Andres Gelrud, Uzma Siddiqui, Kyle Hogarth, Paul Chang, Kiran Turaga, Kevin Roggin, Mitchell C. Posner, Yuan Ji, Haley A. Coleman, Bruce M. Wollison, Matthew D. Ducar, Aaron R. Thorner, Andrew Dunford, David J. Oh, Agoston T. Agoston, Rick Lanman, Hideo Baba, Masayuki Watanabe, Lea O'Keefe, Katie S. Nason, Byung-Hoon Min, Min-Gew Choi, Kyoung-Mee Kim, Rebecca J. Nagy, John Hart, Shu-Yuan Xiao, Namrata Setia, Christopher Weber, Carrie Fitzpatrick, Rajani Kanteti, Melissa Maranto, Samantha Lomnicki, Emily O'Day, Kenisha Allen, Manish R. Sharma, Blase Polite, Hedy Kindler, Heewon Kwak, Lindsay Alpert, Mirazul Islam, Steven Maron, Yang Liu, Sarah Derks, Matthew D. Stachler, Eirini Pectasides

Supplementary Figure Legends

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https://doi.org/10.1158/2159-8290.22534247

Supplementary Tables 1-8 from Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma

Autor: Daniel V. Catenacci, Adam J. Bass, Jeeyun Lee, Viktor Adalsteinsson, Yu Imamura, Jon Davison, Denisse Rotem, Greg Gydush, Sarah Reed, Justin Rhoades, Samuel S. Freeman, Gavin Ha, Andres Gelrud, Uzma Siddiqui, Kyle Hogarth, Paul Chang, Kiran Turaga, Kevin Roggin, Mitchell C. Posner, Yuan Ji, Haley A. Coleman, Bruce M. Wollison, Matthew D. Ducar, Aaron R. Thorner, Andrew Dunford, David J. Oh, Agoston T. Agoston, Rick Lanman, Hideo Baba, Masayuki Watanabe, Lea O'Keefe, Katie S. Nason, Byung-Hoon Min, Min-Gew Choi, Kyoung-Mee Kim, Rebecca J. Nagy, John Hart, Shu-Yuan Xiao, Namrata Setia, Christopher Weber, Carrie Fitzpatrick, Rajani Kanteti, Melissa Maranto, Samantha Lomnicki, Emily O'Day, Kenisha Allen, Manish R. Sharma, Blase Polite, Hedy Kindler, Heewon Kwak, Lindsay Alpert, Mirazul Islam, Steven Maron, Yang Liu, Sarah Derks, Matthew D. Stachler, Eirini Pectasides

Supplementary Table 1. Tumor and sequencing information for Cohort 1, paired primary and metastatic gastric adenocarcinoma samples; Supplementary Table 2. 243-gene targeted panel used for sequencing of Cohort 2 samples; Supplementary Table 3: Wild ty

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https://doi.org/10.1158/2159-8290.22534238.v1

Clinical Activity of Olaparib in Urothelial Bladder Cancer With DNA Damage Response Gene Mutations

Autor: Kenisha Allen, Sabah Kadri, Randy F. Sweis, Walter M. Stadler, Dawn Conway, Carolyn Marinier, Lauren L. Ritterhouse, Sean P. Pitroda, Brian L. Heiss, Jane E. Churpek, Jeremy P. Segal, Norm D. Smith

Publikováno v: JCO Precision Oncology. :1-7

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https://doi.org/10.1200/po.18.00264

Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma

Autor: Haley A. Coleman, Gavin Ha, Lindsay Alpert, David J. Oh, Kevin K. Roggin, Jon M. Davison, Rick Lanman, Yang Liu, Rebecca J. Nagy, Emily O'Day, Jeeyun Lee, Shu-Yuan Xiao, Paul J. Chang, Min-Gew Choi, Viktor A. Adalsteinsson, Kyle Hogarth, Blase N. Polite, Hedy L. Kindler, Yuan Ji, Yu Imamura, Carrie Fitzpatrick, Steven Brad Maron, Katie S. Nason, Sarah Derks, Agoston T. Agoston, Justin Rhoades, Samantha Lomnicki, Namrata Setia, Kyoung-Mee Kim, Matthew D. Stachler, Hideo Baba, Daniel V.T. Catenacci, Melissa Maranto, John Hart, Lea O'Keefe, Samuel S. Freeman, Kiran K. Turaga, Andres Gelrud, Bruce M. Wollison, Masayuki Watanabe, Greg Gydush, Matthew D. Ducar, Kenisha Allen, Adam J. Bass, Manish R. Sharma, Denisse Rotem, Sarah C. Reed, Aaron R. Thorner, Uzma D. Siddiqui, Rajani Kanteti, Byung-Hoon Min, Mirazul Islam, Eirini Pectasides, Andrew Dunford, Christopher R. Weber, Heewon A. Kwak, Mitchell C. Posner

Publikováno v: Cancer discovery, vol 8, iss 1
Cancer discovery, 8(1), 37-48. American Association for Cancer Research Inc.
Pectasides, E, Stachler, M D, Derks, S, Liu, Y, Maron, S, Islam, M, Alpert, L, Kwak, H, Kindler, H, Polite, B, Sharma, M R, Allen, K, O’Day, E, Lomnicki, S, Maranto, M, Kanteti, R, Fitzpatrick, C, Weber, C, Setia, N, Xiao, S-Y, Hart, J, Nagy, R J, Kim, K-M, Choi, M-G, Min, B-H, Nason, K S, O’Keefe, L, Watanabe, M, Baba, H, Lanman, R, Agoston, A T, Oh, D J, Dunford, A, Thorner, A R, Ducar, M D, Wollison, B M, Coleman, H A, Ji, Y, Posner, M C, Roggin, K, Turaga, K, Chang, P, Hogarth, K, Siddiqui, U D, Gelrud, A, Ha, G, Freeman, S S, Rhoades, J, Reed, S, Gydush, G, Rotem, D, Davison, J, Imamura, Y, Adalsteinsson, V, Lee, J, Bass, A J & Catenacci, D V 2018, ' Genomic heterogeneity as a barrier to precision medicine in gastroesophageal adenocarcinoma ', Cancer discovery, vol. 8, no. 1, pp. 37-48 . https://doi.org/10.1158/2159-8290.CD-17-0395

Gastroesophageal adenocarcinoma (GEA) is a lethal disease where targeted therapies, even when guided by genomic biomarkers, have had limited efficacy. A potential reason for the failure of such therapies is that genomic profiling results could common

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https://escholarship.org/uc/item/8205x8v8